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- W1834217090 abstract "Background Acquired haemophilia A (AHA) is a rare medical emergency that may be characterised by severe and life-threatening haemorrhage. Aims This case report highlights the need for a better awareness of this disorder in terms of diagnosis and urgent management. Materials and Methods This is a clinical presentation of a 77-year-old Caucasian man who presented to Accident and Emergency with profuse bleeding from his tongue, secondary to mechanical trauma. Local haemostatic measures were only temporarily effective as he returned on a further five occasions over a 3-week period with recurrent bleeding from the same site. A coagulation screen revealed prolongation of the activated partial thromboplastin time that did not correct on a 50/50 mixing study with normal plasma. Subsequent analysis of intrinsic coagulation factor activity levels revealed severe factor VIII (FVIII) deficiency. A high-titre FVIII inhibitor was identified in his plasma and the diagnosis of AHA was made. The patient was promptly transferred to the regional haemophilia comprehensive care centre for specialist management. Discussion AHA should be suspected in a patient with no personal or family history of a bleeding disorder who presents with soft tissue haemorrhage unresponsive to local measures. Conclusion This condition is particularly relevant to dental clinicians as patients may present with oral clinical signs of disease. In addition, affected individuals are also at risk of severe haemorrhage following accidental trauma or invasive oral surgery procedures." @default.
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- W1834217090 date "2012-09-18" @default.
- W1834217090 modified "2023-10-14" @default.
- W1834217090 title "Acquired haemophilia A: a clinical case" @default.
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- W1834217090 doi "https://doi.org/10.1111/j.1752-248x.2012.01169.x" @default.
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