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- W1836340893 abstract "The occurrence of anti-beta-2-microglobulin (β2m) lymphocytotoxic antibodies was investigated in 81 sera obtained from 63 patients with systemic lupus erythematosus (SLE). β2m-binding activity, measured by precipitation of radiolabeled β2m in polyethylene glycol, was found significantly higher in SLE than in control sera. Chromatography of SLE sera on polyacrylamideagarose gel AcA 3/4 showed that most of the β2m-binding activity was recovered in the IgG peak. This activity could be adsorbed on staphylococcal protein A-Sepharose immunosorbent. Complement-dependent lymphocytotoxicity was detected at 15°C in 32 SLE sera, of which 19 could be inhibited by addition of 1 ng β2m. A strong association was found between lymphocytotoxicity inhibition by β2m and the presence of β2m-binding material, suggesting that both assays detected β2m autoantibodies. The presence of β2m antibodies was not dependent on the age or sex of the patients, was not correlated with titers of antinuclear antibodies or rheumatoid factors, and was weakly associated with Clq-binding activity. Inhibition experiments indicated that the amount of β2m required to inhibit lymphocytotoxicity or 125I-β2m binding by SLE sera was much higher than that sufficient to inhibit binding by heterologous sera, suggesting that SLE autoantibodies were of low avidity and might be directed against the β2m determinant(s) accessible in the HLA-β2m complex and at the cell surface." @default.
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- W1836340893 date "1979-02-01" @default.
- W1836340893 modified "2023-10-16" @default.
- W1836340893 title "Anti-beta2-microglobulin lymphocytotoxic autoantibodies in systemic lupus erythematosus." @default.
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