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- W1837461025 abstract "Introduction: The serotonin pathway was initially identified as a major player in the pathogenesis of a subset of anorexigen-induced pulmonary arterial hypertension (PAH). It has subsequently been shown to be involved in other forms of PAH. Areas covered: In preclinical experiments, terguride (an anatagonist of type 2 serotonin receptors) was found to reduce proliferation of smooth muscle cells and accumulation of collagen, and decrease pulmonary arterial pressure. Expert opinion: Most therapies currently available for PAH primarily tackle vasoconstriction and endothelial dysfunction, whereas vascular remodeling, which is an early pathogenic event in PAH development, is secondary. If terguride demonstrates a prominent antiremodelling effect in PAH, it could be used as a specific therapy for this rare disease." @default.
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- W1837461025 date "2011-07-16" @default.
- W1837461025 modified "2023-09-27" @default.
- W1837461025 title "Terguride for pulmonary arterial hypertension" @default.
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- W1837461025 doi "https://doi.org/10.1517/14728222.2011.600692" @default.
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