FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1836008096> ?p ?o ?g. }

• W1836008096 endingPage "2722" @default.
• W1836008096 startingPage "2717" @default.
• W1836008096 abstract "Mitochondria underpin energy conversion in eukaryotes. Their small genomes have been the subject of increasing attention, and there is evidence that mitochondrial genetic variation can affect evolutionary trajectories and shape the expression of life-history traits considered to be key human health indicators [1, 2]. However, it is not understood how genetic variation across a diminutive genome, which in most species harbors only about a dozen protein-coding genes, can exert broad-scale effects on the organismal phenotype [2, 3]. Such effects are particularly puzzling given that the mitochondrial genes involved are under strong evolutionary constraint and that mitochondrial gene expression is highly conserved across diverse taxa [4]. We used replicated genetic lines in the fruit fly, Drosophila melanogaster, each characterized by a distinct and naturally occurring mitochondrial haplotype placed alongside an isogenic nuclear background. We demonstrate that sequence variation within the mitochondrial DNA (mtDNA) affects both the copy number of mitochondrial genomes and patterns of gene expression across key mitochondrial protein-coding genes. In several cases, haplotype-mediated patterns of gene expression were gene-specific, even for genes from within the same transcriptional units. This invokes post-transcriptional processing of RNA in the regulation of mitochondrial genetic effects on organismal phenotypes. Notably, the haplotype-mediated effects on gene expression could be traced backward to the level of individual nucleotides and forward to sex-specific effects on fertility and longevity. Our study thus elucidates how small-scale sequence changes in the mitochondrial genome can achieve broad-scale regulation of health-related phenotypes and even contribute to sex-related differences in longevity." @default.
• W1836008096 created "2016-06-24" @default.
• W1836008096 creator A5056827323 @default.
• W1836008096 creator A5085092943 @default.
• W1836008096 creator A5086305462 @default.
• W1836008096 creator A5087971254 @default.
• W1836008096 date "2015-10-01" @default.
• W1836008096 modified "2023-10-15" @default.
• W1836008096 title "Single Nucleotides in the mtDNA Sequence Modify Mitochondrial Molecular Function and Are Associated with Sex-Specific Effects on Fertility and Aging" @default.
• W1836008096 cites W1577577364 @default.
• W1836008096 cites W1978274195 @default.
• W1836008096 cites W1985101349 @default.
• W1836008096 cites W1990401969 @default.
• W1836008096 cites W1993763031 @default.
• W1836008096 cites W1995962773 @default.
• W1836008096 cites W2004717931 @default.
• W1836008096 cites W2015188164 @default.
• W1836008096 cites W2022369816 @default.
• W1836008096 cites W2025677691 @default.
• W1836008096 cites W2030187372 @default.
• W1836008096 cites W2048303531 @default.
• W1836008096 cites W2060556723 @default.
• W1836008096 cites W2064879869 @default.
• W1836008096 cites W2068664302 @default.
• W1836008096 cites W2080280611 @default.
• W1836008096 cites W2093311238 @default.
• W1836008096 cites W2096977971 @default.
• W1836008096 cites W2101111866 @default.
• W1836008096 cites W2112716048 @default.
• W1836008096 cites W2119043579 @default.
• W1836008096 cites W2119306816 @default.
• W1836008096 cites W2123331734 @default.
• W1836008096 cites W2123904806 @default.
• W1836008096 cites W2129869148 @default.
• W1836008096 cites W2130680472 @default.
• W1836008096 cites W2138581811 @default.
• W1836008096 cites W2142264343 @default.
• W1836008096 cites W2156313234 @default.
• W1836008096 cites W2158030172 @default.
• W1836008096 cites W4249962361 @default.
• W1836008096 doi "https://doi.org/10.1016/j.cub.2015.09.012" @default.
• W1836008096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26455309" @default.
• W1836008096 hasPublicationYear "2015" @default.
• W1836008096 type Work @default.
• W1836008096 sameAs 1836008096 @default.
• W1836008096 citedByCount "89" @default.
• W1836008096 countsByYear W18360080962016 @default.
• W1836008096 countsByYear W18360080962017 @default.
• W1836008096 countsByYear W18360080962018 @default.
• W1836008096 countsByYear W18360080962019 @default.
• W1836008096 countsByYear W18360080962020 @default.
• W1836008096 countsByYear W18360080962021 @default.
• W1836008096 countsByYear W18360080962022 @default.
• W1836008096 countsByYear W18360080962023 @default.
• W1836008096 crossrefType "journal-article" @default.
• W1836008096 hasAuthorship W1836008096A5056827323 @default.
• W1836008096 hasAuthorship W1836008096A5085092943 @default.
• W1836008096 hasAuthorship W1836008096A5086305462 @default.
• W1836008096 hasAuthorship W1836008096A5087971254 @default.
• W1836008096 hasBestOaLocation W18360080961 @default.
• W1836008096 hasConcept C104317684 @default.
• W1836008096 hasConcept C127716648 @default.
• W1836008096 hasConcept C141231307 @default.
• W1836008096 hasConcept C151994961 @default.
• W1836008096 hasConcept C180754005 @default.
• W1836008096 hasConcept C197754878 @default.
• W1836008096 hasConcept C20750100 @default.
• W1836008096 hasConcept C24586158 @default.
• W1836008096 hasConcept C2780104201 @default.
• W1836008096 hasConcept C28859421 @default.
• W1836008096 hasConcept C54355233 @default.
• W1836008096 hasConcept C78458016 @default.
• W1836008096 hasConcept C86803240 @default.
• W1836008096 hasConceptScore W1836008096C104317684 @default.
• W1836008096 hasConceptScore W1836008096C127716648 @default.
• W1836008096 hasConceptScore W1836008096C141231307 @default.
• W1836008096 hasConceptScore W1836008096C151994961 @default.
• W1836008096 hasConceptScore W1836008096C180754005 @default.
• W1836008096 hasConceptScore W1836008096C197754878 @default.
• W1836008096 hasConceptScore W1836008096C20750100 @default.
• W1836008096 hasConceptScore W1836008096C24586158 @default.
• W1836008096 hasConceptScore W1836008096C2780104201 @default.
• W1836008096 hasConceptScore W1836008096C28859421 @default.
• W1836008096 hasConceptScore W1836008096C54355233 @default.
• W1836008096 hasConceptScore W1836008096C78458016 @default.
• W1836008096 hasConceptScore W1836008096C86803240 @default.
• W1836008096 hasFunder F4320334678 @default.
• W1836008096 hasFunder F4320334704 @default.
• W1836008096 hasIssue "20" @default.
• W1836008096 hasLocation W18360080961 @default.
• W1836008096 hasLocation W18360080962 @default.
• W1836008096 hasOpenAccess W1836008096 @default.
• W1836008096 hasPrimaryLocation W18360080961 @default.
• W1836008096 hasRelatedWork W1970403849 @default.
• W1836008096 hasRelatedWork W1988490558 @default.
• W1836008096 hasRelatedWork W2008266189 @default.
• W1836008096 hasRelatedWork W2020985206 @default.
• W1836008096 hasRelatedWork W2044704400 @default.

• next