FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1833382012> ?p ?o ?g. }

• W1833382012 endingPage "1209" @default.
• W1833382012 startingPage "1205" @default.
• W1833382012 abstract "Aerosol delivery via a mechanical ventilator remains unregulated with no standards for drug delivery to intubated patients. Bench models predicting drug delivery have not been validated in vivo. For modern ventilator designs, we chose to identify, on the bench, the most important variables affecting aerosol delivery and to correlate in vitro predictions of aerosol delivery with in vivo end points independent of patient response. Test aerosols of albuterol and antibiotics were compared. Bench measurements of inhaled mass (percentage of nebulizer charge, mean +/- SEM) ranged from 5.7 +/- 0.5% to 37.4 +/- 1.6%, with breath-actuated nebulization and humidity identified as the most important factors determining aerosol delivery. In patients, sputum levels of deposited antibiotics varied from 1.10 to 19.6 microg/ml/mg. Variation in sputum levels correlated with predictions from the in vitro model. Aerosol delivery in ventilated patients can be efficient and reproducible only if defined ventilator parameters are tightly controlled. Key parameters can be determined via in vitro bench testing defining delivery standards for clinical trials of drugs with narrow therapeutic/toxicity ratios." @default.
• W1833382012 created "2016-06-24" @default.
• W1833382012 creator A5028396045 @default.
• W1833382012 creator A5034160929 @default.
• W1833382012 creator A5050953040 @default.
• W1833382012 creator A5071027605 @default.
• W1833382012 creator A5074107781 @default.
• W1833382012 date "2003-11-15" @default.
• W1833382012 modified "2023-10-18" @default.
• W1833382012 title "Aerosol Delivery and Modern Mechanical Ventilation" @default.
• W1833382012 cites W1965865248 @default.
• W1833382012 cites W1974845747 @default.
• W1833382012 cites W2000812824 @default.
• W1833382012 cites W2023305713 @default.
• W1833382012 cites W2033241761 @default.
• W1833382012 cites W2053518757 @default.
• W1833382012 cites W2062811430 @default.
• W1833382012 cites W2084216737 @default.
• W1833382012 cites W2114817353 @default.
• W1833382012 cites W2122744323 @default.
• W1833382012 cites W2124365177 @default.
• W1833382012 cites W2125937299 @default.
• W1833382012 doi "https://doi.org/10.1164/rccm.200210-1167oc" @default.
• W1833382012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12893644" @default.
• W1833382012 hasPublicationYear "2003" @default.
• W1833382012 type Work @default.
• W1833382012 sameAs 1833382012 @default.
• W1833382012 citedByCount "203" @default.
• W1833382012 countsByYear W18333820122012 @default.
• W1833382012 countsByYear W18333820122013 @default.
• W1833382012 countsByYear W18333820122014 @default.
• W1833382012 countsByYear W18333820122015 @default.
• W1833382012 countsByYear W18333820122016 @default.
• W1833382012 countsByYear W18333820122017 @default.
• W1833382012 countsByYear W18333820122018 @default.
• W1833382012 countsByYear W18333820122019 @default.
• W1833382012 countsByYear W18333820122020 @default.
• W1833382012 countsByYear W18333820122021 @default.
• W1833382012 countsByYear W18333820122022 @default.
• W1833382012 countsByYear W18333820122023 @default.
• W1833382012 crossrefType "journal-article" @default.
• W1833382012 hasAuthorship W1833382012A5028396045 @default.
• W1833382012 hasAuthorship W1833382012A5034160929 @default.
• W1833382012 hasAuthorship W1833382012A5050953040 @default.
• W1833382012 hasAuthorship W1833382012A5071027605 @default.
• W1833382012 hasAuthorship W1833382012A5074107781 @default.
• W1833382012 hasConcept C136229726 @default.
• W1833382012 hasConcept C142724271 @default.
• W1833382012 hasConcept C150903083 @default.
• W1833382012 hasConcept C171250308 @default.
• W1833382012 hasConcept C178790620 @default.
• W1833382012 hasConcept C185592680 @default.
• W1833382012 hasConcept C192562407 @default.
• W1833382012 hasConcept C207001950 @default.
• W1833382012 hasConcept C2776301714 @default.
• W1833382012 hasConcept C2776954882 @default.
• W1833382012 hasConcept C2777080012 @default.
• W1833382012 hasConcept C2779345167 @default.
• W1833382012 hasConcept C2779820397 @default.
• W1833382012 hasConcept C2780352487 @default.
• W1833382012 hasConcept C2781069245 @default.
• W1833382012 hasConcept C42219234 @default.
• W1833382012 hasConcept C71924100 @default.
• W1833382012 hasConcept C86803240 @default.
• W1833382012 hasConcept C98274493 @default.
• W1833382012 hasConceptScore W1833382012C136229726 @default.
• W1833382012 hasConceptScore W1833382012C142724271 @default.
• W1833382012 hasConceptScore W1833382012C150903083 @default.
• W1833382012 hasConceptScore W1833382012C171250308 @default.
• W1833382012 hasConceptScore W1833382012C178790620 @default.
• W1833382012 hasConceptScore W1833382012C185592680 @default.
• W1833382012 hasConceptScore W1833382012C192562407 @default.
• W1833382012 hasConceptScore W1833382012C207001950 @default.
• W1833382012 hasConceptScore W1833382012C2776301714 @default.
• W1833382012 hasConceptScore W1833382012C2776954882 @default.
• W1833382012 hasConceptScore W1833382012C2777080012 @default.
• W1833382012 hasConceptScore W1833382012C2779345167 @default.
• W1833382012 hasConceptScore W1833382012C2779820397 @default.
• W1833382012 hasConceptScore W1833382012C2780352487 @default.
• W1833382012 hasConceptScore W1833382012C2781069245 @default.
• W1833382012 hasConceptScore W1833382012C42219234 @default.
• W1833382012 hasConceptScore W1833382012C71924100 @default.
• W1833382012 hasConceptScore W1833382012C86803240 @default.
• W1833382012 hasConceptScore W1833382012C98274493 @default.
• W1833382012 hasIssue "10" @default.
• W1833382012 hasLocation W18333820121 @default.
• W1833382012 hasLocation W18333820122 @default.
• W1833382012 hasOpenAccess W1833382012 @default.
• W1833382012 hasPrimaryLocation W18333820121 @default.
• W1833382012 hasRelatedWork W2051935483 @default.
• W1833382012 hasRelatedWork W2070287461 @default.
• W1833382012 hasRelatedWork W2076681025 @default.
• W1833382012 hasRelatedWork W2212780187 @default.
• W1833382012 hasRelatedWork W2348346546 @default.
• W1833382012 hasRelatedWork W2357083477 @default.
• W1833382012 hasRelatedWork W2369739181 @default.
• W1833382012 hasRelatedWork W2385034495 @default.
• W1833382012 hasRelatedWork W2393839202 @default.

• next