Matches in SemOpenAlex for { <https://semopenalex.org/work/W1836689318> ?p ?o ?g. }
- W1836689318 endingPage "10105" @default.
- W1836689318 startingPage "10093" @default.
- W1836689318 abstract "Objective: The aim of this multiple-hospital study was to investigate the prevalence of integrons in multidrug-resistant Acinetobacter baumannii (MDRAB) in Eastern China, and characterize the integron-integrase genes, so as to provide evidence for the management and appropriate antibiotic use of MDRAB infections. Methods: A total of 425 clinical isolates of A. baumannii were collected from 16 tertiary hospitals in 11 cities of four provinces (Fujian, Jiangsu, Zhejiang and Shandong) from January 2009 to June 2012. The susceptibility of A. baumannii isolates to ampicillin/sulbactam, piperacillin/tazobactam, ceftazidime, ceftriaxone, cefepime, aztreonam, meropenem, amikacin, gentamicin, tobramycin, ciprofloxacin, levofloxacin, sulfamethoxazole/trimenthoprim, minocycline and imipenem was tested, and integrons and their gene cassettes were characterized in these isolates using PCR assay. In addition, integron-positive A. baumannii isolates were genotyped using pulsed-field gel electrophoresis (PFGE) assay, and intI1 gene cassette was sequenced. Results: intI1 gene was carried in 69.6% of total A. baumannii isolates, while intI2 and intI3 genes were not detected. The prevalence of resistance to ampicillin/sulbactam, piperacillin/tazobactam, ceftazidime, ceftriaxone, cefepime, aztreonam, imipenem, meropenem, amikacin, gentamicin, tobramycin, ciprofloxacin, levofloxacin and sulfamethoxazole/trimenthoprim was significantly higher in integron-positive A. baumannii isolates than in negative isolates (all p values <0.05), while no significant difference was observed in the prevalence of minocycline resistance (p > 0.05). PFGE assay revealed 27 PFGE genotypes and 4 predominant genotypes, P1, P4, P7 and P19. The PFGE genotype P1 contained 13 extensive-drug resistant and 89 non-extensive-drug resistant A. baumannii isolates, while the genotype P4 contained 34 extensive-drug resistant and 67 non-extensive-drug resistant isolates, appearing a significant antimicrobial resistance pattern (both p values <0.05). Sequencing analysis revealed two gene cassette assays of aacA4-catB8-aadA1 and dfrXII-orfF-aadA2 in MDRAB isolates. Conclusions: The results of this study demonstrate a high prevalence of class 1 integrons in MDRAB in Eastern China, and a greater prevalence of antimicrobial resistance in intI1 gene-positive MDRAB isolates than in negative isolates. Four predominant PFGE genotypes are identified in intI1 gene-positive MDRAB isolates, in which P4 is an epidemic PFGE genotype in Fujian Province, and it has a high proportion of extensive drug resistant A. baumannii. The gene cassette dfrXII-orfF-aadA2 is reported, for the first time, in A. baumannii strains isolated from Fujian Province, Eastern China." @default.
- W1836689318 created "2016-06-24" @default.
- W1836689318 creator A5050562059 @default.
- W1836689318 creator A5056291458 @default.
- W1836689318 creator A5058328956 @default.
- W1836689318 creator A5058589650 @default.
- W1836689318 creator A5064261273 @default.
- W1836689318 creator A5065573082 @default.
- W1836689318 date "2015-08-21" @default.
- W1836689318 modified "2023-09-27" @default.
- W1836689318 title "Prevalence and Characterization of Integrons in Multidrug Resistant Acinetobacter baumannii in Eastern China: A Multiple-Hospital Study" @default.
- W1836689318 cites W144958371 @default.
- W1836689318 cites W1541488278 @default.
- W1836689318 cites W1928512163 @default.
- W1836689318 cites W1950061043 @default.
- W1836689318 cites W1955612312 @default.
- W1836689318 cites W1989702350 @default.
- W1836689318 cites W2003783897 @default.
- W1836689318 cites W2009358848 @default.
- W1836689318 cites W2019577872 @default.
- W1836689318 cites W2022510880 @default.
