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- W1837746667 abstract "The physical interactions among cells and extracellular matrix guide the physiological behavior of tissues. The success of reparative medicine and tissue engineering depends on the ability to promote migratory cell behavior for wound healing and vascular development and a quiescent phenotype for tissue and blood vessel stabilization. Thus, an improved understanding of how cells sense mechanochemical cues in their local environment is a critical challenge facing biomedical engineers. Because the cytoskeleton represents an interconnected mechanical structure that dynamically interacts with signaling proteins throughout the cell, it is a primary candidate to act as a central controller to integrate and differentiate complex signaling networks that determine cellular phenotype. This chapter explores mechanisms of physical interaction and signaling from the cytoskeleton to the extracellular matrix, using endothelial responses to hemodynamic forces as an example to suggest that a systems modeling approach will open new directions for vascular bioengineering." @default.
- W1837746667 created "2016-06-24" @default.
- W1837746667 creator A5013069120 @default.
- W1837746667 creator A5057798236 @default.
- W1837746667 date "2006-01-01" @default.
- W1837746667 modified "2023-10-14" @default.
- W1837746667 title "CONTROL OF ENDOTHELIAL CELL ADHESION BY MECHANOTRANSMISSION FROM CYTOSKELETON TO SUBSTRATE" @default.
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- W1837746667 doi "https://doi.org/10.1016/b978-012369392-1/50003-6" @default.
- W1837746667 hasPublicationYear "2006" @default.
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