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- W1837435921 abstract "This chapter describes results of studies that analyze antibiotic drugs. An R factor that confers resistance to chloramphenicol by decreasing the permeability of the cell membrane to the drug was isolated from Escherichia coli strains of clinical origin. Instances of presumed interbacterial transfer of R factors in mammlian hosts were reported. Requinomycin, a new antibiotic that prevents the transfer of R factors between E. coli strains was described. The structure and biological activity of Sch. 14342, a previously uncharacterized component of the gentamicin fermentation, was reported. This antibiotic, now designated gentamicin B, has an antibacterial spectrum similar to that of gentamicin, but has only about one-third its activity and acute toxicity. However, it is claimed to possess relatively low chronic oto- and nephrotoxicity. The biological properties of several other new naturally occurring pentose-containing aminoglycosides were reported. Clinical trials showed that spectinomycin hydrochloride administered as a single 2- or 4-g dose to men or as a single or double treatment at these doses to women produces cure rates in gonorrhea that regularly exceed 90%. The stereochemistry and absolute configuration of the antibiotic was established by X-ray diffraction studies." @default.
- W1837435921 created "2016-06-24" @default.
- W1837435921 creator A5032031110 @default.
- W1837435921 creator A5061762867 @default.
- W1837435921 date "1973-01-01" @default.
- W1837435921 modified "2023-09-25" @default.
- W1837435921 title "Chapter 12. Antibiotics" @default.
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- W1837435921 doi "https://doi.org/10.1016/s0065-7743(08)61240-3" @default.
- W1837435921 hasPublicationYear "1973" @default.
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