FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1836160710> ?p ?o ?g. }

• W1836160710 endingPage "5000" @default.
• W1836160710 startingPage "4996" @default.
• W1836160710 abstract "We report the isolation and characterization of a Neurospora crassa glutamine synthetase (GS) mutant altered in one of the two polypeptides (GS alpha) of this enzyme. We used the gln-1bR8 mutant strain that synthesizes only the GS alpha monomer and lacks the GS beta monomer and selected for growth in minimal medium in the presence of alpha-methyl-DL-methionine-SR-sulfoximine (alpha-me-MSO), an inhibitor of GS activity. The GS activity of the gln-1bR8;alpha-me-MSOR strain drastically reduced its transferase activity and only slightly reduced its synthetase activity, and it was resistant to inhibition by alpha-me-MSO and L-methionine-DL-sulfoximine. The mutation that overcame the inhibitory effect of alpha-me-MSO also altered the antigenic, kinetic, and physical properties of GS alpha. The low GS activity of the alpha-me-MSO-resistant strain was compensated for by a higher glutamate/glutamine ratio and a lower glutamate synthase activity, allowing this strain to grow as well as the parental strain. The mutation that conferred resistance to alpha-me-MSO was not linked to the gln-1bR8 mutation, providing direct evidence of the existence of two genes involved with the structure of the two polypeptides of N. crassa GS." @default.
• W1836160710 created "2016-06-24" @default.
• W1836160710 creator A5003496544 @default.
• W1836160710 creator A5064719496 @default.
• W1836160710 creator A5070290517 @default.
• W1836160710 date "1990-09-01" @default.
• W1836160710 modified "2023-10-03" @default.
• W1836160710 title "Isolation and characterization of a Neurospora crassa mutant altered in the alpha polypeptide of glutamine synthetase" @default.
• W1836160710 cites W111513031 @default.
• W1836160710 cites W141026042 @default.
• W1836160710 cites W1505835356 @default.
• W1836160710 cites W1509276235 @default.
• W1836160710 cites W1542074309 @default.
• W1836160710 cites W1543015280 @default.
• W1836160710 cites W1554200715 @default.
• W1836160710 cites W1576478358 @default.
• W1836160710 cites W1676809070 @default.
• W1836160710 cites W1775749144 @default.
• W1836160710 cites W1797825948 @default.
• W1836160710 cites W1801872377 @default.
• W1836160710 cites W1820387122 @default.
• W1836160710 cites W1897953275 @default.
• W1836160710 cites W2025586394 @default.
• W1836160710 cites W2103967715 @default.
• W1836160710 cites W2132887159 @default.
• W1836160710 cites W2138883839 @default.
• W1836160710 cites W2144813436 @default.
• W1836160710 cites W998956804 @default.
• W1836160710 doi "https://doi.org/10.1128/jb.172.9.4996-5000.1990" @default.
• W1836160710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/213155" @default.
• W1836160710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1975579" @default.
• W1836160710 hasPublicationYear "1990" @default.
• W1836160710 type Work @default.
• W1836160710 sameAs 1836160710 @default.
• W1836160710 citedByCount "13" @default.
• W1836160710 countsByYear W18361607102020 @default.
• W1836160710 crossrefType "journal-article" @default.
• W1836160710 hasAuthorship W1836160710A5003496544 @default.
• W1836160710 hasAuthorship W1836160710A5064719496 @default.
• W1836160710 hasAuthorship W1836160710A5070290517 @default.
• W1836160710 hasBestOaLocation W18361607101 @default.
• W1836160710 hasConcept C104317684 @default.
• W1836160710 hasConcept C105702510 @default.
• W1836160710 hasConcept C143065580 @default.
• W1836160710 hasConcept C153911025 @default.
• W1836160710 hasConcept C159110408 @default.
• W1836160710 hasConcept C181199279 @default.
• W1836160710 hasConcept C2775944032 @default.
• W1836160710 hasConcept C2776739539 @default.
• W1836160710 hasConcept C2776769606 @default.
• W1836160710 hasConcept C2777251434 @default.
• W1836160710 hasConcept C2778022156 @default.
• W1836160710 hasConcept C2779289688 @default.
• W1836160710 hasConcept C2779349466 @default.
• W1836160710 hasConcept C2780912031 @default.
• W1836160710 hasConcept C49453240 @default.
• W1836160710 hasConcept C515207424 @default.
• W1836160710 hasConcept C55493867 @default.
• W1836160710 hasConcept C64943373 @default.
• W1836160710 hasConcept C71924100 @default.
• W1836160710 hasConcept C86803240 @default.
• W1836160710 hasConceptScore W1836160710C104317684 @default.
• W1836160710 hasConceptScore W1836160710C105702510 @default.
• W1836160710 hasConceptScore W1836160710C143065580 @default.
• W1836160710 hasConceptScore W1836160710C153911025 @default.
• W1836160710 hasConceptScore W1836160710C159110408 @default.
• W1836160710 hasConceptScore W1836160710C181199279 @default.
• W1836160710 hasConceptScore W1836160710C2775944032 @default.
• W1836160710 hasConceptScore W1836160710C2776739539 @default.
• W1836160710 hasConceptScore W1836160710C2776769606 @default.
• W1836160710 hasConceptScore W1836160710C2777251434 @default.
• W1836160710 hasConceptScore W1836160710C2778022156 @default.
• W1836160710 hasConceptScore W1836160710C2779289688 @default.
• W1836160710 hasConceptScore W1836160710C2779349466 @default.
• W1836160710 hasConceptScore W1836160710C2780912031 @default.
• W1836160710 hasConceptScore W1836160710C49453240 @default.
• W1836160710 hasConceptScore W1836160710C515207424 @default.
• W1836160710 hasConceptScore W1836160710C55493867 @default.
• W1836160710 hasConceptScore W1836160710C64943373 @default.
• W1836160710 hasConceptScore W1836160710C71924100 @default.
• W1836160710 hasConceptScore W1836160710C86803240 @default.
• W1836160710 hasIssue "9" @default.
• W1836160710 hasLocation W18361607101 @default.
• W1836160710 hasLocation W18361607102 @default.
• W1836160710 hasLocation W18361607103 @default.
• W1836160710 hasLocation W18361607104 @default.
• W1836160710 hasOpenAccess W1836160710 @default.
• W1836160710 hasPrimaryLocation W18361607101 @default.
• W1836160710 hasRelatedWork W111279495 @default.
• W1836160710 hasRelatedWork W1493143551 @default.
• W1836160710 hasRelatedWork W1554200715 @default.
• W1836160710 hasRelatedWork W1569288284 @default.
• W1836160710 hasRelatedWork W1982383123 @default.
• W1836160710 hasRelatedWork W2109551613 @default.
• W1836160710 hasRelatedWork W2109987469 @default.
• W1836160710 hasRelatedWork W2133061161 @default.
• W1836160710 hasRelatedWork W2138736194 @default.
• W1836160710 hasRelatedWork W2144813436 @default.

• next