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- W1836763968 abstract "Conventional therapies for diseases that are associated with protein aggregation typically prevent rather than clear protein aggregates. We have proposed neutron dynamic therapy (NDT) as a physical clearance therapy for protein aggregates. Advanced glycation end-products (AGEs), which are aggregated proteins, have been implicated in diabetes, Alzheimer's, and heart disease. Herein, we report the use of the boron tracedrug UTX-51, under thermal neutron irradiation, as an NDT for the targeted clearance of glycated bovine serum albumin (Gly-BSA), a model of AGEs.Sodium dodecyl sulfate-polyacrylamide gel electrophoresis was performed to detect Gly-BSA decomposition by thermal neutron irradiation treated with UTX-51.The combination of UTX-51 with neutron irradiation showed a decrease in band intensity of Gly-BSA.We present our NDT strategy, which has been used for the targeted clearance of Gly-BSA, suggesting that NDT with boron tracedrugs can be used for the treatment of AGEs-related disease." @default.
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- W1836763968 date "2014-08-01" @default.
- W1836763968 modified "2023-10-16" @default.
- W1836763968 title "An NDT study of a boron tracedrug UTX-51 for glycated BSA as an AGE model." @default.
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