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- W1837666989 abstract "Adults with von Willebrand Disease (VWD) are known to have a ratio of factor VIII activity (FVIII:C) to von Willebrand factor antigen (VWF:Ag) greater than 1. We, however, noted healthy children with ratios that are unexpectedly high. Though the FVIII:C/VWF:Ag ratio differs significantly between healthy children and VWD patients in some age groups, the substantial overlap of observed ranges suggests that a ratio threshold‐based screening approach alone cannot reliably discriminate between these groups. The diagnostic performance of this ratio is poor for VWD in children, which may decrease its value as a screening tool in the pediatric population. Pediatr Blood Cancer 2014;61:936–939. © 2013 Wiley Periodicals, Inc." @default.
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- W1837666989 date "2013-11-26" @default.
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- W1837666989 title "FVIII/VWF ratio is not a reliable predictor of VWD in children" @default.
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- W1837666989 doi "https://doi.org/10.1002/pbc.24860" @default.
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