FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1836264777> ?p ?o ?g. }

• W1836264777 endingPage "1130" @default.
• W1836264777 startingPage "1121" @default.
• W1836264777 abstract "Illegal 'ecstasy' tablets frequently contain 3,4-methylenedioxymethamphetamine (MDMA)-like compounds of unknown pharmacological activity. Since monoamine transporters are one of the primary targets of MDMA action in the brain, a number of MDMA analogues have been tested for their ability to inhibit [3H]noradrenaline uptake into rat PC12 cells expressing the noradrenaline transporter (NET) and [3H]5-HT uptake into HEK293 cells stably transfected with the 5-HT transporter (SERT).Concentration-response curves for the following compounds at both NET and SERT were determined under saturating substrate conditions: 4-hydroxy-3-methoxyamphetamine (HMA), 4-hydroxy-3-methoxymethamphetamine (HMMA), 3,4-methylenedioxy-N-hydroxyamphetamine (MDOH), 2,5-dimethoxy-4-bromophenylethylamine (2CB), 3,4-dimethoxymethamphetamine (DMMA), 3,4-methylenedioxyphenyl-2-butanamine (BDB), 3,4-methylenedioxyphenyl-N-methyl-2-butanamine (MBDB) and 2,3-methylenedioxymethamphetamine (2,3-MDMA).2,3-MDMA was significantly less potent than MDMA at SERT, but equipotent with MDMA at NET. 2CB and BDB were both significantly less potent than MDMA at NET, but equipotent with MDMA at SERT. MBDB, DMMA, MDOH and the MDMA metabolites HMA and HMMA, were all significantly less potent than MDMA at both NET and SERT.This study provides an important insight into the structural requirements of MDMA analogue affinity at both NET and SERT. It is anticipated that these results will facilitate understanding of the likely pharmacological actions of structural analogues of MDMA." @default.
• W1836264777 created "2016-06-24" @default.
• W1836264777 creator A5019308684 @default.
• W1836264777 creator A5021761166 @default.
• W1836264777 creator A5022573604 @default.
• W1836264777 creator A5039245553 @default.
• W1836264777 creator A5074446280 @default.
• W1836264777 creator A5086761554 @default.
• W1836264777 date "2007-12-01" @default.
• W1836264777 modified "2023-10-17" @default.
• W1836264777 title "Comparative potencies of 3,4-methylenedioxymethamphetamine (MDMA) analogues as inhibitors of [³ H]noradrenaline and [³ H]5-HT transport in mammalian cell lines" @default.
• W1836264777 cites W119419419 @default.
• W1836264777 cites W1581194755 @default.
• W1836264777 cites W1931344041 @default.
• W1836264777 cites W1968958292 @default.
• W1836264777 cites W1970587959 @default.
• W1836264777 cites W1985825181 @default.
• W1836264777 cites W1988022129 @default.
• W1836264777 cites W1988670123 @default.
• W1836264777 cites W2007549333 @default.
• W1836264777 cites W2008489493 @default.
• W1836264777 cites W2011370500 @default.
• W1836264777 cites W2011428797 @default.
• W1836264777 cites W2019703023 @default.
• W1836264777 cites W2021015465 @default.
• W1836264777 cites W2031723027 @default.
• W1836264777 cites W2031853052 @default.
• W1836264777 cites W2039498667 @default.
• W1836264777 cites W2041645298 @default.
• W1836264777 cites W2045198740 @default.
• W1836264777 cites W2052176599 @default.
• W1836264777 cites W2056758002 @default.
• W1836264777 cites W2059740952 @default.
• W1836264777 cites W2060809795 @default.
• W1836264777 cites W2061993323 @default.
• W1836264777 cites W2063941388 @default.
• W1836264777 cites W2073415205 @default.
• W1836264777 cites W2085243884 @default.
• W1836264777 cites W2087288531 @default.
• W1836264777 cites W2087542866 @default.
• W1836264777 cites W2090563027 @default.
• W1836264777 cites W2092419524 @default.
• W1836264777 cites W2093708977 @default.
• W1836264777 cites W2093897431 @default.
• W1836264777 cites W2099726177 @default.
• W1836264777 cites W2100718942 @default.
• W1836264777 cites W2102394650 @default.
• W1836264777 cites W2103990773 @default.
• W1836264777 cites W2108827491 @default.
• W1836264777 cites W2111112265 @default.
• W1836264777 cites W2118909127 @default.
• W1836264777 cites W2128951033 @default.
• W1836264777 cites W2132011757 @default.
• W1836264777 cites W2137292290 @default.
• W1836264777 cites W2140062345 @default.
• W1836264777 cites W2144854315 @default.
• W1836264777 cites W2145904740 @default.
• W1836264777 cites W2146337412 @default.
• W1836264777 cites W2151385468 @default.
• W1836264777 cites W2152201062 @default.
• W1836264777 cites W2152949771 @default.
• W1836264777 cites W2153184269 @default.
• W1836264777 cites W2161232429 @default.
• W1836264777 cites W2340043466 @default.
• W1836264777 cites W2410035274 @default.
• W1836264777 cites W2411626280 @default.
• W1836264777 cites W2425237474 @default.
• W1836264777 cites W4246091758 @default.
• W1836264777 doi "https://doi.org/10.1038/sj.bjp.0707473" @default.
• W1836264777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2095113" @default.
• W1836264777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17891159" @default.
• W1836264777 hasPublicationYear "2007" @default.
• W1836264777 type Work @default.
• W1836264777 sameAs 1836264777 @default.
• W1836264777 citedByCount "29" @default.
• W1836264777 countsByYear W18362647772012 @default.
• W1836264777 countsByYear W18362647772013 @default.
• W1836264777 countsByYear W18362647772014 @default.
• W1836264777 countsByYear W18362647772015 @default.
• W1836264777 countsByYear W18362647772016 @default.
• W1836264777 countsByYear W18362647772018 @default.
• W1836264777 countsByYear W18362647772019 @default.
• W1836264777 countsByYear W18362647772020 @default.
• W1836264777 countsByYear W18362647772021 @default.
• W1836264777 countsByYear W18362647772022 @default.
• W1836264777 countsByYear W18362647772023 @default.
• W1836264777 crossrefType "journal-article" @default.
• W1836264777 hasAuthorship W1836264777A5019308684 @default.
• W1836264777 hasAuthorship W1836264777A5021761166 @default.
• W1836264777 hasAuthorship W1836264777A5022573604 @default.
• W1836264777 hasAuthorship W1836264777A5039245553 @default.
• W1836264777 hasAuthorship W1836264777A5074446280 @default.
• W1836264777 hasAuthorship W1836264777A5086761554 @default.
• W1836264777 hasBestOaLocation W18362647771 @default.
• W1836264777 hasConcept C118552586 @default.
• W1836264777 hasConcept C124315065 @default.
• W1836264777 hasConcept C15744967 @default.
• W1836264777 hasConcept C170493617 @default.

• next