FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1833748982> ?p ?o ?g. }

• W1833748982 abstract "BACKGROUND: Stress fractures are one of the more severe overuse injuries and occur more frequently in women than men. Location and severity of stress fractures vary according to the sport and intensity of physical activity and most commonly involve the lower extremities. The treatment period may extend beyond 12 weeks based on the severity of the stress fracture and physical activity of the patient. Although data are sparse, there is an evolving interest in using systemic medical interventions to potentially improve or accelerate stress fracture repair. Intermittent administration of human recombinant parathyroid hormone (PTH) (1-34) (Teriparatide) is a FDA-approved anabolic treatment used to treat osteoporosis in men and women and reduce fracture risk in postmenopausal women. Although there may be potential benefits of systemic v teriparatide therapy to hasten the healing of fractures, there only a few randomized, controlled studies at present. OBJECTIVES: To determine in this randomized, placebo-controlled study whether teriparatide can increase the anabolic window in premenopausal women with lower extremity stress fractures and can hasten the healing process, as assessed by Magnetic Resonance Imaging (MRI). Specifically, we will evaluate: 1) Whether bone formation markers increases more rapidly than resorption markers in response to daily teriparatide (20 μg) at 4 and 8 weeks and of the anabolic window, using the area under the curve between percent changes in biomarkers of formation over resorption over time, and 2) whether there is acceleration of the stress fracture healing, as assessed by MRI images. METHODS: Among 101 women screened for this study, 13 women were enrolled and randomized to receive teriparatide (20 μg) (n=6) or placebo (n=7) for 8 weeks in a double-blinded trial. Lab evaluations were completed at each visit (i.e. baseline, 4 weeks and 8 weeks) for 25-hydroxyvitamin D (25(OH)D), serum and urinary calcium, PTH, thyroid-stimulating hormone (TSH), and alkaline phosphate as well as BTM; amino-terminal propeptide of type I collagen (P1NP) and osteocalcin (OC) for bone formation and serum type I collagen c-telopeptides (CTX) and urinary type I collagen-telopeptides for bone resorption. To assess fracture healing, MRI images were reviewed by a radiologist specializing in MRI imaging and who was blinded to the treatment interventions. MRI images were obtained at baseline and 8 weeks and graded on a 0 to 4 scale. Grade 4" @default.
• W1833748982 created "2016-06-24" @default.
• W1833748982 creator A5054587371 @default.
• W1833748982 date "2013-01-01" @default.
• W1833748982 modified "2023-09-26" @default.
• W1833748982 title "Effects of recombinant human parathyroid hormone on the anabolic window and acceleration of lower extremity stress fracture healing" @default.
• W1833748982 cites W1525974497 @default.
• W1833748982 cites W182125183 @default.
• W1833748982 cites W1965296596 @default.
• W1833748982 cites W1966249606 @default.
• W1833748982 cites W1966994557 @default.
• W1833748982 cites W1969068959 @default.
• W1833748982 cites W1972397746 @default.
• W1833748982 cites W1972933388 @default.
• W1833748982 cites W1976875310 @default.
• W1833748982 cites W1985623559 @default.
• W1833748982 cites W1993088612 @default.
• W1833748982 cites W1994169116 @default.
• W1833748982 cites W1996656034 @default.
• W1833748982 cites W2013079995 @default.
• W1833748982 cites W2015637821 @default.
• W1833748982 cites W2021323052 @default.
• W1833748982 cites W2021623450 @default.
• W1833748982 cites W2021758588 @default.
• W1833748982 cites W2022794334 @default.
• W1833748982 cites W2024849806 @default.
• W1833748982 cites W2025343005 @default.
• W1833748982 cites W2026446264 @default.
• W1833748982 cites W2026636731 @default.
• W1833748982 cites W2028360574 @default.
• W1833748982 cites W2028641849 @default.
• W1833748982 cites W2028991661 @default.
• W1833748982 cites W2029154645 @default.
• W1833748982 cites W2030032142 @default.
• W1833748982 cites W2032208190 @default.
• W1833748982 cites W2034174270 @default.
• W1833748982 cites W2035571697 @default.
• W1833748982 cites W2036557984 @default.
• W1833748982 cites W2039172398 @default.
• W1833748982 cites W2040219651 @default.
• W1833748982 cites W2040881424 @default.
• W1833748982 cites W2041598849 @default.
• W1833748982 cites W2042007405 @default.
• W1833748982 cites W2062036890 @default.
• W1833748982 cites W2062585588 @default.
• W1833748982 cites W2062616734 @default.
• W1833748982 cites W2063779005 @default.
• W1833748982 cites W2064390254 @default.
• W1833748982 cites W2072100512 @default.
• W1833748982 cites W2072572444 @default.
• W1833748982 cites W2076064293 @default.
• W1833748982 cites W2078479286 @default.
• W1833748982 cites W2082251318 @default.
• W1833748982 cites W2083011022 @default.
• W1833748982 cites W2083593344 @default.
• W1833748982 cites W2085688299 @default.
• W1833748982 cites W2086937931 @default.
• W1833748982 cites W2088510337 @default.
• W1833748982 cites W2088773436 @default.
• W1833748982 cites W2092654589 @default.
• W1833748982 cites W2096303371 @default.
• W1833748982 cites W2106145280 @default.
• W1833748982 cites W2110957675 @default.
• W1833748982 cites W2111024898 @default.
• W1833748982 cites W2113040555 @default.
• W1833748982 cites W2120552621 @default.
• W1833748982 cites W2126770863 @default.
• W1833748982 cites W2127733654 @default.
• W1833748982 cites W2131709992 @default.
• W1833748982 cites W2135241080 @default.
• W1833748982 cites W2140672532 @default.
• W1833748982 cites W2144065099 @default.
• W1833748982 cites W2144113323 @default.
• W1833748982 cites W2145733834 @default.
• W1833748982 cites W2158073187 @default.
• W1833748982 cites W2161886804 @default.
• W1833748982 cites W2212257225 @default.
• W1833748982 cites W2258348164 @default.
• W1833748982 cites W2293726883 @default.
• W1833748982 cites W2335178464 @default.
• W1833748982 cites W2406080168 @default.
• W1833748982 cites W2407876889 @default.
• W1833748982 cites W82383181 @default.
• W1833748982 hasPublicationYear "2013" @default.
• W1833748982 type Work @default.
• W1833748982 sameAs 1833748982 @default.
• W1833748982 citedByCount "0" @default.
• W1833748982 crossrefType "dissertation" @default.
• W1833748982 hasAuthorship W1833748982A5054587371 @default.
• W1833748982 hasConcept C1008401 @default.
• W1833748982 hasConcept C126322002 @default.
• W1833748982 hasConcept C126894567 @default.
• W1833748982 hasConcept C141071460 @default.
• W1833748982 hasConcept C168563851 @default.
• W1833748982 hasConcept C2776541429 @default.
• W1833748982 hasConcept C2776594446 @default.
• W1833748982 hasConcept C2776737378 @default.
• W1833748982 hasConcept C2776886416 @default.
• W1833748982 hasConcept C2777308945 @default.
• W1833748982 hasConcept C2781208988 @default.

• next