FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1833781582> ?p ?o ?g. }

• W1833781582 endingPage "615" @default.
• W1833781582 startingPage "605" @default.
• W1833781582 abstract "Treatment with HgCl2 induces a systemic autoimmune disease in certain mice and rats. The major characteristic of this disease in mice with H-2s genotype is the production of anti-nucleolar autoantibodies (ANolA). The exact mechanism(s) for the production and the functional role of mercury-induced ANolA are not known. We have studied the ability of mercury-induced ANolA to enter the living cells in vivo and in vitro. We found that in highly susceptible mice, treatment with mercury induced ANolA capable of localizing in the nucleoli of kidney and liver cells in vivo. No detectable nucleoli localization of ANolA were found in the cells of the heart, stomach, intestine and spleen. Consistent with the in vivo studies, mercury-induced ANolA were also able to enter and translocate in the nucleoli of certain cells in vitro. The highest degree of antibody penetration was found in A-498 cells (a human kidney cell line) followed by 3T3 cells (a mouse fibroblast cell line), whereas the cells of lymphoid origin exhibited a very low degree of antibody penetration. Penetrated ANolA could be recovered from the nucleoli of live 3T3 cells previously treated with ANolA. The in vitro nucleolar translocation by ANolA did not affect the DNA synthesis, but was found to be an active process dependent on time and temperature. Furthermore, pre-treatment of living cells with trypsin markedly inhibited both cell entry and nucleolar accumulation of ANolA. Thus, mercury-induced ANolA have a unique ability to transgress the membrane of certain living cells in vivo and in vitro, and to localize in the nucleoli." @default.
• W1833781582 created "2016-06-24" @default.
• W1833781582 creator A5031572164 @default.
• W1833781582 creator A5039353263 @default.
• W1833781582 creator A5065101788 @default.
• W1833781582 date "1999-04-01" @default.
• W1833781582 modified "2023-10-05" @default.
• W1833781582 title "Mercury-induced anti-nucleolar autoantibodies can transgress the membrane of living cells in vivo and in vitro" @default.
• W1833781582 cites W1520041405 @default.
• W1833781582 cites W1575401269 @default.
• W1833781582 cites W1643347750 @default.
• W1833781582 cites W1968927186 @default.
• W1833781582 cites W1970794864 @default.
• W1833781582 cites W1971577556 @default.
• W1833781582 cites W1979433399 @default.
• W1833781582 cites W1990917996 @default.
• W1833781582 cites W1997680593 @default.
• W1833781582 cites W1999158929 @default.
• W1833781582 cites W2007752780 @default.
• W1833781582 cites W2015597536 @default.
• W1833781582 cites W2025208802 @default.
• W1833781582 cites W2055715838 @default.
• W1833781582 cites W2074101291 @default.
• W1833781582 cites W2084308909 @default.
• W1833781582 cites W2090044525 @default.
• W1833781582 cites W2110295973 @default.
• W1833781582 cites W2120465956 @default.
• W1833781582 cites W2150915632 @default.
• W1833781582 cites W2158323899 @default.
• W1833781582 cites W2227157639 @default.
• W1833781582 cites W4251695548 @default.
• W1833781582 cites W4313313438 @default.
• W1833781582 doi "https://doi.org/10.1093/intimm/11.4.605" @default.
• W1833781582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10323214" @default.
• W1833781582 hasPublicationYear "1999" @default.
• W1833781582 type Work @default.
• W1833781582 sameAs 1833781582 @default.
• W1833781582 citedByCount "14" @default.
• W1833781582 countsByYear W18337815822012 @default.
• W1833781582 countsByYear W18337815822015 @default.
• W1833781582 countsByYear W18337815822016 @default.
• W1833781582 countsByYear W18337815822020 @default.
• W1833781582 countsByYear W18337815822022 @default.
• W1833781582 crossrefType "journal-article" @default.
• W1833781582 hasAuthorship W1833781582A5031572164 @default.
• W1833781582 hasAuthorship W1833781582A5039353263 @default.
• W1833781582 hasAuthorship W1833781582A5065101788 @default.
• W1833781582 hasBestOaLocation W18337815821 @default.
• W1833781582 hasConcept C150903083 @default.
• W1833781582 hasConcept C153911025 @default.
• W1833781582 hasConcept C159654299 @default.
• W1833781582 hasConcept C163764329 @default.
• W1833781582 hasConcept C183873130 @default.
• W1833781582 hasConcept C185592680 @default.
• W1833781582 hasConcept C190062978 @default.
• W1833781582 hasConcept C202751555 @default.
• W1833781582 hasConcept C203014093 @default.
• W1833781582 hasConcept C207001950 @default.
• W1833781582 hasConcept C2780931953 @default.
• W1833781582 hasConcept C54355233 @default.
• W1833781582 hasConcept C55493867 @default.
• W1833781582 hasConcept C81885089 @default.
• W1833781582 hasConcept C86803240 @default.
• W1833781582 hasConcept C95444343 @default.
• W1833781582 hasConceptScore W1833781582C150903083 @default.
• W1833781582 hasConceptScore W1833781582C153911025 @default.
• W1833781582 hasConceptScore W1833781582C159654299 @default.
• W1833781582 hasConceptScore W1833781582C163764329 @default.
• W1833781582 hasConceptScore W1833781582C183873130 @default.
• W1833781582 hasConceptScore W1833781582C185592680 @default.
• W1833781582 hasConceptScore W1833781582C190062978 @default.
• W1833781582 hasConceptScore W1833781582C202751555 @default.
• W1833781582 hasConceptScore W1833781582C203014093 @default.
• W1833781582 hasConceptScore W1833781582C207001950 @default.
• W1833781582 hasConceptScore W1833781582C2780931953 @default.
• W1833781582 hasConceptScore W1833781582C54355233 @default.
• W1833781582 hasConceptScore W1833781582C55493867 @default.
• W1833781582 hasConceptScore W1833781582C81885089 @default.
• W1833781582 hasConceptScore W1833781582C86803240 @default.
• W1833781582 hasConceptScore W1833781582C95444343 @default.
• W1833781582 hasIssue "4" @default.
• W1833781582 hasLocation W18337815821 @default.
• W1833781582 hasLocation W18337815822 @default.
• W1833781582 hasOpenAccess W1833781582 @default.
• W1833781582 hasPrimaryLocation W18337815821 @default.
• W1833781582 hasRelatedWork W1856085589 @default.
• W1833781582 hasRelatedWork W1933273068 @default.
• W1833781582 hasRelatedWork W2005137413 @default.
• W1833781582 hasRelatedWork W2020692772 @default.
• W1833781582 hasRelatedWork W2029209415 @default.
• W1833781582 hasRelatedWork W2072983387 @default.
• W1833781582 hasRelatedWork W2406420051 @default.
• W1833781582 hasRelatedWork W2428706351 @default.
• W1833781582 hasRelatedWork W2464301138 @default.
• W1833781582 hasRelatedWork W2183680114 @default.
• W1833781582 hasVolume "11" @default.
• W1833781582 isParatext "false" @default.
• W1833781582 isRetracted "false" @default.

• next