Matches in SemOpenAlex for { <https://semopenalex.org/work/W1833135903> ?p ?o ?g. }
- W1833135903 endingPage "734" @default.
- W1833135903 startingPage "723" @default.
- W1833135903 abstract "Type 1 diabetes mellitus (T1DM) is caused by the selective deletion of pancreatic β-cells in response to an assault mounted within the pancreas by infiltrating immune cells. However, this apparently clear and focussed annunciation conceals a stark reality in which the cellular and molecular events leading to β-cell loss remain poorly understood in humans. This reflects the difficulty of studying these processes in living individuals and the fact that, using pathological specimens, islet inflammation has been analysed in fewer than 200 recent-onset cases of T1DM worldwide, over the past century. Nevertheless, insights have been gained and the composition of the islet infiltrate is being disclosed. This is shown to be primarily lymphocytic in nature, with populations of both CD8+ and CD4+ T cells displaying an autoreactivity against specific islet antigenic peptides. The T cells are often accompanied by influent CD20+ B cells, although new data imply that the proportions of these individual cell types vary and that patients fall into at least two distinct categories having either a hyper-immune (CD20Hi) or a pauci-immune (CD20Lo) phenotype. The overall rate of β-cell decline appears to correlate with these two phenotypes such that hyper-immune patients lose β-cells more quickly and tend to develop disease at an earlier age than those with the pauci-immune profile. In this article, we review the evidence which underpins our current understanding of the aetiology of T1DM and highlight both the established features as well as areas of on-going ambiguity and debate. © 2014 IUBMB Life, 66(11):723–734, 2014" @default.
- W1833135903 created "2016-06-24" @default.
- W1833135903 creator A5018311311 @default.
- W1833135903 creator A5019744167 @default.
- W1833135903 creator A5035490035 @default.
- W1833135903 creator A5058034008 @default.
- W1833135903 date "2014-11-01" @default.
- W1833135903 modified "2023-09-23" @default.
- W1833135903 title "Islet inflammation in human type 1 diabetes mellitus" @default.
- W1833135903 cites W1504366326 @default.
- W1833135903 cites W1608842679 @default.
- W1833135903 cites W1839191151 @default.
- W1833135903 cites W1943720579 @default.
- W1833135903 cites W1970745637 @default.
- W1833135903 cites W1981231681 @default.
- W1833135903 cites W1983206326 @default.
- W1833135903 cites W1983380435 @default.
- W1833135903 cites W1985490387 @default.
- W1833135903 cites W1987101799 @default.
- W1833135903 cites W1990978402 @default.
- W1833135903 cites W1993142864 @default.
- W1833135903 cites W1994236426 @default.
- W1833135903 cites W1998861085 @default.
- W1833135903 cites W2002365657 @default.
- W1833135903 cites W2005189185 @default.
- W1833135903 cites W2010646329 @default.
- W1833135903 cites W2013100047 @default.
- W1833135903 cites W2016191763 @default.
- W1833135903 cites W2017971549 @default.
- W1833135903 cites W2018866981 @default.
- W1833135903 cites W2019605333 @default.
- W1833135903 cites W2020629155 @default.
- W1833135903 cites W2028170333 @default.
- W1833135903 cites W2029614362 @default.
- W1833135903 cites W2037884311 @default.
- W1833135903 cites W2043204562 @default.
- W1833135903 cites W2044900330 @default.
- W1833135903 cites W2047278218 @default.
- W1833135903 cites W2050995545 @default.
- W1833135903 cites W2053577320 @default.
- W1833135903 cites W2054821923 @default.
- W1833135903 cites W2061574308 @default.
- W1833135903 cites W2063442682 @default.
- W1833135903 cites W2064034227 @default.
- W1833135903 cites W2064431167 @default.
- W1833135903 cites W2065020763 @default.
- W1833135903 cites W2068387198 @default.
- W1833135903 cites W2070915004 @default.
- W1833135903 cites W2078504572 @default.
- W1833135903 cites W2085275112 @default.
- W1833135903 cites W2085721222 @default.
- W1833135903 cites W2085773540 @default.
- W1833135903 cites W2087644204 @default.
- W1833135903 cites W2087922175 @default.
- W1833135903 cites W2088113216 @default.
- W1833135903 cites W2088945279 @default.
- W1833135903 cites W2089072284 @default.
- W1833135903 cites W2091770132 @default.
- W1833135903 cites W2092174567 @default.
- W1833135903 cites W2097729476 @default.
- W1833135903 cites W2099862791 @default.
- W1833135903 cites W2103302952 @default.
- W1833135903 cites W2112328520 @default.
- W1833135903 cites W2113217592 @default.
- W1833135903 cites W2117146326 @default.
- W1833135903 cites W2117657337 @default.
- W1833135903 cites W2119249252 @default.
- W1833135903 cites W2124025841 @default.
- W1833135903 cites W2125415795 @default.
- W1833135903 cites W2127354797 @default.
- W1833135903 cites W2140655516 @default.
- W1833135903 cites W2141263550 @default.
- W1833135903 cites W2149895222 @default.
- W1833135903 cites W2158086063 @default.
- W1833135903 cites W2161993072 @default.
- W1833135903 cites W2164707000 @default.
- W1833135903 cites W2165057708 @default.
- W1833135903 cites W2169845440 @default.
- W1833135903 cites W2171289415 @default.
- W1833135903 cites W2326904657 @default.
- W1833135903 cites W2332910275 @default.
- W1833135903 cites W3039233428 @default.
- W1833135903 cites W342420634 @default.
- W1833135903 cites W4211187729 @default.
- W1833135903 doi "https://doi.org/10.1002/iub.1330" @default.
- W1833135903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25504835" @default.
- W1833135903 hasPublicationYear "2014" @default.
- W1833135903 type Work @default.
- W1833135903 sameAs 1833135903 @default.
- W1833135903 citedByCount "60" @default.
- W1833135903 countsByYear W18331359032015 @default.
- W1833135903 countsByYear W18331359032016 @default.
- W1833135903 countsByYear W18331359032017 @default.
- W1833135903 countsByYear W18331359032018 @default.
- W1833135903 countsByYear W18331359032019 @default.
- W1833135903 countsByYear W18331359032020 @default.
- W1833135903 countsByYear W18331359032021 @default.
- W1833135903 countsByYear W18331359032022 @default.