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- W1836691365 abstract "A38 Background: Several biomarkers have been reported in different types of tumors and associated with prognostic value. The identification and the correlation of these proteins over expressed or reduced with clinical-pathological aspects is a hard work. Exploring our results obtained by using proteomic tools and oral carcinoma, we selected three proteins with supposed differential expression to investigate and to validate possible correlation between clinical, pathological and molecular characteristics. Material and Methods: ninety five Brazilian HNSCC tumors samples have been spotted in duplicate on the same tissue microarray and analyzed by immunohistochemistry. Other thirty cancerous samples and their paired normal counterparts have been studied by immuno blot technique. The pathological and clinical characteristics of all tumors and patients have been done by pathologist and doctor. The research protocol has been approved by Ethical Committee for Human Research. Results: two proteins showed up regulation and other down regulation in tumors. The positive staining for SET showed association with differentiation and hnRNPK proteins were related with survival. For MARK3 protein we observed none or weak staining and this observation has been noted mainly in patients with positive lymph node. Interestingly, hnRNPK protein analysis revealed high nuclear expression in tumor samples and showed dual cytoplasm and nucleus distribution. The cytoplasm has not been associated with poor prognostic. Conclusion: The three proteins studied together can be considered as new prognostic markers in head and neck cancer. Also, our results suggest these proteins as biomarkers of tumor differentiation, aggressiveness and survival. Future investigations about the role of these proteins in HNSCC must be employed and can open new opportunities for therapeutics. Financial support: CNPq, FAPESP, NIH." @default.
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- W1836691365 date "2008-10-01" @default.
- W1836691365 modified "2023-09-24" @default.
- W1836691365 title "Three protein markers in HNSCC: hnRNPK, SET and MARK3" @default.
- W1836691365 hasPublicationYear "2008" @default.
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