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• W1837333360 abstract "To evaluate how the activity of a well-established neurotransmitter pathway is modulated by a behavioral state, 3H-spiperone binding sites and dopamine (DA) and DA metabolite concentrations were measured in the striata of ground squirrels in 5 phases of the hibernation cycle. Whereas levels of striatal DA and its deaminated metabolite DOPAC did not change significantly, the concentrations of the O-methylated- deaminated metabolite, homovanillic acid (HVA), decreased in all phases of hibernation relative to euthermia. Striatal 3H-spiperone binding sites declined across the hibernation cycle in parallel with the reduction of HVA concentration; receptor binding affinity was unchanged by arousal state. In conjunction with previously reported findings, these results are consistent with the hypothesis that hibernation is associated with a down-regulation of the postsynaptic D2 receptors secondary to increased extracellular DA concentration and reduced DA degradation." @default.
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• W1837333360 date "1987-09-01" @default.
• W1837333360 modified "2023-10-10" @default.
• W1837333360 title "Modulation of activity of the striatal dopaminergic system during the hibernation cycle" @default.
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• W1837333360 doi "https://doi.org/10.1523/jneurosci.07-09-02732.1987" @default.
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