Matches in SemOpenAlex for { <https://semopenalex.org/work/W1837274953> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1837274953 endingPage "113" @default.
- W1837274953 startingPage "97" @default.
- W1837274953 abstract "Functional coupling of residues that are far apart in space is the quintessential property of allosteric receptors. Data from functional studies of allosteric receptors, such as whole-cell dose–response relations, can be used to determine if mutation to a receptor significantly impacts agonist potency. However, the classification of perturbations as primarily impacting binding or allosteric function is more challenging, often requiring detailed kinetic studies. This protocol describes a simple strategy, derived from mutant cycle analysis, for elucidating long-range functional coupling in allosteric receptors (ELFCAR). Introduction of a gain-of-function reporter mutation, followed by a mutant cycle analysis of the readily measured macroscopic EC50 values can provide insight into the role of many physically distant targets. This new method should find broad application in determining the functional roles of residues in allosteric receptors." @default.
- W1837274953 created "2016-06-24" @default.
- W1837274953 creator A5002660163 @default.
- W1837274953 creator A5024286952 @default.
- W1837274953 creator A5036420758 @default.
- W1837274953 creator A5047742974 @default.
- W1837274953 date "2011-09-18" @default.
- W1837274953 modified "2023-10-14" @default.
- W1837274953 title "Using Mutant Cycle Analysis to Elucidate Long-Range Functional Coupling in Allosteric Receptors" @default.
- W1837274953 cites W1591881216 @default.
- W1837274953 cites W1632324362 @default.
- W1837274953 cites W1971422019 @default.
- W1837274953 cites W1974988689 @default.
- W1837274953 cites W1981857440 @default.
- W1837274953 cites W1992799801 @default.
- W1837274953 cites W2005242686 @default.
- W1837274953 cites W2007475186 @default.
- W1837274953 cites W2020182741 @default.
- W1837274953 cites W2039840333 @default.
- W1837274953 cites W2067807371 @default.
- W1837274953 cites W2074890710 @default.
- W1837274953 cites W2086166520 @default.
- W1837274953 cites W2086257387 @default.
- W1837274953 cites W2091060891 @default.
- W1837274953 cites W2091485628 @default.
- W1837274953 cites W2094426376 @default.
- W1837274953 cites W2101887667 @default.
- W1837274953 cites W2124676068 @default.
- W1837274953 cites W2129815266 @default.
- W1837274953 cites W2148598721 @default.
- W1837274953 cites W2155280618 @default.
- W1837274953 doi "https://doi.org/10.1007/978-1-61779-334-9_6" @default.
- W1837274953 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4006985" @default.
- W1837274953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22052487" @default.
- W1837274953 hasPublicationYear "2011" @default.
- W1837274953 type Work @default.
- W1837274953 sameAs 1837274953 @default.
- W1837274953 citedByCount "3" @default.
- W1837274953 countsByYear W18372749532012 @default.
- W1837274953 countsByYear W18372749532014 @default.
- W1837274953 countsByYear W18372749532018 @default.
- W1837274953 crossrefType "book-chapter" @default.
- W1837274953 hasAuthorship W1837274953A5002660163 @default.
- W1837274953 hasAuthorship W1837274953A5024286952 @default.
- W1837274953 hasAuthorship W1837274953A5036420758 @default.
- W1837274953 hasAuthorship W1837274953A5047742974 @default.
- W1837274953 hasBestOaLocation W18372749532 @default.
- W1837274953 hasConcept C104317684 @default.
- W1837274953 hasConcept C109964505 @default.
- W1837274953 hasConcept C14036430 @default.
- W1837274953 hasConcept C143065580 @default.
- W1837274953 hasConcept C166342909 @default.
- W1837274953 hasConcept C170493617 @default.
- W1837274953 hasConcept C185592680 @default.
- W1837274953 hasConcept C2776038425 @default.
- W1837274953 hasConcept C2778938600 @default.
- W1837274953 hasConcept C55493867 @default.
- W1837274953 hasConcept C70721500 @default.
- W1837274953 hasConcept C86803240 @default.
- W1837274953 hasConcept C95444343 @default.
- W1837274953 hasConceptScore W1837274953C104317684 @default.
- W1837274953 hasConceptScore W1837274953C109964505 @default.
- W1837274953 hasConceptScore W1837274953C14036430 @default.
- W1837274953 hasConceptScore W1837274953C143065580 @default.
- W1837274953 hasConceptScore W1837274953C166342909 @default.
- W1837274953 hasConceptScore W1837274953C170493617 @default.
- W1837274953 hasConceptScore W1837274953C185592680 @default.
- W1837274953 hasConceptScore W1837274953C2776038425 @default.
- W1837274953 hasConceptScore W1837274953C2778938600 @default.
- W1837274953 hasConceptScore W1837274953C55493867 @default.
- W1837274953 hasConceptScore W1837274953C70721500 @default.
- W1837274953 hasConceptScore W1837274953C86803240 @default.
- W1837274953 hasConceptScore W1837274953C95444343 @default.
- W1837274953 hasLocation W18372749531 @default.
- W1837274953 hasLocation W18372749532 @default.
- W1837274953 hasLocation W18372749533 @default.
- W1837274953 hasLocation W18372749534 @default.
- W1837274953 hasLocation W18372749535 @default.
- W1837274953 hasOpenAccess W1837274953 @default.
- W1837274953 hasPrimaryLocation W18372749531 @default.
- W1837274953 hasRelatedWork W1994399278 @default.
- W1837274953 hasRelatedWork W2000749144 @default.
- W1837274953 hasRelatedWork W2022777395 @default.
- W1837274953 hasRelatedWork W2272684044 @default.
- W1837274953 hasRelatedWork W2617986317 @default.
- W1837274953 hasRelatedWork W2801613715 @default.
- W1837274953 hasRelatedWork W2801942411 @default.
- W1837274953 hasRelatedWork W3197724882 @default.
- W1837274953 hasRelatedWork W4210809282 @default.
- W1837274953 hasRelatedWork W4225089685 @default.
- W1837274953 isParatext "false" @default.
- W1837274953 isRetracted "false" @default.
- W1837274953 magId "1837274953" @default.
- W1837274953 workType "book-chapter" @default.