FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1834496657> ?p ?o ?g. }

• W1834496657 endingPage "40" @default.
• W1834496657 startingPage "33" @default.
• W1834496657 abstract "Overexpression of the Aurora A kinase has been shown to have prognostic value in breast cancer. Previously, we showed a significant association between AURKA gene amplification and BRCA2 mutation in breast cancer. The aim of this study was to assess the prognostic impact of Aurora A overexpression on breast cancer arising in BRCA2 mutation carriers. Aurora A expression was evaluated by immunohistochemistry on breast tumour tissue microarrays from 107 BRCA2 999del5 mutation carriers and 284 of sporadic origin. Prognostic value of Aurora A nuclear staining was estimated in relation to clinical markers and adjuvant treatment, using multivariate Cox's proportional hazards ratio regression model. BRCA2 wild-type allele loss was measured by TaqMan in BRCA2 mutated tumour samples. All statistical tests were two sided. Multivariate analysis of breast cancer-specific survival, including proliferative markers and treatment, indicated independent prognostic value of Aurora A nuclear staining for BRCA2 mutation carriers (hazards ratio = 7.06; 95% confidence interval = 1.23-40.6; p = 0.028). Poor breast cancer-specific survival of BRCA2 mutation carriers was found to be significantly associated with combined Aurora A nuclear expression and BRCA2 wild type allele loss in tumours (p < 0.001). Multivariate analysis indicated independent prognostic value of both positive Aurora A nuclear staining (hazards ratio = 10.09; 95% confidence interval = 1.19-85.4, p = 0.034) and BRCA2 wild type allele loss (hazards ratio = 9.63; 95% confidence interval = 1.81-51.0, p = 0.008) for BRCA2 mutation carriers. Aurora A nuclear expression was found to be a significant prognostic marker for BRCA2 mutation carriers, independent of clinical parameters and adjuvant treatment. Our conclusion is that treatment benefits for BRCA2 mutation carriers and sporadic breast cancer patients with Aurora A positive tumours may be enhanced by giving attention to Aurora A targeted treatment." @default.
• W1834496657 created "2016-06-24" @default.
• W1834496657 creator A5003459358 @default.
• W1834496657 creator A5006300810 @default.
• W1834496657 creator A5014267065 @default.
• W1834496657 creator A5031425387 @default.
• W1834496657 creator A5047819372 @default.
• W1834496657 creator A5086006915 @default.
• W1834496657 creator A5088756291 @default.
• W1834496657 creator A5089161989 @default.
• W1834496657 date "2014-11-07" @default.
• W1834496657 modified "2023-10-16" @default.
• W1834496657 title "Aurora A is a prognostic marker for breast cancer arising in<i>BRCA2</i>mutation carriers" @default.
• W1834496657 cites W1558862631 @default.
• W1834496657 cites W1657157395 @default.
• W1834496657 cites W1844282257 @default.
• W1834496657 cites W1967350255 @default.
• W1834496657 cites W1970578083 @default.
• W1834496657 cites W1980150890 @default.
• W1834496657 cites W1982755610 @default.
• W1834496657 cites W1983343150 @default.
• W1834496657 cites W1989320136 @default.
• W1834496657 cites W1991016920 @default.
• W1834496657 cites W1992181243 @default.
• W1834496657 cites W1993732086 @default.
• W1834496657 cites W2006113261 @default.
• W1834496657 cites W2007270591 @default.
• W1834496657 cites W2011980989 @default.
• W1834496657 cites W2027763931 @default.
• W1834496657 cites W2034871240 @default.
• W1834496657 cites W2036573101 @default.
• W1834496657 cites W2037463541 @default.
• W1834496657 cites W2047581860 @default.
• W1834496657 cites W2049876223 @default.
• W1834496657 cites W2053950888 @default.
• W1834496657 cites W2060791420 @default.
• W1834496657 cites W2064016192 @default.
• W1834496657 cites W2069910776 @default.
• W1834496657 cites W2080356726 @default.
• W1834496657 cites W2083352151 @default.
• W1834496657 cites W2085770388 @default.
• W1834496657 cites W2087384165 @default.
• W1834496657 cites W2093549611 @default.
• W1834496657 cites W2094512665 @default.
• W1834496657 cites W2106119561 @default.
• W1834496657 cites W2112289645 @default.
• W1834496657 cites W2116565287 @default.
• W1834496657 cites W2118146226 @default.
• W1834496657 cites W2120160086 @default.
• W1834496657 cites W2125482729 @default.
• W1834496657 cites W2126005827 @default.
• W1834496657 cites W2134296571 @default.
• W1834496657 cites W2142509184 @default.
• W1834496657 cites W2142565191 @default.
• W1834496657 cites W2143580072 @default.
• W1834496657 cites W2146982832 @default.
• W1834496657 cites W2147162963 @default.
• W1834496657 cites W2164459004 @default.
• W1834496657 cites W2330617033 @default.
• W1834496657 cites W4239909851 @default.
• W1834496657 doi "https://doi.org/10.1002/cjp2.6" @default.
• W1834496657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4858119" @default.
• W1834496657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27499891" @default.
• W1834496657 hasPublicationYear "2014" @default.
• W1834496657 type Work @default.
• W1834496657 sameAs 1834496657 @default.
• W1834496657 citedByCount "19" @default.
• W1834496657 countsByYear W18344966572015 @default.
• W1834496657 countsByYear W18344966572016 @default.
• W1834496657 countsByYear W18344966572017 @default.
• W1834496657 countsByYear W18344966572018 @default.
• W1834496657 countsByYear W18344966572019 @default.
• W1834496657 countsByYear W18344966572020 @default.
• W1834496657 countsByYear W18344966572021 @default.
• W1834496657 countsByYear W18344966572022 @default.
• W1834496657 countsByYear W18344966572023 @default.
• W1834496657 crossrefType "journal-article" @default.
• W1834496657 hasAuthorship W1834496657A5003459358 @default.
• W1834496657 hasAuthorship W1834496657A5006300810 @default.
• W1834496657 hasAuthorship W1834496657A5014267065 @default.
• W1834496657 hasAuthorship W1834496657A5031425387 @default.
• W1834496657 hasAuthorship W1834496657A5047819372 @default.
• W1834496657 hasAuthorship W1834496657A5086006915 @default.
• W1834496657 hasAuthorship W1834496657A5088756291 @default.
• W1834496657 hasAuthorship W1834496657A5089161989 @default.
• W1834496657 hasBestOaLocation W18344966571 @default.
• W1834496657 hasConcept C104317684 @default.
• W1834496657 hasConcept C121608353 @default.
• W1834496657 hasConcept C126322002 @default.
• W1834496657 hasConcept C142724271 @default.
• W1834496657 hasConcept C143998085 @default.
• W1834496657 hasConcept C193270364 @default.
• W1834496657 hasConcept C44249647 @default.
• W1834496657 hasConcept C501734568 @default.
• W1834496657 hasConcept C502942594 @default.
• W1834496657 hasConcept C50382708 @default.
• W1834496657 hasConcept C530470458 @default.
• W1834496657 hasConcept C54355233 @default.

• next