FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1837652839> ?p ?o ?g. }

• W1837652839 abstract "Inhaled nitric oxide (iNO) is effective in term infants with hypoxic respiratory failure. The pathophysiology of respiratory failure and the potential risks of iNO differ substantially in preterm infants, necessitating specific study in this population.To determine effects of treatment with inhaled nitric oxide (iNO) on death, bronchopulmonary dysplasia (BPD), intraventricular haemorrhage (IVH) or other serious brain injury and on adverse long-term neurodevelopmental outcomes in preterm newborn infants with hypoxic respiratory failure.Owing to substantial variation in study eligibility criteria, which decreases the utility of an overall analysis, we divided participants post hoc into three groups: (1) infants treated over the first three days of life because of defects in oxygenation, (2) preterm infants with evidence of pulmonary disease treated routinely with iNO and (3) infants treated later (after three days of age) because of elevated risk of BPD.We used standard methods of the Cochrane Neonatal Review Group. We searched MEDLINE, Embase, Healthstar and the Cochrane Central Register of Controlled Trials in the Cochrane Library through January 2016. We also searched the abstracts of the Pediatric Academic Societies.Eligible for inclusion were randomised and quasi-randomised studies in preterm infants with respiratory disease that compared effects of iNO gas versus control, with or without placebo.We used standard methods of the Cochrane Neonatal Review Group and applied the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to assess the quality of evidence.We found 17 randomised controlled trials of iNO therapy in preterm infants. We grouped these trials post hoc into three categories on the basis of entry criteria: treatment during the first three days of life for impaired oxygenation, routine use in preterm babies along with respiratory support and later treatment for infants at increased risk for bronchopulmonary dysplasia (BPD). We performed no overall analyses.Eight trials providing early rescue treatment for infants on the basis of oxygenation criteria demonstrated no significant effect of iNO on mortality or BPD (typical risk ratio (RR) 0.94, 95% confidence interval (CI) 0.87 to 1.01; 958 infants). Four studies examining routine use of iNO in infants with pulmonary disease reported no significant reduction in death or BPD (typical RR 0.94, 95% CI 0.87 to 1.02; 1924 infants), although this small effect approached significance. Later treatment with iNO based on risk of BPD (three trials) revealed no significant benefit for this outcome in analyses of summary data (typical RR 0.92, 95% CI 0.85 to 1.01; 1075 infants).Investigators found no clear effect of iNO on the frequency of all grades of IVH nor severe IVH. Early rescue treatment was associated with a non-significant 20% increase in severe IVH.We found no effect on the incidence of neurodevelopmental impairment.iNO does not appear to be effective as rescue therapy for the very ill preterm infant. Early routine use of iNO in preterm infants with respiratory disease does not prevent serious brain injury or improve survival without BPD. Later use of iNO to prevent BPD could be effective, but current 95% confidence intervals include no effect; the effect size is likely small (RR 0.92) and requires further study." @default.
• W1837652839 created "2016-06-24" @default.
• W1837652839 creator A5007329349 @default.
• W1837652839 creator A5028307208 @default.
• W1837652839 creator A5078821172 @default.
• W1837652839 date "2017-01-03" @default.
• W1837652839 modified "2023-10-16" @default.
• W1837652839 title "Inhaled nitric oxide for respiratory failure in preterm infants" @default.
• W1837652839 cites W115692110 @default.
• W1837652839 cites W1510772032 @default.
• W1837652839 cites W1546018900 @default.
• W1837652839 cites W1555329455 @default.
• W1837652839 cites W1597549428 @default.
• W1837652839 cites W1597605340 @default.
• W1837652839 cites W1597886774 @default.
• W1837652839 cites W1837652839 @default.
• W1837652839 cites W1927797304 @default.
• W1837652839 cites W1968305818 @default.
• W1837652839 cites W1968723218 @default.
• W1837652839 cites W1973885213 @default.
• W1837652839 cites W1985750490 @default.
• W1837652839 cites W1985864082 @default.
