Matches in SemOpenAlex for { <https://semopenalex.org/work/W1837847035> ?p ?o ?g. }
- W1837847035 endingPage "92" @default.
- W1837847035 startingPage "78" @default.
- W1837847035 abstract "Recent promising clinical results of RNA therapeutics have drawn big attention of academia and industries to RNA therapeutics and their carrier systems. To improve their feasibility in clinics, systemic evaluations of currently available carrier systems under clinical trials and preclinical studies are needed. In this review, we focus on recent noticeable preclinical studies and clinical results regarding siRNA-based conjugates for clinical translations. Advantages and drawbacks of siRNA-based conjugates are discussed, compared to particle-based delivery systems. Then, representative siRNA-based conjugates with aptamers, peptides, carbohydrates, lipids, polymers, and nanostructured materials are introduced. To improve feasibility of siRNA conjugates in preclinical studies, several considerations for the rational design of siRNA conjugates in terms of cleavability, immune responses, multivalent conjugations, and mechanism of action are also presented. Lastly, we discuss lessons from previous preclinical and clinical studies related to siRNA conjugates and perspectives of their clinical applications." @default.
- W1837847035 created "2016-06-24" @default.
- W1837847035 creator A5006790800 @default.
- W1837847035 creator A5035646159 @default.
- W1837847035 creator A5077563153 @default.
- W1837847035 creator A5082043212 @default.
- W1837847035 date "2016-09-01" @default.
- W1837847035 modified "2023-09-29" @default.
- W1837847035 title "Current preclinical small interfering RNA (siRNA)-based conjugate systems for RNA therapeutics" @default.
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