FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1836708511> ?p ?o ?g. }

• W1836708511 endingPage "6087" @default.
• W1836708511 startingPage "6080" @default.
• W1836708511 abstract "Abstract We have recently identified a peptide derived from the secreted portion of the HSV-2 glycoprotein G, gG-2p20, to be proinflammatory. Based on its ability to activate neutrophils and monocytes via the formyl peptide receptor (FPR) to produce reactive oxygen species (ROS) that down-regulate NK cell function, we suggested it to be of importance in HSV-2 pathogenesis. We now describe the effects of an overlapping peptide, gG-2p19, derived from the same HSV-2 protein. Also, this peptide activated the ROS-generating NADPH-oxidase, however, only in monocytes and not in neutrophils. Surprisingly, gG-2p19 did not induce a chemotactic response in the affected monocytes despite using a pertussis toxin-sensitive, supposedly G-protein-coupled receptor. The specificity for monocytes suggested that FPR and its homologue FPR like-1 (FPRL1) did not function as receptors for gG-2p19, and this was also experimentally confirmed. Surprisingly, the monocyte-specific FPR homologue FPRL2 was not involved either, and the responsible receptor thus remains unknown so far. However, the receptor shares some basic signaling properties with FPRL1 in that the gG-2p19-induced response was inhibited by PBP10, a peptide that has earlier been shown to selectively inhibit FPRL1-triggered responses. We conclude that secretion and subsequent degradation of the HSV-2 glycoprotein G can generate several peptides that activate phagocytes through different receptors, and with different cellular specificities, to generate ROS with immunomodulatory properties." @default.
• W1836708511 created "2016-06-24" @default.
• W1836708511 creator A5003406476 @default.
• W1836708511 creator A5024403082 @default.
• W1836708511 creator A5038963650 @default.
• W1836708511 creator A5039881758 @default.
• W1836708511 creator A5046390385 @default.
• W1836708511 creator A5059745363 @default.
• W1836708511 creator A5067503302 @default.
• W1836708511 date "2007-11-01" @default.
• W1836708511 modified "2023-09-24" @default.
• W1836708511 title "A Monocyte-Specific Peptide from Herpes Simplex Virus Type 2 Glycoprotein G Activates the NADPH-Oxidase but Not Chemotaxis through a G-Protein-Coupled Receptor Distinct from the Members of the Formyl Peptide Receptor Family" @default.
• W1836708511 cites W1482271921 @default.
• W1836708511 cites W1487913306 @default.
• W1836708511 cites W1516021644 @default.
• W1836708511 cites W1518667458 @default.
• W1836708511 cites W1519337174 @default.
• W1836708511 cites W1519897323 @default.
• W1836708511 cites W1558468202 @default.
• W1836708511 cites W1573106415 @default.
• W1836708511 cites W1573635219 @default.
• W1836708511 cites W1576411973 @default.
• W1836708511 cites W1580207422 @default.
• W1836708511 cites W1910332340 @default.
• W1836708511 cites W1968063902 @default.
• W1836708511 cites W1970426618 @default.
• W1836708511 cites W2007634908 @default.
• W1836708511 cites W2008243630 @default.
• W1836708511 cites W2029023072 @default.
• W1836708511 cites W2034486057 @default.
• W1836708511 cites W2034561500 @default.
• W1836708511 cites W2036359942 @default.
• W1836708511 cites W2045608528 @default.
• W1836708511 cites W2049593316 @default.
• W1836708511 cites W2049662845 @default.
• W1836708511 cites W2053202566 @default.
• W1836708511 cites W2062050180 @default.
• W1836708511 cites W2077485715 @default.
• W1836708511 cites W2079168625 @default.
• W1836708511 cites W2084906837 @default.
• W1836708511 cites W2095799155 @default.
• W1836708511 cites W2101291779 @default.
• W1836708511 cites W2101471093 @default.
• W1836708511 cites W2101822881 @default.
• W1836708511 cites W2112545983 @default.
• W1836708511 cites W2137445290 @default.
• W1836708511 cites W2149356582 @default.
• W1836708511 cites W2162885959 @default.
• W1836708511 cites W2319146475 @default.
• W1836708511 cites W2339651847 @default.
• W1836708511 cites W4234329713 @default.
• W1836708511 cites W4236210645 @default.
• W1836708511 cites W4253323627 @default.
• W1836708511 doi "https://doi.org/10.4049/jimmunol.179.9.6080" @default.
• W1836708511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17947682" @default.
• W1836708511 hasPublicationYear "2007" @default.
• W1836708511 type Work @default.
• W1836708511 sameAs 1836708511 @default.
• W1836708511 citedByCount "9" @default.
• W1836708511 countsByYear W18367085112012 @default.
• W1836708511 countsByYear W18367085112013 @default.
• W1836708511 countsByYear W18367085112014 @default.
• W1836708511 countsByYear W18367085112016 @default.
• W1836708511 countsByYear W18367085112017 @default.
• W1836708511 countsByYear W18367085112019 @default.
• W1836708511 crossrefType "journal-article" @default.
• W1836708511 hasAuthorship W1836708511A5003406476 @default.
• W1836708511 hasAuthorship W1836708511A5024403082 @default.
• W1836708511 hasAuthorship W1836708511A5038963650 @default.
• W1836708511 hasAuthorship W1836708511A5039881758 @default.
• W1836708511 hasAuthorship W1836708511A5046390385 @default.
• W1836708511 hasAuthorship W1836708511A5059745363 @default.
• W1836708511 hasAuthorship W1836708511A5067503302 @default.
• W1836708511 hasBestOaLocation W18367085111 @default.
• W1836708511 hasConcept C108625454 @default.
• W1836708511 hasConcept C160448771 @default.
• W1836708511 hasConcept C170493617 @default.
• W1836708511 hasConcept C203014093 @default.
• W1836708511 hasConcept C2776731609 @default.
• W1836708511 hasConcept C2777700362 @default.
• W1836708511 hasConcept C2779281246 @default.
• W1836708511 hasConcept C2779719074 @default.
• W1836708511 hasConcept C2780656570 @default.
• W1836708511 hasConcept C2781184567 @default.
• W1836708511 hasConcept C48349386 @default.
• W1836708511 hasConcept C49773422 @default.
• W1836708511 hasConcept C54166955 @default.
• W1836708511 hasConcept C55493867 @default.
• W1836708511 hasConcept C80631254 @default.
• W1836708511 hasConcept C86803240 @default.
• W1836708511 hasConcept C95444343 @default.
• W1836708511 hasConceptScore W1836708511C108625454 @default.
• W1836708511 hasConceptScore W1836708511C160448771 @default.
• W1836708511 hasConceptScore W1836708511C170493617 @default.
• W1836708511 hasConceptScore W1836708511C203014093 @default.
• W1836708511 hasConceptScore W1836708511C2776731609 @default.
• W1836708511 hasConceptScore W1836708511C2777700362 @default.
• W1836708511 hasConceptScore W1836708511C2779281246 @default.

• next