FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1836703946> ?p ?o ?g. }

• W1836703946 abstract "Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder arising as a result of the reciprocal translocation between the long arms of chromosomes 9 and 22 (t9;22), leading to the formation of the fusion oncogene  BCR-ABL . BCR-ABL has constitutive tyrosine kinase (TK) activity which is necessary for the transformed phenotype. The introduction at the end of the last century of BCR-ABL TK inhibitors (TKI) has dramatically changed the management of CML however despite their great efficacy, TKI are not curative. Disease persistence in CML patients treated with TKI lies in the insensitivity of the most primitive CML leukaemia stem cell (LSC). CML LSCs are not addicted to BCR-ABL kinase activity but rather rely on other stem cell intrinsic pathways for their survival. The main focus in the CML field is therefore to identify these pathways while also trying to exploit them therapeutically to achieve CML LSC eradication and as a result disease cure. Here we briefly review recent research on the role of the intracellular janus kinase (JAK) 2 in CML LSC survival and proliferation and discuss its putative role as a therapeutic target in CML. We discuss evidence supporting or dismissing a role for JAK2 in CML LSC survival and provide a possible explanation to reconcile the contrasting data published.  We finally outline the future challenges which lie ahead of the CML community in trying to elucidate further the mechanisms of action of JAK2 and to translate into clinical practice the use of JAK2 inhibitors in CML." @default.
• W1836703946 created "2016-06-24" @default.
• W1836703946 creator A5060367154 @default.
• W1836703946 date "2014-11-03" @default.
• W1836703946 modified "2023-09-27" @default.
• W1836703946 title "THE ROLE OF JAK2 INHIBITORS IN THE MANAGEMENT OF CML: CAN WE REST THE CASE?" @default.
• W1836703946 cites W1510546584 @default.
• W1836703946 cites W1964957919 @default.
• W1836703946 cites W1966722003 @default.
• W1836703946 cites W1980568348 @default.
• W1836703946 cites W1998593414 @default.
• W1836703946 cites W2016086822 @default.
• W1836703946 cites W2021635600 @default.
• W1836703946 cites W2036987278 @default.
• W1836703946 cites W2037837200 @default.
• W1836703946 cites W2040396943 @default.
• W1836703946 cites W2043781659 @default.
• W1836703946 cites W2048228382 @default.
• W1836703946 cites W2051181798 @default.
• W1836703946 cites W2062166095 @default.
• W1836703946 cites W2069444276 @default.
• W1836703946 cites W2076372887 @default.
• W1836703946 cites W2092408419 @default.
• W1836703946 cites W2096882254 @default.
• W1836703946 cites W2107268345 @default.
• W1836703946 cites W2112817157 @default.
• W1836703946 cites W2115351357 @default.
• W1836703946 cites W2117356576 @default.
• W1836703946 cites W2121743767 @default.
• W1836703946 cites W2122224021 @default.
• W1836703946 cites W2138807703 @default.
• W1836703946 cites W2140102346 @default.
• W1836703946 cites W2144664431 @default.
• W1836703946 cites W2157503763 @default.
• W1836703946 cites W2171358244 @default.
• W1836703946 doi "https://doi.org/10.14800/sp.383" @default.
• W1836703946 hasPublicationYear "2014" @default.
• W1836703946 type Work @default.
• W1836703946 sameAs 1836703946 @default.
• W1836703946 citedByCount "0" @default.
• W1836703946 crossrefType "journal-article" @default.
• W1836703946 hasAuthorship W1836703946A5060367154 @default.
• W1836703946 hasConcept C104317684 @default.
• W1836703946 hasConcept C126322002 @default.
• W1836703946 hasConcept C138626823 @default.
• W1836703946 hasConcept C170493617 @default.
• W1836703946 hasConcept C184235292 @default.
• W1836703946 hasConcept C203014093 @default.
• W1836703946 hasConcept C2777583451 @default.
• W1836703946 hasConcept C2778208673 @default.
• W1836703946 hasConcept C2778729363 @default.
• W1836703946 hasConcept C2778904597 @default.
• W1836703946 hasConcept C2779536868 @default.
• W1836703946 hasConcept C28328180 @default.
• W1836703946 hasConcept C32465701 @default.
• W1836703946 hasConcept C42362537 @default.
• W1836703946 hasConcept C502942594 @default.
• W1836703946 hasConcept C54355233 @default.
• W1836703946 hasConcept C71924100 @default.
• W1836703946 hasConcept C86803240 @default.
• W1836703946 hasConceptScore W1836703946C104317684 @default.
• W1836703946 hasConceptScore W1836703946C126322002 @default.
• W1836703946 hasConceptScore W1836703946C138626823 @default.
• W1836703946 hasConceptScore W1836703946C170493617 @default.
• W1836703946 hasConceptScore W1836703946C184235292 @default.
• W1836703946 hasConceptScore W1836703946C203014093 @default.
• W1836703946 hasConceptScore W1836703946C2777583451 @default.
• W1836703946 hasConceptScore W1836703946C2778208673 @default.
• W1836703946 hasConceptScore W1836703946C2778729363 @default.
• W1836703946 hasConceptScore W1836703946C2778904597 @default.
• W1836703946 hasConceptScore W1836703946C2779536868 @default.
• W1836703946 hasConceptScore W1836703946C28328180 @default.
• W1836703946 hasConceptScore W1836703946C32465701 @default.
• W1836703946 hasConceptScore W1836703946C42362537 @default.
• W1836703946 hasConceptScore W1836703946C502942594 @default.
• W1836703946 hasConceptScore W1836703946C54355233 @default.
• W1836703946 hasConceptScore W1836703946C71924100 @default.
• W1836703946 hasConceptScore W1836703946C86803240 @default.
• W1836703946 hasLocation W18367039461 @default.
• W1836703946 hasOpenAccess W1836703946 @default.
• W1836703946 hasPrimaryLocation W18367039461 @default.
• W1836703946 hasRelatedWork W1489465352 @default.
• W1836703946 hasRelatedWork W1967294088 @default.
• W1836703946 hasRelatedWork W2048637860 @default.
• W1836703946 hasRelatedWork W2133670229 @default.
• W1836703946 hasRelatedWork W2281878130 @default.
• W1836703946 hasRelatedWork W2379831204 @default.
• W1836703946 hasRelatedWork W2559819088 @default.
• W1836703946 hasRelatedWork W2761675969 @default.
• W1836703946 hasRelatedWork W2791220784 @default.
• W1836703946 hasRelatedWork W2920458604 @default.
• W1836703946 hasRelatedWork W2921491167 @default.
• W1836703946 hasRelatedWork W2945758629 @default.
• W1836703946 hasRelatedWork W2969220700 @default.
• W1836703946 hasRelatedWork W3022911983 @default.
• W1836703946 hasRelatedWork W3030730966 @default.
• W1836703946 hasRelatedWork W3030807518 @default.
• W1836703946 hasRelatedWork W3117188854 @default.
• W1836703946 hasRelatedWork W3150954884 @default.
• W1836703946 hasRelatedWork W3204122798 @default.

• next