FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1837446566> ?p ?o ?g. }

• W1837446566 endingPage "8062" @default.
• W1837446566 startingPage "8056" @default.
• W1837446566 abstract "Abstract IL-6 is a biological marker of ventilator-associated lung injury that may contribute to alveolar barrier dysfunction in acute respiratory distress syndrome. To determine whether IL-6 affects alveolar barrier disruption in a model of ventilator-induced lung injury, we examined alveolar barrier albumin flux in wild-type (WT) mice given an IL-6-blocking Ab (IL6AB) and mice deficient in IL-6 (IL6KO). Albumin flux was significantly higher in mice given IL6AB compared with mice given a control Ab. Unexpectedly, albumin flux was similar in WT and IL6KO mice. To examine the mechanisms for these findings, lung neutrophil accumulation (myeloperoxidase activity) was compared, revealing a correlation between lung neutrophil accumulation and albumin flux. IL6AB mice had significantly more lung neutrophils than WT and IL6KO mice, which were similar. Therefore, to determine whether the cellular source of IL-6 influences neutrophil accumulation and alveolar barrier function, chimeric mice were compared. WT/KO chimeras (WT mice with IL6KO hematopoietic cells) showed significantly greater albumin flux and neutrophil accumulation with mechanical ventilation than WT/WT mice. Neutrophil depletion decreased albumin flux in WT and WT/KO mice. IL6KO neutrophils were more adherent in an in vitro assay compared with WT neutrophils. IL-6 from a hematopoietic cell source limits alveolar barrier disruption potentially by reducing neutrophil contact with the endothelium. Modulation of IL-6 signaling in a cell type-specific fashion may be a therapeutic target for patients with acute lung injury." @default.
• W1837446566 created "2016-06-24" @default.
• W1837446566 creator A5010417603 @default.
• W1837446566 creator A5019658179 @default.
• W1837446566 creator A5035567835 @default.
• W1837446566 creator A5061976708 @default.
• W1837446566 creator A5068088429 @default.
• W1837446566 creator A5079501705 @default.
• W1837446566 creator A5084809687 @default.
• W1837446566 date "2009-06-15" @default.
• W1837446566 modified "2023-10-15" @default.
• W1837446566 title "Neutrophil-Derived IL-6 Limits Alveolar Barrier Disruption in Experimental Ventilator-Induced Lung Injury" @default.
• W1837446566 cites W1569271652 @default.
• W1837446566 cites W1619504776 @default.
• W1837446566 cites W1880833927 @default.
• W1837446566 cites W1987150557 @default.
• W1837446566 cites W1991940875 @default.
• W1837446566 cites W1994885986 @default.
• W1837446566 cites W2049179991 @default.
• W1837446566 cites W2067761476 @default.
• W1837446566 cites W2077726738 @default.
• W1837446566 cites W2093440835 @default.
• W1837446566 cites W2101962746 @default.
• W1837446566 cites W2119483908 @default.
• W1837446566 cites W2128673878 @default.
• W1837446566 cites W2138343036 @default.
• W1837446566 cites W2156098713 @default.
• W1837446566 cites W2157475929 @default.
• W1837446566 cites W2159352220 @default.
• W1837446566 cites W2160041500 @default.
• W1837446566 cites W2163053457 @default.
• W1837446566 cites W2597070792 @default.
• W1837446566 cites W4236162659 @default.
• W1837446566 cites W4294658238 @default.
• W1837446566 doi "https://doi.org/10.4049/jimmunol.0801323" @default.
• W1837446566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2737530" @default.
• W1837446566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19494331" @default.
• W1837446566 hasPublicationYear "2009" @default.
• W1837446566 type Work @default.
• W1837446566 sameAs 1837446566 @default.
• W1837446566 citedByCount "49" @default.
• W1837446566 countsByYear W18374465662012 @default.
• W1837446566 countsByYear W18374465662013 @default.
• W1837446566 countsByYear W18374465662014 @default.
• W1837446566 countsByYear W18374465662015 @default.
• W1837446566 countsByYear W18374465662016 @default.
• W1837446566 countsByYear W18374465662017 @default.
• W1837446566 countsByYear W18374465662018 @default.
• W1837446566 countsByYear W18374465662019 @default.
• W1837446566 countsByYear W18374465662021 @default.
• W1837446566 countsByYear W18374465662022 @default.
• W1837446566 countsByYear W18374465662023 @default.
• W1837446566 crossrefType "journal-article" @default.
• W1837446566 hasAuthorship W1837446566A5010417603 @default.
• W1837446566 hasAuthorship W1837446566A5019658179 @default.
• W1837446566 hasAuthorship W1837446566A5035567835 @default.
• W1837446566 hasAuthorship W1837446566A5061976708 @default.
• W1837446566 hasAuthorship W1837446566A5068088429 @default.
• W1837446566 hasAuthorship W1837446566A5079501705 @default.
• W1837446566 hasAuthorship W1837446566A5084809687 @default.
• W1837446566 hasBestOaLocation W18374465661 @default.
• W1837446566 hasConcept C126322002 @default.
• W1837446566 hasConcept C185592680 @default.
• W1837446566 hasConcept C203014093 @default.
• W1837446566 hasConcept C203565725 @default.
• W1837446566 hasConcept C2776125364 @default.
• W1837446566 hasConcept C2776914184 @default.
• W1837446566 hasConcept C2777714996 @default.
• W1837446566 hasConcept C51911345 @default.
• W1837446566 hasConcept C55493867 @default.
• W1837446566 hasConcept C71924100 @default.
• W1837446566 hasConcept C86803240 @default.
• W1837446566 hasConcept C95444343 @default.
• W1837446566 hasConceptScore W1837446566C126322002 @default.
• W1837446566 hasConceptScore W1837446566C185592680 @default.
• W1837446566 hasConceptScore W1837446566C203014093 @default.
• W1837446566 hasConceptScore W1837446566C203565725 @default.
• W1837446566 hasConceptScore W1837446566C2776125364 @default.
• W1837446566 hasConceptScore W1837446566C2776914184 @default.
• W1837446566 hasConceptScore W1837446566C2777714996 @default.
• W1837446566 hasConceptScore W1837446566C51911345 @default.
• W1837446566 hasConceptScore W1837446566C55493867 @default.
• W1837446566 hasConceptScore W1837446566C71924100 @default.
• W1837446566 hasConceptScore W1837446566C86803240 @default.
• W1837446566 hasConceptScore W1837446566C95444343 @default.
• W1837446566 hasIssue "12" @default.
• W1837446566 hasLocation W18374465661 @default.
• W1837446566 hasLocation W18374465662 @default.
• W1837446566 hasLocation W18374465663 @default.
• W1837446566 hasLocation W18374465664 @default.
• W1837446566 hasOpenAccess W1837446566 @default.
• W1837446566 hasPrimaryLocation W18374465661 @default.
• W1837446566 hasRelatedWork W1975505913 @default.
• W1837446566 hasRelatedWork W1986176507 @default.
• W1837446566 hasRelatedWork W1989623957 @default.
• W1837446566 hasRelatedWork W2024663116 @default.
• W1837446566 hasRelatedWork W2049605100 @default.
• W1837446566 hasRelatedWork W2059308499 @default.

• next