FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1835869439> ?p ?o ?g. }

• W1835869439 endingPage "1006" @default.
• W1835869439 startingPage "997" @default.
• W1835869439 abstract "Infections or inflammatory states often cause significant increases in serum phenylalanine and the phenylalanine-tyrosine ratio. More than 95% of samples obtained during inflammatory diseases in man showed phenylalanine-tyrosine ratio increases greater than the maximum normal values. An increase in this ratio also occurred in monkeys with induced Rocky Mountain spotted fever, viral encephalitis, yellow fever, or pneumococcal and Salmonella infections, as well as in rats with pneumococcal and Salmonella infections, as well as in rats with pneumococcal, Salmonella or tularemia infections. A similar ratio increase occurred in rats inoculated with unpurified mediator substances (released by activated leukocytes) that appear to initiate many of the secondary metabolic phenomena associated with infection and/or inflammation. To identify responsible mechanisms, rats were given lethal doses of Streptococcus pneumoniae: serum phenylalanine and phenylalanine-tyrosine ratios increased significantly. Hepatic phenylalanine hydroxylase activities were slightly decreased when compared to noninfected controls. Infected and noninfected rats showed comparable oxidation rates for 14C-phenylalanine given with an oral phenylalanine load, as a pulse-oral dose, or as an intraperitoneal injection. After 8 hr, both infected and control rats had similar amounts of radioactivity in total body protein, but tissue distributions were markedly altered during pneumococcal sepsis. Serum proteins of infected rats contained almost twice as much total radioactivity as that found in controls, while the amount of labeled phenylalanine in skeletal muscle protein was significantly reduced in the infected group. Isolated muscles from infected rats released more phenylalanine and less tyrosine than control muscles. Infection-related increases in serum phenylalanine could not be explained by decreased hydroxylation or oxidation. Rather, the data were consistent with an increased flux of phenylalanine into serum, most likely as the result of increased skeletal muscle catabolism. Elevations in the serum phenylalanine-tyrosine ratio have potential value for estimating the presence of an inflammatory disease and the catabolic state of a patient." @default.
• W1835869439 created "2016-06-24" @default.
• W1835869439 creator A5032082255 @default.
• W1835869439 creator A5050356462 @default.
• W1835869439 creator A5054355066 @default.
• W1835869439 creator A5061193719 @default.
• W1835869439 date "1976-09-01" @default.
• W1835869439 modified "2023-10-16" @default.
• W1835869439 title "The significance and mechanism of an increased serum phenylalanine-tyrosine ratio during infection" @default.
• W1835869439 cites W123942096 @default.
• W1835869439 cites W1483387535 @default.
• W1835869439 cites W1533557828 @default.
• W1835869439 cites W1804765208 @default.
• W1835869439 cites W1853971520 @default.
• W1835869439 cites W1865953925 @default.
• W1835869439 cites W1876798024 @default.
• W1835869439 cites W1914460617 @default.
• W1835869439 cites W1958179630 @default.
• W1835869439 cites W1967407612 @default.
• W1835869439 cites W1969486962 @default.
• W1835869439 cites W1982565419 @default.
• W1835869439 cites W1995471724 @default.
• W1835869439 cites W1996342805 @default.
• W1835869439 cites W1996755666 @default.
• W1835869439 cites W2020327828 @default.
• W1835869439 cites W2049717393 @default.
• W1835869439 cites W2069791682 @default.
• W1835869439 cites W2071633123 @default.
• W1835869439 cites W2075225730 @default.
• W1835869439 cites W2079264512 @default.
• W1835869439 cites W2122288730 @default.
• W1835869439 cites W2234422390 @default.
• W1835869439 cites W2334709403 @default.
• W1835869439 cites W2411609865 @default.
• W1835869439 cites W4300154710 @default.
• W1835869439 doi "https://doi.org/10.1093/ajcn/29.9.997" @default.
• W1835869439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/822705" @default.
• W1835869439 hasPublicationYear "1976" @default.
• W1835869439 type Work @default.
• W1835869439 sameAs 1835869439 @default.
• W1835869439 citedByCount "138" @default.
• W1835869439 countsByYear W18358694392012 @default.
• W1835869439 countsByYear W18358694392013 @default.
• W1835869439 countsByYear W18358694392014 @default.
• W1835869439 countsByYear W18358694392015 @default.
• W1835869439 countsByYear W18358694392017 @default.
• W1835869439 countsByYear W18358694392018 @default.
• W1835869439 countsByYear W18358694392019 @default.
• W1835869439 countsByYear W18358694392020 @default.
• W1835869439 countsByYear W18358694392021 @default.
• W1835869439 countsByYear W18358694392022 @default.
• W1835869439 countsByYear W18358694392023 @default.
• W1835869439 crossrefType "journal-article" @default.
• W1835869439 hasAuthorship W1835869439A5032082255 @default.
• W1835869439 hasAuthorship W1835869439A5050356462 @default.
• W1835869439 hasAuthorship W1835869439A5054355066 @default.
• W1835869439 hasAuthorship W1835869439A5061193719 @default.
• W1835869439 hasBestOaLocation W18358694391 @default.
• W1835869439 hasConcept C126322002 @default.
• W1835869439 hasConcept C134018914 @default.
• W1835869439 hasConcept C185592680 @default.
• W1835869439 hasConcept C203014093 @default.
• W1835869439 hasConcept C2776165026 @default.
• W1835869439 hasConcept C2777431362 @default.
• W1835869439 hasConcept C2781253189 @default.
• W1835869439 hasConcept C501593827 @default.
• W1835869439 hasConcept C515207424 @default.
• W1835869439 hasConcept C55493867 @default.
• W1835869439 hasConcept C71924100 @default.
• W1835869439 hasConcept C86803240 @default.
• W1835869439 hasConcept C89423630 @default.
• W1835869439 hasConceptScore W1835869439C126322002 @default.
• W1835869439 hasConceptScore W1835869439C134018914 @default.
• W1835869439 hasConceptScore W1835869439C185592680 @default.
• W1835869439 hasConceptScore W1835869439C203014093 @default.
• W1835869439 hasConceptScore W1835869439C2776165026 @default.
• W1835869439 hasConceptScore W1835869439C2777431362 @default.
• W1835869439 hasConceptScore W1835869439C2781253189 @default.
• W1835869439 hasConceptScore W1835869439C501593827 @default.
• W1835869439 hasConceptScore W1835869439C515207424 @default.
• W1835869439 hasConceptScore W1835869439C55493867 @default.
• W1835869439 hasConceptScore W1835869439C71924100 @default.
• W1835869439 hasConceptScore W1835869439C86803240 @default.
• W1835869439 hasConceptScore W1835869439C89423630 @default.
• W1835869439 hasIssue "9" @default.
• W1835869439 hasLocation W18358694391 @default.
• W1835869439 hasLocation W18358694392 @default.
• W1835869439 hasOpenAccess W1835869439 @default.
• W1835869439 hasPrimaryLocation W18358694391 @default.
• W1835869439 hasRelatedWork W1513881935 @default.
• W1835869439 hasRelatedWork W1966404258 @default.
• W1835869439 hasRelatedWork W2000188123 @default.
• W1835869439 hasRelatedWork W2034910577 @default.
• W1835869439 hasRelatedWork W2051259433 @default.
• W1835869439 hasRelatedWork W2054293840 @default.
• W1835869439 hasRelatedWork W2066530401 @default.
• W1835869439 hasRelatedWork W2078780432 @default.
• W1835869439 hasRelatedWork W2147153749 @default.

• next