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- W1833062828 abstract "Higher organisms can regulate gene expression through changes in epigenetic marks present on thegenome. However, how this regulation takes place in organisms with highly repetitive/complexgenomes is not well understood.The acquisition of de novo DNA methylation in plants is mediated by siRNAs through the RNAdirectedDNA methylation (RdDM) pathway. The targeted deposition of DNA methylation bythis pathway allows for the transcriptional silencing of transposable elements and repeat sequenceswithin the genome, as well as regulating gene expression. In addition, it has been hypothesizedthat mobile siRNAs may be involved in the epigenetic communication between different seed components.Thus the mobility of non-coding RNAs from extra-embryonic tissues could contribute toepigenetic modifications that could be transmitted to the offspring.The aim of my thesis is to characterise the mechanisms involved in epigenetic gene silencing inmaize through the use of a novel transgenic reporter. My work has identified components of theRdDM pathway to be involved in maintenance of gene silencing and show that imprinting andparamutation could be recapitulated using synthetic transgenes. In addition, I developed a novelgrafting technique to demonstrate that epigenetic gene silencing could be efficiently transmittedbetween different seed components.Collectively, this work provides an insight into the complex mechanisms that regulate gene expressionin the highly repetitive/complex genome of maize." @default.
- W1833062828 created "2016-06-24" @default.
- W1833062828 creator A5007936617 @default.
- W1833062828 date "2013-05-01" @default.
- W1833062828 modified "2023-09-27" @default.
- W1833062828 title "Mechanisms underlying epigenetic gene silencing in maize" @default.
- W1833062828 hasPublicationYear "2013" @default.
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