FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1833135536> ?p ?o ?g. }

• W1833135536 endingPage "459" @default.
• W1833135536 startingPage "448" @default.
• W1833135536 abstract "CRISPR/Cas9 protein fused to transactivation domains can be used to control gene expression in human cells. In this study, we demonstrate that a dCas9 fusion with repeats of VP16 activator domains can efficiently activate human genes involved in pluripotency in various cell types. This activator in combination with guide RNAs targeted to the OCT4 promoter can be used to completely replace transgenic OCT4 in human cell reprogramming. Furthermore, we generated a chemically controllable dCas9 activator version by fusion with the dihydrofolate reductase (DHFR) destabilization domain. Finally, we show that the destabilized dCas9 activator can be used to control human pluripotent stem cell differentiation into endodermal lineages." @default.
• W1833135536 created "2016-06-24" @default.
• W1833135536 creator A5002698665 @default.
• W1833135536 creator A5034283186 @default.
• W1833135536 creator A5039143483 @default.
• W1833135536 creator A5054736043 @default.
• W1833135536 creator A5065863111 @default.
• W1833135536 creator A5081210039 @default.
• W1833135536 date "2015-09-01" @default.
• W1833135536 modified "2023-10-12" @default.
• W1833135536 title "Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation" @default.
• W1833135536 cites W1973260880 @default.
• W1833135536 cites W1976404496 @default.
• W1833135536 cites W1982846895 @default.
• W1833135536 cites W1995650558 @default.
• W1833135536 cites W2019903599 @default.
• W1833135536 cites W2026520402 @default.
• W1833135536 cites W2032141669 @default.
• W1833135536 cites W2032472678 @default.
• W1833135536 cites W2035121417 @default.
• W1833135536 cites W2045435533 @default.
• W1833135536 cites W2058527659 @default.
• W1833135536 cites W2061650108 @default.
• W1833135536 cites W2064815984 @default.
• W1833135536 cites W2066783444 @default.
• W1833135536 cites W2070134501 @default.
• W1833135536 cites W2070172761 @default.
• W1833135536 cites W2070614858 @default.
• W1833135536 cites W2072239613 @default.
• W1833135536 cites W2075230442 @default.
• W1833135536 cites W2089589904 @default.
• W1833135536 cites W2101749257 @default.
• W1833135536 cites W2103081715 @default.
• W1833135536 cites W2105582260 @default.
• W1833135536 cites W2120932131 @default.
• W1833135536 cites W2126259097 @default.
• W1833135536 cites W2127158541 @default.
• W1833135536 cites W2127862779 @default.
• W1833135536 cites W2129194497 @default.
• W1833135536 cites W2149142532 @default.
• W1833135536 cites W2152102410 @default.
• W1833135536 cites W2152505144 @default.
• W1833135536 cites W2155968127 @default.
• W1833135536 cites W2160051211 @default.
• W1833135536 cites W2163173465 @default.
• W1833135536 cites W2169373177 @default.
• W1833135536 cites W4206892629 @default.
• W1833135536 cites W4292230674 @default.
• W1833135536 doi "https://doi.org/10.1016/j.stemcr.2015.08.001" @default.
• W1833135536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4618656" @default.
• W1833135536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26352799" @default.
• W1833135536 hasPublicationYear "2015" @default.
• W1833135536 type Work @default.
• W1833135536 sameAs 1833135536 @default.
• W1833135536 citedByCount "143" @default.
• W1833135536 countsByYear W18331355362015 @default.
• W1833135536 countsByYear W18331355362016 @default.
• W1833135536 countsByYear W18331355362017 @default.
• W1833135536 countsByYear W18331355362018 @default.
• W1833135536 countsByYear W18331355362019 @default.
• W1833135536 countsByYear W18331355362020 @default.
• W1833135536 countsByYear W18331355362021 @default.
• W1833135536 countsByYear W18331355362022 @default.
• W1833135536 countsByYear W18331355362023 @default.
• W1833135536 crossrefType "journal-article" @default.
• W1833135536 hasAuthorship W1833135536A5002698665 @default.
• W1833135536 hasAuthorship W1833135536A5034283186 @default.
• W1833135536 hasAuthorship W1833135536A5039143483 @default.
• W1833135536 hasAuthorship W1833135536A5054736043 @default.
• W1833135536 hasAuthorship W1833135536A5065863111 @default.
• W1833135536 hasAuthorship W1833135536A5081210039 @default.
• W1833135536 hasBestOaLocation W18331355361 @default.
• W1833135536 hasConcept C104317684 @default.
• W1833135536 hasConcept C107459253 @default.
• W1833135536 hasConcept C1292079 @default.
• W1833135536 hasConcept C145103041 @default.
• W1833135536 hasConcept C148738053 @default.
• W1833135536 hasConcept C150194340 @default.
• W1833135536 hasConcept C165864922 @default.
• W1833135536 hasConcept C54355233 @default.
• W1833135536 hasConcept C77255625 @default.
• W1833135536 hasConcept C86803240 @default.
• W1833135536 hasConcept C88045685 @default.
• W1833135536 hasConcept C95444343 @default.
• W1833135536 hasConcept C98108389 @default.
• W1833135536 hasConceptScore W1833135536C104317684 @default.
• W1833135536 hasConceptScore W1833135536C107459253 @default.
• W1833135536 hasConceptScore W1833135536C1292079 @default.
• W1833135536 hasConceptScore W1833135536C145103041 @default.
• W1833135536 hasConceptScore W1833135536C148738053 @default.
• W1833135536 hasConceptScore W1833135536C150194340 @default.
• W1833135536 hasConceptScore W1833135536C165864922 @default.
• W1833135536 hasConceptScore W1833135536C54355233 @default.
• W1833135536 hasConceptScore W1833135536C77255625 @default.
• W1833135536 hasConceptScore W1833135536C86803240 @default.
• W1833135536 hasConceptScore W1833135536C88045685 @default.
• W1833135536 hasConceptScore W1833135536C95444343 @default.
• W1833135536 hasConceptScore W1833135536C98108389 @default.

• next