Matches in SemOpenAlex for { <https://semopenalex.org/work/W1836377684> ?p ?o ?g. }
- W1836377684 abstract "Although pain is a common symptom of various diseases and disorders, its contribution to disease pathogenesis is not well understood. Here we show using murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), that pain induces EAE relapse. Mechanistic analysis showed that pain induction activates a sensory-sympathetic signal followed by a chemokine-mediated accumulation of MHC class II+CD11b+ cells that showed antigen-presentation activity at specific ventral vessels in the fifth lumbar cord of EAE-recovered mice. Following this accumulation, various immune cells including pathogenic CD4+ T cells recruited in the spinal cord in a manner dependent on a local chemokine inducer in endothelial cells, resulting in EAE relapse. Our results demonstrate that a pain-mediated neural signal can be transformed into an inflammation reaction at specific vessels to induce disease relapse, thus making this signal a potential therapeutic target." @default.
- W1836377684 created "2016-06-24" @default.
- W1836377684 creator A5004681173 @default.
- W1836377684 creator A5009690227 @default.
- W1836377684 creator A5015827331 @default.
- W1836377684 creator A5020510395 @default.
- W1836377684 creator A5029900766 @default.
- W1836377684 creator A5044052066 @default.
- W1836377684 creator A5047385814 @default.
- W1836377684 creator A5056051274 @default.
- W1836377684 creator A5057781163 @default.
- W1836377684 creator A5060322837 @default.
- W1836377684 creator A5063264098 @default.
- W1836377684 creator A5063407770 @default.
- W1836377684 creator A5063756074 @default.
- W1836377684 creator A5064303731 @default.
- W1836377684 creator A5068093589 @default.
- W1836377684 creator A5069151709 @default.
- W1836377684 creator A5076608744 @default.
- W1836377684 creator A5080691742 @default.
- W1836377684 creator A5085117517 @default.
- W1836377684 creator A5086994208 @default.
- W1836377684 creator A5090129110 @default.
- W1836377684 date "2015-08-11" @default.
- W1836377684 modified "2023-10-14" @default.
- W1836377684 title "A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model" @default.
- W1836377684 cites W1553081674 @default.
- W1836377684 cites W1840184482 @default.
- W1836377684 cites W1966351672 @default.
- W1836377684 cites W1967477376 @default.
- W1836377684 cites W1974188582 @default.
- W1836377684 cites W1979511676 @default.
- W1836377684 cites W1982134608 @default.
- W1836377684 cites W1982931411 @default.
- W1836377684 cites W1983180002 @default.
- W1836377684 cites W1987573662 @default.
- W1836377684 cites W1989588757 @default.
- W1836377684 cites W1995920809 @default.
- W1836377684 cites W1996303646 @default.
- W1836377684 cites W1996545459 @default.
- W1836377684 cites W2002958204 @default.
- W1836377684 cites W2012129281 @default.
- W1836377684 cites W2016155475 @default.
- W1836377684 cites W2019466258 @default.
- W1836377684 cites W2020279774 @default.
- W1836377684 cites W2023771303 @default.
- W1836377684 cites W2024127570 @default.
- W1836377684 cites W2030498057 @default.
- W1836377684 cites W2039544748 @default.
- W1836377684 cites W2040547343 @default.
- W1836377684 cites W2041554374 @default.
- W1836377684 cites W2048134457 @default.
- W1836377684 cites W2049222272 @default.
- W1836377684 cites W2053687013 @default.
- W1836377684 cites W2061378788 @default.
- W1836377684 cites W2080058754 @default.
- W1836377684 cites W2083570580 @default.
- W1836377684 cites W2087454739 @default.
- W1836377684 cites W2091601326 @default.
- W1836377684 cites W2099359816 @default.
- W1836377684 cites W2101899879 @default.
- W1836377684 cites W2103447016 @default.
- W1836377684 cites W2105062572 @default.
- W1836377684 cites W2105367260 @default.
- W1836377684 cites W2107906835 @default.
- W1836377684 cites W2110150351 @default.
- W1836377684 cites W2118730986 @default.
- W1836377684 cites W2135200424 @default.
- W1836377684 cites W2135839986 @default.
- W1836377684 cites W2138398976 @default.
- W1836377684 cites W2144215670 @default.
- W1836377684 cites W2144442541 @default.
- W1836377684 cites W2147173525 @default.
- W1836377684 cites W2148097152 @default.
- W1836377684 cites W2153642626 @default.
- W1836377684 cites W2162360300 @default.
- W1836377684 cites W2163225965 @default.
- W1836377684 cites W2167941289 @default.
- W1836377684 cites W2170173133 @default.
- W1836377684 cites W2171255545 @default.
- W1836377684 doi "https://doi.org/10.7554/elife.08733" @default.
- W1836377684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4530187" @default.
- W1836377684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26193120" @default.
- W1836377684 hasPublicationYear "2015" @default.
- W1836377684 type Work @default.
- W1836377684 sameAs 1836377684 @default.
- W1836377684 citedByCount "53" @default.
- W1836377684 countsByYear W18363776842015 @default.
- W1836377684 countsByYear W18363776842016 @default.
- W1836377684 countsByYear W18363776842017 @default.
- W1836377684 countsByYear W18363776842018 @default.
- W1836377684 countsByYear W18363776842019 @default.
- W1836377684 countsByYear W18363776842020 @default.
- W1836377684 countsByYear W18363776842021 @default.
- W1836377684 countsByYear W18363776842022 @default.
- W1836377684 countsByYear W18363776842023 @default.
- W1836377684 crossrefType "journal-article" @default.
- W1836377684 hasAuthorship W1836377684A5004681173 @default.
- W1836377684 hasAuthorship W1836377684A5009690227 @default.
- W1836377684 hasAuthorship W1836377684A5015827331 @default.