FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1834007800> ?p ?o ?g. }

• W1834007800 endingPage "2258" @default.
• W1834007800 startingPage "2247" @default.
• W1834007800 abstract "We report that the hindsight (hnt) gene, which encodes a nuclear zinc-finger protein, regulates cell morphology, cell fate specification, planar cell polarity and epithelial integrity during Drosophila retinal development. In the third instar larval eye imaginal disc, HNT protein expression begins in the morphogenetic furrow and is refined to cells in the developing photoreceptor cell clusters just before their determination as neurons. In hnt mutant larval eye tissue, furrow markers persist abnormally posterior to the furrow, there is a delay in specification of preclusters as cells exit the furrow, there are morphological defects in the preclusters and recruitment of cells into specific R cell fates often does not occur. Additionally, genetically mosaic ommatidia with one or more hnt mutant outer photoreceptor cells, have planar polarity defects that include achirality, reversed chirality and misrotation. Mutants in the JNK pathway act as dominant suppressors of the hnt planar polarity phenotype, suggesting that HNT functions to downregulate JUN kinase (JNK) signaling during the establishment of ommatidial planar polarity. HNT expression continues in the photoreceptor cells of the pupal retina. When an ommatidium contains four or more hnt mutant photoreceptor cells, both genetically mutant and genetically wild-type photoreceptor cells fall out of the retinal epithelium, indicating a role for HNT in maintenance of epithelial integrity. In the late pupal stages, HNT regulates the morphogenesis of rhabdomeres within individual photoreceptor cells and the separation of the rhabdomeres of adjacent photoreceptor cells. Apical F-actin is depleted in hnt mutant photoreceptor cells before the observed defects in cellular morphogenesis and epithelial integrity. The analyses presented here, together with our previous studies in the embryonic amnioserosa and tracheal system, show that HNT has a general role in regulation of the F-actin-based cytoskeleton, JNK signaling, cell morphology and epithelial integrity during development." @default.
• W1834007800 created "2016-06-24" @default.
• W1834007800 creator A5001784756 @default.
• W1834007800 creator A5043886318 @default.
• W1834007800 creator A5047146685 @default.
• W1834007800 creator A5084992927 @default.
• W1834007800 creator A5086433314 @default.
• W1834007800 date "2002-05-01" @default.
• W1834007800 modified "2023-10-16" @default.
• W1834007800 title "Control of photoreceptor cell morphology, planar polarity and epithelial integrity during<i>Drosophila</i>eye development" @default.
• W1834007800 cites W1828379386 @default.
• W1834007800 cites W1862548240 @default.
• W1834007800 cites W1882780242 @default.
• W1834007800 cites W1892778056 @default.
• W1834007800 cites W1967062108 @default.
• W1834007800 cites W1971855104 @default.
• W1834007800 cites W1973110478 @default.
• W1834007800 cites W1977052613 @default.
• W1834007800 cites W1980157632 @default.
• W1834007800 cites W1981343617 @default.
• W1834007800 cites W1981566818 @default.
• W1834007800 cites W1983449869 @default.
• W1834007800 cites W1984453334 @default.
• W1834007800 cites W1984739916 @default.
• W1834007800 cites W1991631964 @default.
• W1834007800 cites W1993593119 @default.
• W1834007800 cites W1993654209 @default.
• W1834007800 cites W2018887997 @default.
• W1834007800 cites W2040136439 @default.
• W1834007800 cites W2041372335 @default.
• W1834007800 cites W2046123732 @default.
• W1834007800 cites W2047531379 @default.
• W1834007800 cites W2051202415 @default.
• W1834007800 cites W2059444422 @default.
• W1834007800 cites W2062089405 @default.
• W1834007800 cites W2077586139 @default.
• W1834007800 cites W2087624263 @default.
• W1834007800 cites W2097473249 @default.
• W1834007800 cites W2103235250 @default.
• W1834007800 cites W2111976316 @default.
• W1834007800 cites W2115351454 @default.
• W1834007800 cites W2127251425 @default.
• W1834007800 cites W2142916161 @default.
• W1834007800 cites W2148736507 @default.
• W1834007800 cites W2153561150 @default.
• W1834007800 cites W2157740912 @default.
• W1834007800 cites W2159935247 @default.
• W1834007800 cites W2168137103 @default.
• W1834007800 cites W2169988786 @default.
• W1834007800 cites W2183318287 @default.
• W1834007800 cites W2272180841 @default.
• W1834007800 cites W2343698626 @default.
• W1834007800 cites W2405495734 @default.
• W1834007800 cites W4238848641 @default.
• W1834007800 doi "https://doi.org/10.1242/dev.129.9.2247" @default.
• W1834007800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11959832" @default.
• W1834007800 hasPublicationYear "2002" @default.
• W1834007800 type Work @default.
• W1834007800 sameAs 1834007800 @default.
• W1834007800 citedByCount "33" @default.
• W1834007800 countsByYear W18340078002013 @default.
• W1834007800 countsByYear W18340078002014 @default.
• W1834007800 countsByYear W18340078002015 @default.
• W1834007800 countsByYear W18340078002016 @default.
• W1834007800 countsByYear W18340078002017 @default.
• W1834007800 countsByYear W18340078002018 @default.
• W1834007800 countsByYear W18340078002019 @default.
• W1834007800 countsByYear W18340078002020 @default.
• W1834007800 countsByYear W18340078002021 @default.
• W1834007800 countsByYear W18340078002022 @default.
• W1834007800 countsByYear W18340078002023 @default.
• W1834007800 crossrefType "journal-article" @default.
• W1834007800 hasAuthorship W1834007800A5001784756 @default.
• W1834007800 hasAuthorship W1834007800A5043886318 @default.
• W1834007800 hasAuthorship W1834007800A5047146685 @default.
• W1834007800 hasAuthorship W1834007800A5084992927 @default.
• W1834007800 hasAuthorship W1834007800A5086433314 @default.
• W1834007800 hasConcept C104317684 @default.
• W1834007800 hasConcept C114696181 @default.
• W1834007800 hasConcept C120665830 @default.
• W1834007800 hasConcept C121332964 @default.
• W1834007800 hasConcept C127716648 @default.
• W1834007800 hasConcept C143065580 @default.
• W1834007800 hasConcept C1491633281 @default.
• W1834007800 hasConcept C169760540 @default.
• W1834007800 hasConcept C2777093970 @default.
• W1834007800 hasConcept C2780916184 @default.
• W1834007800 hasConcept C2909722775 @default.
• W1834007800 hasConcept C40692019 @default.
• W1834007800 hasConcept C49353375 @default.
• W1834007800 hasConcept C50213807 @default.
• W1834007800 hasConcept C54355233 @default.
• W1834007800 hasConcept C86803240 @default.
• W1834007800 hasConcept C91986751 @default.
• W1834007800 hasConcept C95444343 @default.
• W1834007800 hasConceptScore W1834007800C104317684 @default.
• W1834007800 hasConceptScore W1834007800C114696181 @default.
• W1834007800 hasConceptScore W1834007800C120665830 @default.

• next