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• W1837294723 abstract "During a T cell-dependent immune response, B cells undergo clonal expansion and selection and the induction of isotype switching and somatic hypermutation (SHM). Although somatically mutated IgM(+) memory B cells have been reported, it has not been established whether they are really high affinity B cells. We tracked (4-hydroxy-3-nitrophenyl) acetyl hapten-specific GC B cells from normal immunized mice based on affinity of their B cell receptor (BCR) and performed BCR sequence analysis. SHM was evident by day 7 postimmunization and increased with time, such that high affinity IgM(+) as well as IgG(+) memory B cells continued to be generated up to day 42. In contrast, class-switch recombination (CSR) was almost completed by day 7 and then the ratio of IgG1(+)/IgM(+) GC B cells remained unchanged. Together these findings suggest that IgM(+) B cells undergo SHM in the GC to generate high affinity IgM(+) memory cells and that this process continues even after CSR is accomplished." @default.
• W1837294723 created "2016-06-24" @default.
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• W1837294723 date "2015-12-01" @default.
• W1837294723 modified "2023-09-27" @default.
• W1837294723 title "High affinity IgM+ memory B cells are generated through a germinal center-dependent pathway" @default.
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• W1837294723 doi "https://doi.org/10.1016/j.molimm.2015.10.003" @default.
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