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- W1834729197 endingPage "421" @default.
- W1834729197 startingPage "414" @default.
- W1834729197 abstract "Colorectal cancer stem cells (CSCs) were initially considered to be a subset of undifferentiated tumor cells with well-defined phenotypic and molecular markers. However, emerging evidence indicates instead that colorectal CSCs are heterogeneous subsets of tumor cells that are continuously reshaped by the dynamic interactions between genetic, epigenetic, and immune factors in the tumor microenvironment. Thus, the colorectal CSC phenotypes and responsiveness to therapy may not only be a tumor cell-intrinsic feature, but also depend on tumor-extrinsic microenvironmental factors. Furthermore, emerging evidence also implicates colorectal CSCs in potential immune evasion. Therefore, understanding how colorectal CSC-intrinsic mechanisms cooperate with the extrinsic microenvironmental factors to dynamically shape colorectal CSC resistance to chemotherapy and immunotherapy holds great promise for development of targeted CSC therapies of advanced human CRC." @default.
- W1834729197 created "2016-06-24" @default.
- W1834729197 creator A5016580028 @default.
- W1834729197 creator A5063745052 @default.
- W1834729197 date "2015-10-10" @default.
- W1834729197 modified "2023-10-11" @default.
- W1834729197 title "Epigenetic and Immune Regulation of Colorectal Cancer Stem Cells" @default.
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