• W1837652839 cites W1992134746 @default.
• W1837652839 cites W1997321967 @default.
• W1837652839 cites W2002822787 @default.
• W1837652839 cites W2003276028 @default.
• W1837652839 cites W2004486757 @default.
• W1837652839 cites W2005207475 @default.
• W1837652839 cites W2014032888 @default.
• W1837652839 cites W2023349900 @default.
• W1837652839 cites W2025893376 @default.
• W1837652839 cites W2032786136 @default.
• W1837652839 cites W2034839517 @default.
• W1837652839 cites W2038302852 @default.
• W1837652839 cites W2039420762 @default.
• W1837652839 cites W2040576140 @default.
• W1837652839 cites W2048272805 @default.
• W1837652839 cites W2050699728 @default.
• W1837652839 cites W2052940703 @default.
• W1837652839 cites W2055274506 @default.
• W1837652839 cites W2055289497 @default.
• W1837652839 cites W2055666664 @default.
• W1837652839 cites W2065389442 @default.
• W1837652839 cites W2069323102 @default.
• W1837652839 cites W2072870498 @default.
• W1837652839 cites W2075193323 @default.
• W1837652839 cites W2085402815 @default.
• W1837652839 cites W2088263403 @default.
• W1837652839 cites W2089708574 @default.
• W1837652839 cites W2093216413 @default.
• W1837652839 cites W2099744505 @default.
• W1837652839 cites W2102473536 @default.
• W1837652839 cites W2103266660 @default.
• W1837652839 cites W2103294278 @default.
• W1837652839 cites W2106179385 @default.
• W1837652839 cites W2115552922 @default.
• W1837652839 cites W2118743876 @default.
• W1837652839 cites W2135834409 @default.
• W1837652839 cites W2136881786 @default.
• W1837652839 cites W2143692326 @default.
• W1837652839 cites W2144821608 @default.
• W1837652839 cites W2147875946 @default.
• W1837652839 cites W2159943126 @default.
• W1837652839 cites W2172144141 @default.
• W1837652839 cites W2261463650 @default.
• W1837652839 cites W2273659777 @default.
• W1837652839 cites W2468194126 @default.
• W1837652839 cites W2596898677 @default.
• W1837652839 cites W2969483290 @default.
• W1837652839 cites W4232054669 @default.
• W1837652839 cites W4238695592 @default.
• W1837652839 cites W4248018145 @default.
• W1837652839 cites W4255256525 @default.
• W1837652839 cites W4297949492 @default.
• W1837652839 cites W4361868993 @default.
• W1837652839 doi "https://doi.org/10.1002/14651858.cd000509.pub5" @default.
• W1837652839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6464861" @default.
• W1837652839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28045472" @default.
• W1837652839 hasPublicationYear "2017" @default.
• W1837652839 type Work @default.
• W1837652839 sameAs 1837652839 @default.
• W1837652839 citedByCount "132" @default.
• W1837652839 countsByYear W18376528392012 @default.
• W1837652839 countsByYear W18376528392013 @default.
• W1837652839 countsByYear W18376528392014 @default.
• W1837652839 countsByYear W18376528392015 @default.
• W1837652839 countsByYear W18376528392016 @default.
• W1837652839 countsByYear W18376528392017 @default.
• W1837652839 countsByYear W18376528392018 @default.
• W1837652839 countsByYear W18376528392019 @default.
• W1837652839 countsByYear W18376528392020 @default.
• W1837652839 countsByYear W18376528392021 @default.
• W1837652839 countsByYear W18376528392022 @default.
• W1837652839 countsByYear W18376528392023 @default.
• W1837652839 crossrefType "journal-article" @default.
• W1837652839 hasAuthorship W1837652839A5007329349 @default.
• W1837652839 hasAuthorship W1837652839A5028307208 @default.
• W1837652839 hasAuthorship W1837652839A5078821172 @default.
• W1837652839 hasBestOaLocation W18376528392 @default.
• W1837652839 hasConcept C126322002 @default.

• next