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• W1836657330 abstract "E-cadherin, a cell surface protein involved in cell adhesion, is present in normal breast epithelium, benign breast lesions, and in breast carcinoma. Alterations in the gene CDH1 on chromosome 16q22 are associated with changes in E-cadherin protein expression and function. Inactivation of E-cadherin in lobular carcinomas and certain diffuse gastric carcinomas may play a role in the dispersed, discohesive single cell growth patterns seen in these tumors. The molecular signature of mammary lobular carcinomas is the loss of E-cadherin protein expression as evidenced by immunohistochemistry, whereas ductal carcinomas are typically E-cadherin positive.We report on E-cadherin immunostaining patterns in five cases of invasive mammary carcinoma.These were five exceptional instances in which the E-cadherin immunophenotype did not correspond to the apparent histologic classification of the lesion. These cases which are exceedingly rare in our experience are the subject of this report.Findings such as those illustrated in this study occur in virtually all biologic phenomena and they do not invalidate the very high degree of correlation between the expression of E-cadherin and the classification of breast carcinomas as ductal or lobular type on the basis of conventional histologic criteria." @default.
• W1836657330 created "2016-06-24" @default.
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• W1836657330 date "2005-11-14" @default.
• W1836657330 modified "2023-09-26" @default.
• W1836657330 title "Aberrant E-cadherin staining patterns in invasive mammary carcinoma" @default.
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• W1836657330 doi "https://doi.org/10.1186/1477-7819-3-73" @default.
• W1836657330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1308872" @default.
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• W1836657330 hasPublicationYear "2005" @default.
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