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- W1834171181 endingPage "398" @default.
- W1834171181 startingPage "373" @default.
- W1834171181 abstract "Connexin (Cx) and pannexin (Panx) proteins form large conductance channels, which function as regulators of communication between neighbouring cells via gap junctions and/or hemichannels. Intercellular communication is essential to coordinate cellular responses in tissues and organs, thereby fulfilling an essential role in the spreading of signalling, survival and death processes. The functional properties of gap junctions and hemichannels are modulated by different physiological and pathophysiological stimuli. At the molecular level, Cxs and Panxs function as multi‐protein channel complexes, regulating their channel localisation and activity. In addition to this, gap junctional channels and hemichannels are modulated by different post‐translational modifications (PTMs), including phosphorylation, glycosylation, proteolysis, N‐acetylation, S‐nitrosylation, ubiquitination, lipidation, hydroxylation, methylation and deamidation. These PTMs influence almost all aspects of communicating junctional channels in normal cell biology and pathophysiology. In this review, we will provide a systematic overview of PTMs of communicating junction proteins and discuss their effects on Cx and Panx‐channel activity and localisation." @default.
- W1834171181 created "2016-06-24" @default.
- W1834171181 creator A5002784436 @default.
- W1834171181 creator A5008668373 @default.
- W1834171181 creator A5019565239 @default.
- W1834171181 creator A5032340086 @default.
- W1834171181 creator A5045862213 @default.
- W1834171181 creator A5058565678 @default.
- W1834171181 creator A5065437445 @default.
- W1834171181 date "2013-07-17" @default.
- W1834171181 modified "2023-10-17" @default.
- W1834171181 title "Regulation of connexin- and pannexin-based channels by post-translational modifications" @default.
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