FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1836616976> ?p ?o ?g. }

• W1836616976 endingPage "2935" @default.
• W1836616976 startingPage "2927" @default.
• W1836616976 abstract "Chronic kidney disease (CKD) is characterized by vascular remodeling and the retention of uremic toxins, several of which are independently associated with the high cardiovascular mortality rate in CKD patients. Whether the association between these uremic toxins and cardiovascular mortality is due to induction of vascular dysfunction and resulting vascular remodeling remains to be determined. This study evaluates the effects of para-cresyl sulfate (PCS), a newly identified uremic toxin, on vascular function and remodeling. PCS acutely induced oxidative stress in both endothelial and vascular smooth muscle cells, with a maximal effect at 0.15 mM, corresponding to the mean “uremic” concentration found in dialysis patients. PCS significantly increased within 30 min phenylephrine-induced contraction of mouse thoracic aorta, through direct activation of rho-kinase, independently of oxidative stress induction, as demonstrated by the capacity of rho-kinase inhibitor Y-27632 to abolish this effect. After exposure of the aorta to PCS for 48 h, we observed inward eutrophic remodeling, a hallmark of uremic vasculopathy characterized by a reduction of the area of both lumen and media, with unchanged media/lumen ratio. In conclusion, elevated PCS concentrations such as those observed in CKD patients, by promoting both vascular dysfunction and vascular remodeling, may contribute to the development of hypertension and to cardiovascular mortality in CKD. J. Cell. Physiol. 230: 2927–2935, 2015. © 2015 Wiley Periodicals, Inc." @default.
• W1836616976 created "2016-06-24" @default.
• W1836616976 creator A5000798304 @default.
• W1836616976 creator A5035072931 @default.
• W1836616976 creator A5036728599 @default.
• W1836616976 creator A5063300681 @default.
• W1836616976 creator A5068979940 @default.
• W1836616976 creator A5069187611 @default.
• W1836616976 creator A5072535430 @default.
• W1836616976 creator A5076711449 @default.
• W1836616976 creator A5078659957 @default.
• W1836616976 date "2015-08-24" @default.
• W1836616976 modified "2023-09-25" @default.
• W1836616976 title "Para-cresyl sulfate acutely impairs vascular reactivity and induces vascular remodeling" @default.
• W1836616976 cites W1597787921 @default.
• W1836616976 cites W1963620624 @default.
• W1836616976 cites W1964236959 @default.
• W1836616976 cites W1966082505 @default.
• W1836616976 cites W1974141237 @default.
• W1836616976 cites W1975266676 @default.
• W1836616976 cites W1975554421 @default.
• W1836616976 cites W1975976477 @default.
• W1836616976 cites W1979051888 @default.
• W1836616976 cites W1994800928 @default.
• W1836616976 cites W2000653364 @default.
• W1836616976 cites W2002373438 @default.
• W1836616976 cites W2010283901 @default.
• W1836616976 cites W2014054217 @default.
• W1836616976 cites W2020458548 @default.
• W1836616976 cites W2020899877 @default.
• W1836616976 cites W2028522223 @default.
• W1836616976 cites W2029082818 @default.
• W1836616976 cites W2032295238 @default.
• W1836616976 cites W2033739825 @default.
• W1836616976 cites W2038233030 @default.
• W1836616976 cites W2040282619 @default.
• W1836616976 cites W2043051762 @default.
• W1836616976 cites W2053272981 @default.
• W1836616976 cites W2057788590 @default.
• W1836616976 cites W2058597788 @default.
• W1836616976 cites W2064722489 @default.
• W1836616976 cites W2069887689 @default.
• W1836616976 cites W2080227358 @default.
• W1836616976 cites W2096129774 @default.
• W1836616976 cites W2100588235 @default.
• W1836616976 cites W2100777277 @default.
• W1836616976 cites W2103772533 @default.
• W1836616976 cites W2110719623 @default.
• W1836616976 cites W2110953677 @default.
• W1836616976 cites W2114997404 @default.
• W1836616976 cites W2121378400 @default.
• W1836616976 cites W2123391323 @default.
• W1836616976 cites W2130004811 @default.
• W1836616976 cites W2133057324 @default.
• W1836616976 cites W2137037580 @default.
• W1836616976 cites W2152088948 @default.
• W1836616976 cites W2155897723 @default.
• W1836616976 cites W2161467739 @default.
• W1836616976 cites W2161583498 @default.
• W1836616976 cites W2164334517 @default.
• W1836616976 cites W2168368219 @default.
• W1836616976 cites W2169882884 @default.
• W1836616976 cites W2171365654 @default.
• W1836616976 doi "https://doi.org/10.1002/jcp.25018" @default.
• W1836616976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25899466" @default.
• W1836616976 hasPublicationYear "2015" @default.
• W1836616976 type Work @default.
• W1836616976 sameAs 1836616976 @default.
• W1836616976 citedByCount "54" @default.
• W1836616976 countsByYear W18366169762016 @default.
• W1836616976 countsByYear W18366169762017 @default.
• W1836616976 countsByYear W18366169762018 @default.
• W1836616976 countsByYear W18366169762019 @default.
• W1836616976 countsByYear W18366169762020 @default.
• W1836616976 countsByYear W18366169762021 @default.
• W1836616976 countsByYear W18366169762022 @default.
• W1836616976 countsByYear W18366169762023 @default.
• W1836616976 crossrefType "journal-article" @default.
• W1836616976 hasAuthorship W1836616976A5000798304 @default.
• W1836616976 hasAuthorship W1836616976A5035072931 @default.
• W1836616976 hasAuthorship W1836616976A5036728599 @default.
• W1836616976 hasAuthorship W1836616976A5063300681 @default.
• W1836616976 hasAuthorship W1836616976A5068979940 @default.
• W1836616976 hasAuthorship W1836616976A5069187611 @default.
• W1836616976 hasAuthorship W1836616976A5072535430 @default.
• W1836616976 hasAuthorship W1836616976A5076711449 @default.
• W1836616976 hasAuthorship W1836616976A5078659957 @default.
• W1836616976 hasConcept C120770815 @default.
• W1836616976 hasConcept C126322002 @default.
• W1836616976 hasConcept C134018914 @default.
• W1836616976 hasConcept C164705383 @default.
• W1836616976 hasConcept C2776151105 @default.
• W1836616976 hasConcept C2777466421 @default.
• W1836616976 hasConcept C2778653478 @default.
• W1836616976 hasConcept C2779395532 @default.
• W1836616976 hasConcept C2779980429 @default.
• W1836616976 hasConcept C2992686903 @default.
• W1836616976 hasConcept C71924100 @default.

• next