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• W1837450856 abstract "Variations in porin proteins are common in Gram-negative pathogens. Altered or absent porins reduce access of polar antibiotics across the outer membrane and can thus contribute to antibiotic resistance. Reduced permeability has a cost however, in lowering access to nutrients. This trade-off between permeability and nutritional competence is the source of considerable natural variation in porin gate-keeping. Mutational changes in this trade-off are frequently selected, so susceptibility to detergents and antibiotics is polymorphic in environmental isolates as well as pathogens. Understanding the mechanism, costs and heterogeneity of antibiotic exclusion by porins will be crucial in combating Gram negative infections." @default.
• W1837450856 created "2016-06-24" @default.
• W1837450856 creator A5017774001 @default.
• W1837450856 creator A5069174363 @default.
• W1837450856 date "2015-10-21" @default.
• W1837450856 modified "2023-10-18" @default.
• W1837450856 title "How Porin Heterogeneity and Trade-Offs Affect the Antibiotic Susceptibility of Gram-Negative Bacteria" @default.
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• W1837450856 doi "https://doi.org/10.3390/genes6041113" @default.
• W1837450856 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4690030" @default.
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