FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1837807344> ?p ?o ?g. }

• W1837807344 endingPage "1243" @default.
• W1837807344 startingPage "1232" @default.
• W1837807344 abstract "The structures of copper amine oxidases from various sources show good similarity, suggesting similar catalytic mechanisms for all members of this enzyme family. However, the optimal substrates for each member differ, depending on the source of the enzyme and its location. The structural factors underlying substrate selectivity still remain to be discovered. With this in view, we examined the kinetic behaviour of pea seedling amine oxidase with cadaverine and hexylamine, the first bearing two, and the second only one, positively charged amino group. The dependence of K(m) and catalytic constant (k(c)) values on pH, ionic strength and temperature indicates that binding of the monoamine is driven by hydrophobic interactions. Instead, binding of the diamine is strongly facilitated by electrostatic factors, controlled by polar side-chains and two titratable residues present in the active site. The position of the docked substrate is also essential for the participation of titratable amino acid residues in the following catalytic steps. A new mechanistic model explaining the substrate-dependent kinetics of the reaction is discussed." @default.
• W1837807344 created "2016-06-24" @default.
• W1837807344 creator A5013000080 @default.
• W1837807344 creator A5015249037 @default.
• W1837807344 creator A5051035762 @default.
• W1837807344 creator A5060057866 @default.
• W1837807344 creator A5062558275 @default.
• W1837807344 creator A5078144452 @default.
• W1837807344 date "2011-03-01" @default.
• W1837807344 modified "2023-10-09" @default.
• W1837807344 title "Active site residue involvement in monoamine or diamine oxidation catalysed by pea seedling amine oxidase" @default.
• W1837807344 cites W1536418167 @default.
• W1837807344 cites W1569786530 @default.
• W1837807344 cites W1576384803 @default.
• W1837807344 cites W1617531543 @default.
• W1837807344 cites W1911684464 @default.
• W1837807344 cites W1914630957 @default.
• W1837807344 cites W1963518407 @default.
• W1837807344 cites W1965510593 @default.
• W1837807344 cites W1965806915 @default.
• W1837807344 cites W1971240612 @default.
• W1837807344 cites W1971963743 @default.
• W1837807344 cites W1975761125 @default.
• W1837807344 cites W1977856515 @default.
• W1837807344 cites W1979368197 @default.
• W1837807344 cites W1989883347 @default.
• W1837807344 cites W1996824566 @default.
• W1837807344 cites W1999179466 @default.
• W1837807344 cites W2000421888 @default.
• W1837807344 cites W2005489176 @default.
• W1837807344 cites W2005575697 @default.
• W1837807344 cites W2008769585 @default.
• W1837807344 cites W2011656574 @default.
• W1837807344 cites W2016705597 @default.
• W1837807344 cites W2017515303 @default.
• W1837807344 cites W2019179623 @default.
• W1837807344 cites W2045292118 @default.
• W1837807344 cites W2050761816 @default.
• W1837807344 cites W2056951579 @default.
• W1837807344 cites W2064575020 @default.
• W1837807344 cites W2066761542 @default.
• W1837807344 cites W2069350944 @default.
• W1837807344 cites W2074420055 @default.
• W1837807344 cites W2077862143 @default.
• W1837807344 cites W2083700484 @default.
• W1837807344 cites W2084591908 @default.
• W1837807344 cites W2086184767 @default.
• W1837807344 cites W2087347863 @default.
• W1837807344 cites W2096379987 @default.
• W1837807344 cites W2116838198 @default.
• W1837807344 cites W2118780511 @default.
• W1837807344 cites W2146738740 @default.
• W1837807344 cites W2158534713 @default.
• W1837807344 cites W2403297264 @default.
• W1837807344 cites W4251801775 @default.
• W1837807344 doi "https://doi.org/10.1111/j.1742-4658.2011.08044.x" @default.
• W1837807344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21294844" @default.
• W1837807344 hasPublicationYear "2011" @default.
• W1837807344 type Work @default.
• W1837807344 sameAs 1837807344 @default.
• W1837807344 citedByCount "4" @default.
• W1837807344 countsByYear W18378073442014 @default.
• W1837807344 countsByYear W18378073442017 @default.
• W1837807344 countsByYear W18378073442018 @default.
• W1837807344 countsByYear W18378073442021 @default.
• W1837807344 crossrefType "journal-article" @default.
• W1837807344 hasAuthorship W1837807344A5013000080 @default.
• W1837807344 hasAuthorship W1837807344A5015249037 @default.
• W1837807344 hasAuthorship W1837807344A5051035762 @default.
• W1837807344 hasAuthorship W1837807344A5060057866 @default.
• W1837807344 hasAuthorship W1837807344A5062558275 @default.
• W1837807344 hasAuthorship W1837807344A5078144452 @default.
• W1837807344 hasBestOaLocation W18378073441 @default.
• W1837807344 hasConcept C117001961 @default.
• W1837807344 hasConcept C131779359 @default.
• W1837807344 hasConcept C161790260 @default.
• W1837807344 hasConcept C178790620 @default.
• W1837807344 hasConcept C181199279 @default.
• W1837807344 hasConcept C185592680 @default.
• W1837807344 hasConcept C18903297 @default.
• W1837807344 hasConcept C2776024655 @default.
• W1837807344 hasConcept C2777289219 @default.
• W1837807344 hasConcept C2779053737 @default.
• W1837807344 hasConcept C2779183435 @default.
• W1837807344 hasConcept C41183919 @default.
• W1837807344 hasConcept C71240020 @default.
• W1837807344 hasConcept C86803240 @default.
• W1837807344 hasConceptScore W1837807344C117001961 @default.
• W1837807344 hasConceptScore W1837807344C131779359 @default.
• W1837807344 hasConceptScore W1837807344C161790260 @default.
• W1837807344 hasConceptScore W1837807344C178790620 @default.
• W1837807344 hasConceptScore W1837807344C181199279 @default.
• W1837807344 hasConceptScore W1837807344C185592680 @default.
• W1837807344 hasConceptScore W1837807344C18903297 @default.
• W1837807344 hasConceptScore W1837807344C2776024655 @default.
• W1837807344 hasConceptScore W1837807344C2777289219 @default.
• W1837807344 hasConceptScore W1837807344C2779053737 @default.
• W1837807344 hasConceptScore W1837807344C2779183435 @default.

• next