FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1836411230> ?p ?o ?g. }

• W1836411230 endingPage "7503" @default.
• W1836411230 startingPage "7496" @default.
• W1836411230 abstract "Microglial ingestion of the amyloid beta-peptide (Abeta) has been viewed as a therapeutic target in Alzheimer's disease, in that approaches that enhance clearance of Abeta relative to its production are predicted to result in decreased senile plaque formation, a proposed contributor to neuropathology. In vitro, scavenger receptors mediate ingestion of fibrillar Abeta (fAbeta) by microglia. However, the finding that cerebral amyloid deposition in a transgenic mouse model of Alzheimer's disease was diminished by inoculation with synthetic Abeta has suggested a possible therapeutic role for anti-Abeta Ab-mediated phagocytosis. Microglia also express C1qR(P), a receptor for complement protein C1q, ligation of which in vitro enhances phagocytosis of immune complexes formed with IgG levels below that required for optimal FcR-mediated phagocytosis. The data presented here demonstrate FcR-dependent ingestion of Abeta-anti-Abeta complexes (IgG-fAbeta) by microglia that is a function of the amount of Ab used to form immune complexes. In addition, C1q incorporated into IgG-fAbeta enhanced microglial uptake of these complexes when they contained suboptimal levels of anti-Abeta Ab. Mannose binding lectin and lung surfactant protein A, other ligands of C1qR(P), also enhanced ingestion of suboptimally opsonized IgG-fAbeta, whereas control proteins did not. Our data suggest that C1qR(P)-mediated events may promote efficient ingestion of Abeta at low Ab titers, and this may be beneficial in paradigms that seek to clear amyloid via FcR-mediated mechanisms by minimizing the potential for destructive Ab-induced complement-mediated processes." @default.
• W1836411230 created "2016-06-24" @default.
• W1836411230 creator A5034468688 @default.
• W1836411230 creator A5035454691 @default.
• W1836411230 creator A5055345868 @default.
• W1836411230 creator A5058685797 @default.
• W1836411230 creator A5062218007 @default.
• W1836411230 creator A5079367953 @default.
• W1836411230 date "2001-06-15" @default.
• W1836411230 modified "2023-10-12" @default.
• W1836411230 title "Antibody-Mediated Phagocytosis of the Amyloid β-Peptide in Microglia Is Differentially Modulated by C1q" @default.
• W1836411230 cites W1488124756 @default.
• W1836411230 cites W1549447146 @default.
• W1836411230 cites W1552769647 @default.
• W1836411230 cites W1560807874 @default.
• W1836411230 cites W1567490604 @default.
• W1836411230 cites W1568481877 @default.
• W1836411230 cites W1569129572 @default.
• W1836411230 cites W1570456520 @default.
• W1836411230 cites W1619222389 @default.
• W1836411230 cites W1693283493 @default.
• W1836411230 cites W1966510897 @default.
• W1836411230 cites W1971313633 @default.
• W1836411230 cites W1971349333 @default.
• W1836411230 cites W1973453969 @default.
• W1836411230 cites W1976038427 @default.
• W1836411230 cites W1977627900 @default.
• W1836411230 cites W1989473075 @default.
• W1836411230 cites W1999059156 @default.
• W1836411230 cites W1999184788 @default.
• W1836411230 cites W2009488396 @default.
• W1836411230 cites W2033102468 @default.
• W1836411230 cites W2039716280 @default.
• W1836411230 cites W2041685010 @default.
• W1836411230 cites W2042538218 @default.
• W1836411230 cites W2048846362 @default.
• W1836411230 cites W2049414096 @default.
• W1836411230 cites W2051583618 @default.
• W1836411230 cites W2057775179 @default.
• W1836411230 cites W2066304306 @default.
• W1836411230 cites W2069807839 @default.
• W1836411230 cites W2076841009 @default.
• W1836411230 cites W2083758179 @default.
• W1836411230 cites W2085056370 @default.
• W1836411230 cites W2087161646 @default.
• W1836411230 cites W2087317511 @default.
• W1836411230 cites W2092411904 @default.
• W1836411230 cites W2108676263 @default.
• W1836411230 cites W2115296748 @default.
• W1836411230 cites W2116375947 @default.
• W1836411230 cites W2116784956 @default.
• W1836411230 cites W2130144581 @default.
• W1836411230 cites W2163893226 @default.
• W1836411230 cites W2171925564 @default.
• W1836411230 cites W2284322088 @default.
• W1836411230 cites W2497993295 @default.
• W1836411230 doi "https://doi.org/10.4049/jimmunol.166.12.7496" @default.
• W1836411230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11390503" @default.
• W1836411230 hasPublicationYear "2001" @default.
• W1836411230 type Work @default.
• W1836411230 sameAs 1836411230 @default.
• W1836411230 citedByCount "97" @default.
• W1836411230 countsByYear W18364112302012 @default.
• W1836411230 countsByYear W18364112302013 @default.
• W1836411230 countsByYear W18364112302014 @default.
• W1836411230 countsByYear W18364112302015 @default.
• W1836411230 countsByYear W18364112302016 @default.
• W1836411230 countsByYear W18364112302017 @default.
• W1836411230 countsByYear W18364112302018 @default.
• W1836411230 countsByYear W18364112302019 @default.
• W1836411230 countsByYear W18364112302020 @default.
• W1836411230 countsByYear W18364112302021 @default.
• W1836411230 countsByYear W18364112302022 @default.
• W1836411230 countsByYear W18364112302023 @default.
• W1836411230 crossrefType "journal-article" @default.
• W1836411230 hasAuthorship W1836411230A5034468688 @default.
• W1836411230 hasAuthorship W1836411230A5035454691 @default.
• W1836411230 hasAuthorship W1836411230A5055345868 @default.
• W1836411230 hasAuthorship W1836411230A5058685797 @default.
• W1836411230 hasAuthorship W1836411230A5062218007 @default.
• W1836411230 hasAuthorship W1836411230A5079367953 @default.
• W1836411230 hasBestOaLocation W18364112301 @default.
• W1836411230 hasConcept C111684460 @default.
• W1836411230 hasConcept C126322002 @default.
• W1836411230 hasConcept C133493029 @default.
• W1836411230 hasConcept C136449434 @default.
• W1836411230 hasConcept C160448771 @default.
• W1836411230 hasConcept C170493617 @default.
• W1836411230 hasConcept C175773311 @default.
• W1836411230 hasConcept C177907266 @default.
• W1836411230 hasConcept C185592680 @default.
• W1836411230 hasConcept C203014093 @default.
• W1836411230 hasConcept C2776914184 @default.
• W1836411230 hasConcept C2777633098 @default.
• W1836411230 hasConcept C2778163477 @default.
• W1836411230 hasConcept C2779134260 @default.
• W1836411230 hasConcept C2779830541 @default.
• W1836411230 hasConcept C2780072125 @default.

• next