- W1836689318 cites W2023625688 @default.
- W1836689318 cites W2028789388 @default.
- W1836689318 cites W2045718514 @default.
- W1836689318 cites W2048184911 @default.
- W1836689318 cites W2052130550 @default.
- W1836689318 cites W2052354577 @default.
- W1836689318 cites W2053817052 @default.
- W1836689318 cites W2061885127 @default.
- W1836689318 cites W2064740494 @default.
- W1836689318 cites W2096898012 @default.
- W1836689318 cites W2105489185 @default.
- W1836689318 cites W2108641376 @default.
- W1836689318 cites W2113828015 @default.
- W1836689318 cites W2118328361 @default.
- W1836689318 cites W2126376232 @default.
- W1836689318 cites W2131090898 @default.
- W1836689318 cites W2133692454 @default.
- W1836689318 cites W2138364671 @default.
- W1836689318 cites W2140571398 @default.
- W1836689318 cites W2146049144 @default.
- W1836689318 cites W2153741593 @default.
- W1836689318 cites W2154268169 @default.
- W1836689318 cites W2159435953 @default.
- W1836689318 cites W2162824360 @default.
- W1836689318 cites W2168168394 @default.
- W1836689318 cites W2168647298 @default.
- W1836689318 cites W2170241141 @default.
- W1836689318 cites W4237421950 @default.
- W1836689318 cites W72408332 @default.
- W1836689318 doi "https://doi.org/10.3390/ijerph120810093" @default.
- W1836689318 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4555331" @default.
- W1836689318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26308028" @default.
- W1836689318 hasPublicationYear "2015" @default.
- W1836689318 type Work @default.
- W1836689318 sameAs 1836689318 @default.
- W1836689318 citedByCount "18" @default.
- W1836689318 countsByYear W18366893182015 @default.
- W1836689318 countsByYear W18366893182016 @default.
- W1836689318 countsByYear W18366893182018 @default.
- W1836689318 countsByYear W18366893182019 @default.
- W1836689318 countsByYear W18366893182020 @default.
- W1836689318 countsByYear W18366893182021 @default.
- W1836689318 countsByYear W18366893182022 @default.
- W1836689318 crossrefType "journal-article" @default.
- W1836689318 hasAuthorship W1836689318A5050562059 @default.
- W1836689318 hasAuthorship W1836689318A5056291458 @default.
- W1836689318 hasAuthorship W1836689318A5058328956 @default.
- W1836689318 hasAuthorship W1836689318A5058589650 @default.
- W1836689318 hasAuthorship W1836689318A5064261273 @default.
- W1836689318 hasAuthorship W1836689318A5065573082 @default.
- W1836689318 hasBestOaLocation W18366893181 @default.
- W1836689318 hasConcept C104317684 @default.
- W1836689318 hasConcept C135763542 @default.
- W1836689318 hasConcept C2776021129 @default.
- W1836689318 hasConcept C2776315533 @default.
- W1836689318 hasConcept C2776650774 @default.
- W1836689318 hasConcept C2776968632 @default.
- W1836689318 hasConcept C2777050379 @default.
- W1836689318 hasConcept C2777427914 @default.
- W1836689318 hasConcept C2777637488 @default.
- W1836689318 hasConcept C2778193466 @default.
- W1836689318 hasConcept C2778478555 @default.
- W1836689318 hasConcept C2779375183 @default.
- W1836689318 hasConcept C2779631663 @default.
- W1836689318 hasConcept C2780416669 @default.
- W1836689318 hasConcept C42084846 @default.
- W1836689318 hasConcept C501593827 @default.
- W1836689318 hasConcept C523546767 @default.
- W1836689318 hasConcept C54355233 @default.
- W1836689318 hasConcept C55493867 @default.
- W1836689318 hasConcept C71924100 @default.
- W1836689318 hasConcept C86803240 @default.
- W1836689318 hasConcept C89423630 @default.
- W1836689318 hasConcept C94665300 @default.
- W1836689318 hasConceptScore W1836689318C104317684 @default.
- W1836689318 hasConceptScore W1836689318C135763542 @default.
- W1836689318 hasConceptScore W1836689318C2776021129 @default.