FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1835516666> ?p ?o ?g. }

• W1835516666 abstract "Massively parallel DNA and RNA sequencing approaches have generated high dimensional data on thousands of breast cancer genomes. Broad-based conclusions include challenges to the multistep model of breast carcinogenesis and the monoclonality of cancer, a link between leukemogenesis and luminal breast cancer and the discovery of new mutagenesis mechanisms. Unfortunately novel and immediately applicable therapeutic insights have been somewhat sparse. Many of the processes that are disrupted by newly discovered somatic mutations include genes with roles in splicing, histone methylation and long non-coding RNA function. Drugs targeting these processes are in the earliest stages of development, emphasizing a pressing unmet need to move drug discovery efforts beyond our current intense focus on kinase inhibitors. Despite the evident complexity, promising examples are emerging including new efforts to target mutations in two well-established drivers in breast cancer: HER2 in HER2 mutant breast cancer and mutant ESR1 in ESR1 endocrine refractory luminal-type breast cancer. A case for the importance of genome-annotated patient-derived breast cancer xenografts (PDX) will also be made. PDX models are potentially more reliable preclinical setting than cell lines and are a setting in which the biological rules for genome driven therapeutic planning could be developed. A call is also made for a new generation of prospective clinical trials that are fully focused on exploring interactions between cancer genomics and drug outcomes as a primary objective. Finally the integration of DNA and RNA based sequencing studies with mass-spectrometry-based peptide sequencing promises a more complete view of the biochemistry of breast cancer cells and represents a new discovery horizon in efforts to drug the pathophysiology of complex epithelial malignancies. Citation Format: Matthew J. Ellis. Mutations, drugs, and breast cancer: How are we going to figure it out? [abstract]. In: Proceedings of the AACR Precision Medicine Series: Drug Sensitivity and Resistance: Improving Cancer Therapy; Jun 18-21, 2014; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(4 Suppl): Abstract nr IA03." @default.
• W1835516666 created "2016-06-24" @default.
• W1835516666 creator A5057135409 @default.
• W1835516666 date "2015-02-13" @default.
• W1835516666 modified "2023-09-26" @default.
• W1835516666 title "Abstract IA03: Mutations, drugs, and breast cancer: How are we going to figure it out?" @default.
• W1835516666 doi "https://doi.org/10.1158/1557-3265.pms14-ia03" @default.
• W1835516666 hasPublicationYear "2015" @default.
• W1835516666 type Work @default.
• W1835516666 sameAs 1835516666 @default.
• W1835516666 citedByCount "0" @default.
• W1835516666 crossrefType "proceedings-article" @default.
• W1835516666 hasAuthorship W1835516666A5057135409 @default.
• W1835516666 hasConcept C121608353 @default.
• W1835516666 hasConcept C502942594 @default.
• W1835516666 hasConcept C530470458 @default.
• W1835516666 hasConcept C54355233 @default.
• W1835516666 hasConcept C555283112 @default.
• W1835516666 hasConcept C60644358 @default.
• W1835516666 hasConcept C70721500 @default.
• W1835516666 hasConcept C74187038 @default.
• W1835516666 hasConcept C86803240 @default.
• W1835516666 hasConceptScore W1835516666C121608353 @default.
• W1835516666 hasConceptScore W1835516666C502942594 @default.
• W1835516666 hasConceptScore W1835516666C530470458 @default.
• W1835516666 hasConceptScore W1835516666C54355233 @default.
• W1835516666 hasConceptScore W1835516666C555283112 @default.
• W1835516666 hasConceptScore W1835516666C60644358 @default.
• W1835516666 hasConceptScore W1835516666C70721500 @default.
• W1835516666 hasConceptScore W1835516666C74187038 @default.
• W1835516666 hasConceptScore W1835516666C86803240 @default.
• W1835516666 hasLocation W18355166661 @default.
• W1835516666 hasOpenAccess W1835516666 @default.
• W1835516666 hasPrimaryLocation W18355166661 @default.
• W1835516666 hasRelatedWork W1129553077 @default.
• W1835516666 hasRelatedWork W1543944384 @default.
• W1835516666 hasRelatedWork W2041736261 @default.
• W1835516666 hasRelatedWork W2080048051 @default.
• W1835516666 hasRelatedWork W2080973679 @default.
• W1835516666 hasRelatedWork W2081437658 @default.
• W1835516666 hasRelatedWork W2156140763 @default.
• W1835516666 hasRelatedWork W2190879643 @default.
• W1835516666 hasRelatedWork W2346434468 @default.
• W1835516666 hasRelatedWork W2407367612 @default.
• W1835516666 hasRelatedWork W2460590704 @default.
• W1835516666 hasRelatedWork W2594842994 @default.
• W1835516666 hasRelatedWork W2616865409 @default.
• W1835516666 hasRelatedWork W2903817533 @default.
• W1835516666 hasRelatedWork W2917709958 @default.
• W1835516666 hasRelatedWork W2937107212 @default.
• W1835516666 hasRelatedWork W3012014129 @default.
• W1835516666 hasRelatedWork W3044002837 @default.
• W1835516666 hasRelatedWork W3207704881 @default.
• W1835516666 hasRelatedWork W774595448 @default.
• W1835516666 isParatext "false" @default.
• W1835516666 isRetracted "false" @default.
• W1835516666 magId "1835516666" @default.
• W1835516666 workType "article" @default.