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• W1837509507 startingPage "149" @default.
• W1837509507 abstract "In recent times, there has been an increase in the knowledge of the mechanisms of action of chemotherapeutic agents so that, in some cases, it is now possible to identify a specific enzyme or cell component as the primary site of a drug's action. Perhaps, one of the most striking and unexpected findings to come from the studies on the mechanism of drug action is that a number of antibiotics and synthetic drugs do not act by inhibiting a reaction or combining with a cell component that is unique to a particular micro-organism, but block such universal processes as the synthesis of proteins or nucleic acids. In case of some drugs that inhibit the replication of DNA or interfere with its function, there is now strong evidence that they achieve their effect by combining with DNA itself, rather than with sites on DNA-dependent polymerases or by blocking the synthesis of nucleic acid precursors. It is with some of these compounds that the present review is concerned. In recent years, there have been many reports on the interaction of drugs and antibiotics, most of which is unknown structure, with nucleic acids. It must be emphasized at the outset that the author has made no attempt to produce a comprehensive review of such studies. The discussion in this chapter has been limited to compounds whose structure has been unequivocally established and whose interaction with DNA has been critically studied. The compounds discussed have also been selected to illustrate the different types of binding to DNA. Identification of DNA as the primary binding site of a chemotherapeutic agent and the discovery that the drug selectively interferes with the synthesis or function of this nucleic acid in vivo does not mean that the investigation of drug action has achieved its goal." @default.
• W1837509507 created "2016-06-24" @default.
• W1837509507 creator A5036768818 @default.
• W1837509507 date "1971-01-01" @default.
• W1837509507 modified "2023-09-26" @default.
• W1837509507 title "Chemotherapeutic Compounds Affecting DNA Structure and Function" @default.
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