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- W1836645 abstract "Guanine nucleotide-binding (G) proteins play an essential role in the signal transduction pathway between a wide range of membrane receptors and ion channels. The mechanisms by which G proteins regulate ion channels are indirect through cytoplasmic agents. Results obtained from combined approaches of biochemistry, molecular biology, and single-channel recordings have shown that G proteins act on ion channels in a direct or at least membrane delimited manner. This chapter presents the evidence that ion channels are regulated not only by ligand and voltage but also directly by G proteins. It is possible that various G proteins interact with a single effector and have little specificity in effector regulation. Isolated patch experiments bypass interactions between receptors and G proteins, thus, allowing assessment of the direct effects of G proteins on ion channels. The chapter also discusses that studies on the coupling processes between receptors and G proteins in intact cells need to be performed to differentiate functional specificity in the physiological cellular responses to external signals." @default.
- W1836645 created "2016-06-24" @default.
- W1836645 creator A5091383588 @default.
- W1836645 date "1995-01-01" @default.
- W1836645 modified "2023-09-26" @default.
- W1836645 title "Ion Channels That Are Directly Regulated by G Proteins" @default.
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- W1836645 doi "https://doi.org/10.1016/b978-0-12-656970-4.50033-6" @default.
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