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• W1833315858 abstract "Mortality among 5,413 white males who were employed for at least two years at a plutonium weapons facility was investigated to measure risks from exposures to low levels of plutonium and external radiation. When compared with US death rates, fewer deaths than expected were found for all causes of death, all cancers, and lung cancer. No bone cancer was observed. An excess of brain tumors was found for the cohort in general. Elevated rate ratios for all causes of death and all lymphopoietic neoplasms were found when employees with plutonium body burdens ≥2 nCi were compared with those with body burdens <2 nCi, while accounting for age, calendar period, and induction time. Increased rate ratios were also found for esophageal, stomach, colon, and prostate cancers, and for lymphosarcomas and reticulum cell sarcomas. No elevated rate ratios were noted for bone and liver cancers. When employees with cumulative exposures ≥1 rem were compared with those with exposures <1 rem, elevated rate ratios were found for myelold leukemia, lymphosarcoma and reticulum cell sarcoma, liver neoplasms, and unspecified brain tumors. No overall dose-response relationships were found for plutonium or external radiation exposures. Standardized rate ratios increased, however, as plutonium body burden levels increased for all causes, all cancers, and digestive cancers at live years induction time. Standardized rate ratios also increased as external radiation exposure categories in creased for all lymphopoletic cancers and unspecified brain tumors for a two-year induction period. With the exception of analyses of combined categories of death, and perhaps of lung cancer, confidence limits were wide, indicating limited precision. Nevertheless, these findings suggest that increased risks for several types of cancers cannot be ruled out at this time for individuals with plutonium body burdens of ≥2 nCi. Plutonium-burdened individuals should continue to be studied in future years." @default.
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• W1833315858 date "1987-02-01" @default.
• W1833315858 modified "2023-10-11" @default.
• W1833315858 title "MORTALITY AMONG PLUTONIUM ANI) OTHER RADIATION WORKERS AT A PLUTONIUM WEAPONS FACILITY" @default.
• W1833315858 doi "https://doi.org/10.1093/oxfordjournals.aje.a114523" @default.
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