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• W1837528440 startingPage "559" @default.
• W1837528440 abstract "Recovery of urinary tract function after spinal cord injury (SCI) is important in its own right and may also serve as a model for studying mechanisms of functional recovery after injury in the CNS. Normal micturition requires coordinated activation of smooth muscle of the bladder (detrusor) and striated muscle of the external urethral sphincter (EUS) that is controlled by spinal and supraspinal circuitry. We used a clinically relevant rat model of thoracic spinal cord contusion injury to examine the effect of varying the degree of residual supraspinal connections on chronic detrusor–EUS coordination. Urodynamic evaluation at 8 weeks after SCI showed that detrusor contractions of the bladder recovered similarly in groups of rats injured with a 10 gm weight dropped 12.5, 25, or 50 mm onto the spinal cord. In contrast, the degree of coordinated activation of the EUS varied with the severity of initial injury and the degree of preservation of white matter at the injury site. The 12.5 mm SCI resulted in the sparing of 20% of the white matter at the injury site and complete recovery of detrusor–EUS coordination. In more severely injured rats, the chronic recovery of detrusor–EUS coordination was very incomplete and correlated to decreased innervation of lower motoneurons by descending control pathways and their increased levels of mRNA for glutamate receptor subunits NR2A and GluR2. These results show that the extent of recovery of detrusor–EUS coordination depends on injury severity and the degree of residual connections with brainstem control centers." @default.
• W1837528440 created "2016-06-24" @default.
• W1837528440 creator A5051753703 @default.
• W1837528440 creator A5073753234 @default.
• W1837528440 date "2001-01-15" @default.
• W1837528440 modified "2023-09-27" @default.
• W1837528440 title "Coordination of the Bladder Detrusor and the External Urethral Sphincter in a Rat Model of Spinal Cord Injury: Effect of Injury Severity" @default.
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• W1837528440 doi "https://doi.org/10.1523/jneurosci.21-02-00559.2001" @default.
• W1837528440 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6763801" @default.
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