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- W183634556 abstract "Pharmacoresistance in epilepsy has received considerable attention in recent years, and several plausible hypotheses have been proposed. Of these, the so-called transporter hypothesis is the most extensively researched and documented. This hypothesis assumes that refractory epilepsy is associated with a localized overexpression of drug transporter proteins such as P-glycoprotein (Pgp) in the epileptic focus region, which actively extrudes antiepileptic drugs (AEDs) from their intended site of action. However, although this hypothesis has biological plausibility, there is no clinical evidence to support the assertion that AEDs are sufficiently strong substrates for transporter-mediated extrusion from the brain. The use of modern brain imaging techniques to determine Pgp function in patients with refractory epilepsy has started only recently, and these techniques may finally determine whether increased expression and function of Pgp or other efflux transporters are involved in AED resistance." @default.
- W183634556 created "2016-06-24" @default.
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- W183634556 date "2009-01-01" @default.
- W183634556 modified "2023-09-25" @default.
- W183634556 title "PHARMACORESISTANCE | Brain Imaging of P-glycoprotein Function in Drug-Resistant Epilepsy" @default.
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- W183634556 doi "https://doi.org/10.1016/b978-012373961-2.00239-3" @default.
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