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• W1834689742 endingPage "228" @default.
• W1834689742 startingPage "214" @default.
• W1834689742 abstract "Archaea microorganisms have long been used as model organisms for the study of protein molecular machines. Archaeal proteins are particularly appealing to study since archaea, even though prokaryotic, possess eukaryotic-like cellular processes. Super Family I (SF1) and Super Family II (SF2) helicase families have been studied in many model organisms, little is known about their presence and distribution in archaea. We performed an exhaustive search of homologs of SF1 and SF2 helicase proteins in 95 complete archaeal genomes. In the present study, we identified the complete sets of SF1 and SF2 helicases in archaea. Comparative analysis between archaea, human and the bacteria E. coli SF1 and SF2 helicases, resulted in the identification of seven helicase families conserved among representatives of the domains of life. This analysis suggests that these helicase families are highly conserved throughout evolution. We highlight the conserved motifs of each family and characteristic domains of the detected families. Distribution of SF1/SF2 families show that Ski2-like, Lhr, Sfth and Rad3-like helicases are ubiquitous among archaeal genomes while the other families are specific to certain archaeal groups. We also report the presence of a novel SF2 helicase specific to archaea domain named Archaea Specific Helicase (ASH). Phylogenetic analysis indicated that ASH has evolved in Euryarchaeota and is evolutionary related to the Ski2-like family with specific characteristic domains. Our study provides the first exhaustive analysis of SF1 and SF2 helicases from archaea. It expands the variety of SF1 and SF2 archaeal helicases known to exist to date and provides a starting point for new biochemical and genetic studies needed to validate their biological functions." @default.
• W1834689742 created "2016-06-24" @default.
• W1834689742 creator A5015507887 @default.
• W1834689742 creator A5022290027 @default.
• W1834689742 creator A5067906969 @default.
• W1834689742 date "2016-01-01" @default.
• W1834689742 modified "2023-09-27" @default.
• W1834689742 title "Genome-wide identification of SF1 and SF2 helicases from archaea" @default.
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• W1834689742 doi "https://doi.org/10.1016/j.gene.2015.10.007" @default.

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