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• W1837506788 abstract "ABSTRACT A key regulator of swarming in Proteus mirabilis is the Rcs phosphorelay, which represses flhDC , encoding the master flagellar regulator FlhD 4 C 2 . Mutants in rcsB , the response regulator in the Rcs phosphorelay, hyperswarm on solid agar and differentiate into swarmer cells in liquid, demonstrating that this system also influences the expression of genes central to differentiation. To gain a further understanding of RcsB-regulated genes involved in swarmer cell differentiation, transcriptome sequencing (RNA-Seq) was used to examine the RcsB regulon. Among the 133 genes identified, minC and minD , encoding cell division inhibitors, were identified as RcsB-activated genes. A third gene, minE , was shown to be part of an operon with minCD . To examine minCDE regulation, the min promoter was identified by 5′ rapid amplification of cDNA ends (5′-RACE), and both transcriptional lacZ fusions and quantitative real-time reverse transcriptase (qRT) PCR were used to confirm that the minCDE operon was RcsB activated. Purified RcsB was capable of directly binding the minC promoter region. To determine the role of RcsB-mediated activation of minCDE in swarmer cell differentiation, a polar minC mutation was constructed. This mutant formed minicells during growth in liquid, produced shortened swarmer cells during differentiation, and exhibited decreased swarming motility. IMPORTANCE This work describes the regulation and role of the MinCDE cell division system in P. mirabilis swarming and swarmer cell elongation. Prior to this study, the mechanisms that inhibit cell division and allow swarmer cell elongation were unknown. In addition, this work outlines for the first time the RcsB regulon in P. mirabilis . Taken together, the data presented in this study begin to address how P. mirabilis elongates upon contact with a solid surface." @default.
• W1837506788 created "2016-06-24" @default.
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• W1837506788 date "2015-08-01" @default.
• W1837506788 modified "2023-10-16" @default.
• W1837506788 title "Regulation of the Min Cell Division Inhibition Complex by the Rcs Phosphorelay in Proteus mirabilis" @default.
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• W1837506788 doi "https://doi.org/10.1128/jb.00094-15" @default.
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