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- W1837137701 abstract "Purpose Adverse drug events (ADEs) are common health problems worldwide. Developing a prediction rule to identify patients at high risk for ADEs to prevent or ameliorate ADEs could be one attractive strategy. Methods The Japan Adverse Drug Events (JADE) study is a prospective cohort study including 3459 participants. We randomly divided the JADE study cohort into the derivation and the validation sets, using an automated random digit generator. We calculated the probabilities of ADE in each patient in the validation set after applying the prediction rule developed in the derivation set. The actual incidence and area under the receiver operating characteristic curve (AUC) in the validation set were compared with those in the derivation set to evaluate the prognostic ability of our developed prediction rule. Results The developed prediction rule included eight independent risk factors. Each patient in the validation set was classified into three categories of risk for the ADEs according to the probability of ADEs calculated by the developed prediction rule. Eight percent (137/1730) of patients in the validation set fell into the high-risk group, and 35% of this group (48/137) had at least one ADE. The AUC in the validation set was 0.63 (95%CI 0.60–0.66), and the performance to discriminate the probability of ADE was similar (p = 0.08) compared with that in the derivation set. Conclusions This prediction rule had the modest predictive ability and could help physicians and other healthcare professionals to make an estimation of patients at high risk for ADEs. Copyright © 2012 John Wiley & Sons, Ltd." @default.
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- W1837137701 date "2012-08-06" @default.
- W1837137701 modified "2023-10-16" @default.
- W1837137701 title "Clinical prediction rule to identify high-risk inpatients for adverse drug events: the JADE Study" @default.
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- W1837137701 doi "https://doi.org/10.1002/pds.3331" @default.
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