Matches in SemOpenAlex for { <https://semopenalex.org/work/W1833306283> ?p ?o ?g. }
- W1833306283 endingPage "50" @default.
- W1833306283 startingPage "36" @default.
- W1833306283 abstract "There is an emerging interest in the use of cellular models to study psychiatric disorders. We have systematically reviewed the application of cellular models to understand the biological basis of bipolar disorder (BD).Published scientific literature in MEDLINE, PsychINFO and SCOPUS databases were identified with the following search strategy: [(Lymphoblastoid OR Lymphoblast OR Fibroblast OR Pluripotent OR Olfactory epithelium OR Olfactory mucosa) AND (Bipolar disorder OR Lithium OR Valproate OR Mania)]. Studies were included if they had used cell cultures derived from BD patients.There were 65 articles on lymphoblastoid cell lines, 14 articles on fibroblasts, 4 articles on olfactory neuronal epithelium (ONE) and 2 articles on neurons reprogrammed from induced pluripotent stem cell lines (IPSC). Several parameters have been studied, and the most replicated findings are abnormalities in calcium signaling, endoplasmic reticulum (ER) stress response, mitochondrial oxidative pathway, membrane ion channels, circadian system and apoptosis related genes. These, although present in basal state, seem to be accentuated in the presence of cellular stressors (e.g. oxidative stress--rotenone; ER stress--thapsigargin), and are often reversed with in-vitro lithium.Cellular modeling has proven useful in BD, and potential pathways, especially in cellular resilience related mechanisms have been identified. These findings show consistency with other study designs (genome-wide association, brain-imaging, and post-mortem brain expression). ONE cells and IPSC reprogrammed neurons represent the next generation of cell models in BD. Future studies should focus on family-based study designs and combine cell models with deep sequencing and genetic manipulations." @default.
- W1833306283 created "2016-06-24" @default.
- W1833306283 creator A5018927276 @default.
- W1833306283 creator A5025869866 @default.
- W1833306283 creator A5026751784 @default.
- W1833306283 creator A5033241965 @default.
- W1833306283 creator A5042407848 @default.
- W1833306283 creator A5053853143 @default.
- W1833306283 creator A5061703839 @default.
- W1833306283 creator A5069680537 @default.
- W1833306283 creator A5077802428 @default.
- W1833306283 creator A5080602595 @default.
- W1833306283 date "2015-09-01" @default.
- W1833306283 modified "2023-09-26" @default.
- W1833306283 title "Cellular models to study bipolar disorder: A systematic review" @default.
- W1833306283 cites W1506541734 @default.
- W1833306283 cites W1557005410 @default.
- W1833306283 cites W1568100872 @default.
- W1833306283 cites W1853587966 @default.
- W1833306283 cites W1928940538 @default.
- W1833306283 cites W1970479888 @default.
- W1833306283 cites W1971441925 @default.
- W1833306283 cites W1971816469 @default.
- W1833306283 cites W1973904687 @default.
- W1833306283 cites W1975837197 @default.
- W1833306283 cites W1976401824 @default.
- W1833306283 cites W1976462942 @default.
- W1833306283 cites W1979378430 @default.
- W1833306283 cites W1979603195 @default.
- W1833306283 cites W1979873290 @default.
- W1833306283 cites W1980790208 @default.
- W1833306283 cites W1984120803 @default.
- W1833306283 cites W1984802122 @default.
- W1833306283 cites W1985277262 @default.
- W1833306283 cites W1987620105 @default.
- W1833306283 cites W1988376707 @default.
- W1833306283 cites W1991642476 @default.
- W1833306283 cites W1993588417 @default.
- W1833306283 cites W1994740383 @default.
- W1833306283 cites W1995653774 @default.
- W1833306283 cites W1999491804 @default.
- W1833306283 cites W2002766976 @default.
- W1833306283 cites W2003253047 @default.
- W1833306283 cites W2004633023 @default.
- W1833306283 cites W2004647785 @default.
- W1833306283 cites W2004822431 @default.
- W1833306283 cites W2005710138 @default.
- W1833306283 cites W2005760116 @default.
- W1833306283 cites W2007743667 @default.
- W1833306283 cites W2008468014 @default.
- W1833306283 cites W2017446917 @default.
- W1833306283 cites W2017878901 @default.
- W1833306283 cites W2021893579 @default.
- W1833306283 cites W2021927593 @default.
- W1833306283 cites W2027042547 @default.
- W1833306283 cites W2028541149 @default.
- W1833306283 cites W2029429927 @default.
- W1833306283 cites W2031892268 @default.
- W1833306283 cites W2032443261 @default.
- W1833306283 cites W2035914960 @default.
- W1833306283 cites W2036192755 @default.
- W1833306283 cites W2038664453 @default.
- W1833306283 cites W2041450670 @default.
- W1833306283 cites W2042102243 @default.
- W1833306283 cites W2046469450 @default.
- W1833306283 cites W2046645663 @default.
- W1833306283 cites W2047086907 @default.
- W1833306283 cites W2048922260 @default.
- W1833306283 cites W2050097253 @default.
- W1833306283 cites W2050683333 @default.
- W1833306283 cites W2052209587 @default.
- W1833306283 cites W2052268272 @default.
- W1833306283 cites W2052813369 @default.
- W1833306283 cites W2053534083 @default.
- W1833306283 cites W2054771042 @default.
- W1833306283 cites W2061843844 @default.
- W1833306283 cites W2063368103 @default.
- W1833306283 cites W2067891510 @default.
- W1833306283 cites W2068463224 @default.
- W1833306283 cites W2069059718 @default.
- W1833306283 cites W2070542958 @default.
- W1833306283 cites W2074237270 @default.
- W1833306283 cites W2075880317 @default.
- W1833306283 cites W2077476706 @default.
- W1833306283 cites W2078417534 @default.
- W1833306283 cites W2079583552 @default.
- W1833306283 cites W2081236115 @default.
- W1833306283 cites W2081678549 @default.
- W1833306283 cites W2083619940 @default.
- W1833306283 cites W2086477428 @default.
- W1833306283 cites W2087786585 @default.
- W1833306283 cites W2089687537 @default.
- W1833306283 cites W2089993812 @default.
- W1833306283 cites W2095498339 @default.
- W1833306283 cites W2096261947 @default.
- W1833306283 cites W2096363941 @default.
- W1833306283 cites W2096973446 @default.
- W1833306283 cites W2098164623 @default.