FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1833727215> ?p ?o ?g. }

• W1833727215 endingPage "5112" @default.
• W1833727215 startingPage "5107" @default.
• W1833727215 abstract "Lipopolysaccharide (LPS) is cleared from the blood mainly by the liver. The Kupffer cells are primarily responsible for this clearance; liver endothelial and parenchymal cells contribute to a lesser extent. Although several binding sites have been described, only CD14 is known to be involved in LPS signalling. Among the other LPS binding sites that have been identified are scavenger receptors. Scavenger receptor class A (SR-A) types I and II are expressed in the liver on endothelial cells and Kupffer cells, and a 95-kDa receptor, identified as macrosialin, is expressed on Kupffer cells. In this study, we examined the role of scavenger receptors in the binding of LPS by the liver in vivo and in vitro. Fucoidin, a scavenger receptor ligand, significantly reduced the clearance of 125I-LPS from the serum and decreased the liver uptake of 125I-LPS about 40%. Within the liver, the in vivo binding of 125I-LPS to Kupffer and liver endothelial cells was decreased 72 and 71%, respectively, while the binding of 125I-LPS to liver parenchymal cells increased 34% upon fucoidin preinjection. Poly(I) inhibited the binding of 125I-LPS to Kupffer and endothelial cells in vitro 73 and 78%, respectively, while poly(A) had no effect. LPS inhibited the binding of acetylated low-density lipoprotein (acLDL) to Kupffer and liver endothelial cells 40 and 55%, respectively, and the binding of oxidized LDL (oxLDL) to Kupffer and liver endothelial cells 65 and 61%, respectively. oxLDL and acLDL did not significantly inhibit the binding of LPS to these cells. We conclude that on both endothelial cells and Kupffer cells, LPS binds mainly to scavenger receptors, but SR-A and macrosialin contribute to a limited extent to the binding of LPS." @default.
• W1833727215 created "2016-06-24" @default.
• W1833727215 creator A5002460140 @default.
• W1833727215 creator A5024733637 @default.
• W1833727215 creator A5048863073 @default.
• W1833727215 creator A5068769731 @default.
• W1833727215 date "1998-11-01" @default.
• W1833727215 modified "2023-10-14" @default.
• W1833727215 title "New Scavenger Receptor-Like Receptors for the Binding of Lipopolysaccharide to Liver Endothelial and Kupffer Cells" @default.
• W1833727215 cites W119361745 @default.
• W1833727215 cites W122471107 @default.
• W1833727215 cites W135545259 @default.
• W1833727215 cites W1490154674 @default.
• W1833727215 cites W1519847653 @default.
• W1833727215 cites W1524139871 @default.
• W1833727215 cites W1554698754 @default.
• W1833727215 cites W1559686163 @default.
• W1833727215 cites W1574380753 @default.
• W1833727215 cites W1581935652 @default.
• W1833727215 cites W1582984670 @default.
• W1833727215 cites W1692972836 @default.
• W1833727215 cites W1766658148 @default.
• W1833727215 cites W1881367260 @default.
• W1833727215 cites W1966312417 @default.
• W1833727215 cites W1983102026 @default.
• W1833727215 cites W2002140846 @default.
• W1833727215 cites W2002482575 @default.
• W1833727215 cites W2004220277 @default.
• W1833727215 cites W2010701664 @default.
• W1833727215 cites W2021418970 @default.
• W1833727215 cites W2029157767 @default.
• W1833727215 cites W2032731208 @default.
• W1833727215 cites W2037599912 @default.
• W1833727215 cites W2038484123 @default.
• W1833727215 cites W2049401036 @default.
• W1833727215 cites W2067338751 @default.
• W1833727215 cites W2074662959 @default.
• W1833727215 cites W2077151758 @default.
• W1833727215 cites W2078922491 @default.
• W1833727215 cites W2085649019 @default.
• W1833727215 cites W2085952814 @default.
• W1833727215 cites W2091535618 @default.
• W1833727215 cites W2094858554 @default.
• W1833727215 cites W2107611361 @default.
• W1833727215 cites W2113828544 @default.
• W1833727215 cites W2118777827 @default.
• W1833727215 cites W2120626817 @default.
• W1833727215 cites W2123228131 @default.
• W1833727215 cites W2123987062 @default.
• W1833727215 cites W2139193480 @default.
• W1833727215 cites W2142683017 @default.
• W1833727215 cites W2162458714 @default.
• W1833727215 cites W2166648967 @default.
• W1833727215 cites W2168699998 @default.
• W1833727215 cites W2170495397 @default.
• W1833727215 cites W2410023228 @default.
• W1833727215 cites W2412907297 @default.
• W1833727215 cites W2439642902 @default.
• W1833727215 cites W2467404952 @default.
• W1833727215 cites W74607236 @default.
• W1833727215 doi "https://doi.org/10.1128/iai.66.11.5107-5112.1998" @default.
• W1833727215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/108636" @default.
• W1833727215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9784510" @default.
• W1833727215 hasPublicationYear "1998" @default.
• W1833727215 type Work @default.
• W1833727215 sameAs 1833727215 @default.
• W1833727215 citedByCount "57" @default.
• W1833727215 countsByYear W18337272152012 @default.
• W1833727215 countsByYear W18337272152013 @default.
• W1833727215 countsByYear W18337272152014 @default.
• W1833727215 countsByYear W18337272152015 @default.
• W1833727215 countsByYear W18337272152016 @default.
• W1833727215 countsByYear W18337272152017 @default.
• W1833727215 countsByYear W18337272152018 @default.
• W1833727215 countsByYear W18337272152020 @default.
• W1833727215 countsByYear W18337272152021 @default.
• W1833727215 countsByYear W18337272152022 @default.
• W1833727215 countsByYear W18337272152023 @default.
• W1833727215 crossrefType "journal-article" @default.
• W1833727215 hasAuthorship W1833727215A5002460140 @default.
• W1833727215 hasAuthorship W1833727215A5024733637 @default.
• W1833727215 hasAuthorship W1833727215A5048863073 @default.
• W1833727215 hasAuthorship W1833727215A5068769731 @default.
• W1833727215 hasBestOaLocation W18337272151 @default.
• W1833727215 hasConcept C123012128 @default.
• W1833727215 hasConcept C126322002 @default.
• W1833727215 hasConcept C134018914 @default.
• W1833727215 hasConcept C153911025 @default.
• W1833727215 hasConcept C170493617 @default.
• W1833727215 hasConcept C195521686 @default.
• W1833727215 hasConcept C202751555 @default.
• W1833727215 hasConcept C203014093 @default.
• W1833727215 hasConcept C2778163477 @default.
• W1833727215 hasConcept C2778754761 @default.
• W1833727215 hasConcept C2778904781 @default.
• W1833727215 hasConcept C2780072125 @default.
• W1833727215 hasConcept C2908801736 @default.
• W1833727215 hasConcept C41443022 @default.

• next