Matches in SemOpenAlex for { <https://semopenalex.org/work/W1836691084> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W1836691084 endingPage "329" @default.
- W1836691084 startingPage "321" @default.
- W1836691084 abstract "Publisher Summary This chapter describes the development of polarized cellular systems coexpressing adenovirus (AdV) with CYP3A4 (Ad3A4), P450 reductase (AdRed), and the MDR1/Pgp transporter. Because the experimental approach may be adapted to study the interplay of multiple enzyme/transporting systems, it may find significant application as a screening tool for the pharmaceutical industry and as a more basic research tool to study the kinetics of intestinal drug bioavailability. The expression system must have robust CYP3A4 activity. Transduction with recombinant adenovirus (AdV) offers several advantages.6 Adenovirus infects most cell types, levels of the recombinant protein can represent 15-20% of total cellular protein, and multiple AdV can be introduced simultaneously. The multidrug resistance gene MDR1 encodes the drug efflux transporter P-glycoprotein (Pgp), and because many drugs that interact with CYP3A are Pgp substrates, this transporter can influence the magnitude of CYP3A induction 1 and CYP3A metabolism. The challenges for the future are to generate model systems in which the dynamic interplay between drug transporting proteins and drug metabolizing enzymes may be explored." @default.
- W1836691084 created "2016-06-24" @default.
- W1836691084 creator A5012663330 @default.
- W1836691084 creator A5073683699 @default.
- W1836691084 date "2002-01-01" @default.
- W1836691084 modified "2023-09-23" @default.
- W1836691084 title "Polarized cell cultures for integrated studies of drug metabolism and transport" @default.
- W1836691084 cites W1521545709 @default.
- W1836691084 cites W1870564186 @default.
- W1836691084 cites W1979732900 @default.
- W1836691084 cites W1993945284 @default.
- W1836691084 cites W2005313857 @default.
- W1836691084 cites W2114804558 @default.
- W1836691084 cites W2136564762 @default.
- W1836691084 cites W323918011 @default.
- W1836691084 cites W53991724 @default.
- W1836691084 doi "https://doi.org/10.1016/s0076-6879(02)57690-4" @default.
- W1836691084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12424922" @default.
- W1836691084 hasPublicationYear "2002" @default.
- W1836691084 type Work @default.
- W1836691084 sameAs 1836691084 @default.
- W1836691084 citedByCount "3" @default.
- W1836691084 countsByYear W18366910842012 @default.
- W1836691084 countsByYear W18366910842021 @default.
- W1836691084 crossrefType "book-chapter" @default.
- W1836691084 hasAuthorship W1836691084A5012663330 @default.
- W1836691084 hasAuthorship W1836691084A5073683699 @default.
- W1836691084 hasConcept C185592680 @default.
- W1836691084 hasConcept C2780035454 @default.
- W1836691084 hasConcept C2991704936 @default.
- W1836691084 hasConcept C55493867 @default.
- W1836691084 hasConcept C62231903 @default.
- W1836691084 hasConcept C86803240 @default.
- W1836691084 hasConcept C89311334 @default.
- W1836691084 hasConcept C95444343 @default.
- W1836691084 hasConcept C98274493 @default.
- W1836691084 hasConceptScore W1836691084C185592680 @default.
- W1836691084 hasConceptScore W1836691084C2780035454 @default.
- W1836691084 hasConceptScore W1836691084C2991704936 @default.
- W1836691084 hasConceptScore W1836691084C55493867 @default.
- W1836691084 hasConceptScore W1836691084C62231903 @default.
- W1836691084 hasConceptScore W1836691084C86803240 @default.
- W1836691084 hasConceptScore W1836691084C89311334 @default.
- W1836691084 hasConceptScore W1836691084C95444343 @default.
- W1836691084 hasConceptScore W1836691084C98274493 @default.
- W1836691084 hasLocation W18366910841 @default.
- W1836691084 hasLocation W18366910842 @default.
- W1836691084 hasOpenAccess W1836691084 @default.
- W1836691084 hasPrimaryLocation W18366910841 @default.
- W1836691084 hasRelatedWork W135333318 @default.
- W1836691084 hasRelatedWork W1522906035 @default.
- W1836691084 hasRelatedWork W1556369711 @default.
- W1836691084 hasRelatedWork W1586567353 @default.
- W1836691084 hasRelatedWork W1971658588 @default.
- W1836691084 hasRelatedWork W2148885238 @default.
- W1836691084 hasRelatedWork W2202336857 @default.
- W1836691084 hasRelatedWork W2800854820 @default.
- W1836691084 hasRelatedWork W4247776486 @default.
- W1836691084 hasRelatedWork W4248543159 @default.
- W1836691084 isParatext "false" @default.
- W1836691084 isRetracted "false" @default.
- W1836691084 magId "1836691084" @default.
- W1836691084 workType "book-chapter" @default.