FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1838004297> ?p ?o ?g. }

• W1838004297 endingPage "934" @default.
• W1838004297 startingPage "927" @default.
• W1838004297 abstract "Terminalia chebula (TC) is native to southern Asia to southwestern China and is used in traditional medicine for the treatment of human ailments including malignant tumors and diabetes. This plant also has antibacterial and immunomodulatory properties. Nuclear factor kappa-light chain-enhancer of activated B cells (NF-κB) is responsible for the expression of numerous genes involved in cell survival, proliferation, angiogenesis, inflammation, invasion and metastasis, among other processes. This study aims to assess the NF-κB inhibitory effect of TC extract in human lymphoblastic T (Jurkat) cells. The effects of TC extract were investigated using the FRET-based Gene Blazer technique in transfected Jurkat-NF-κB-RE-bla cells. The concentration of TC extract required for NF-κB inhibition was determined by a cell proliferation assay. Treatment with TC extract (50 μg/mL) inhibited NF-κB activity and protected against IκBα degradation and strongly suppressed IκBα phosphorylation in Jurkat-NF-κB-RE-bla cells. This treatment might be crucial for inhibiting NF-κB translocation and activation. In addition, the TC extract downregulated certain NF-κB regulated genes, including IL-8 and MCP-1, in Jurkat-NF-κB-RE-bla cells. Moreover, gallic acid was identified from the TC extract demonstrating its ability to inhibit NF-κB activity in Jurkat-NF-κB-RE-bla cells. Further studies to identify the role of gallic acid in NF-κB inhibition may uncover the crucial antiinflammatory and antitumor properties of the TC extract." @default.
• W1838004297 created "2016-06-24" @default.
• W1838004297 creator A5008244133 @default.
• W1838004297 creator A5018820360 @default.
• W1838004297 creator A5022176695 @default.
• W1838004297 creator A5030180145 @default.
• W1838004297 creator A5032840567 @default.
• W1838004297 creator A5033672171 @default.
• W1838004297 creator A5044914611 @default.
• W1838004297 creator A5049706294 @default.
• W1838004297 creator A5061441823 @default.
• W1838004297 creator A5074753836 @default.
• W1838004297 creator A5083515325 @default.
• W1838004297 creator A5085159256 @default.
• W1838004297 date "2011-04-20" @default.
• W1838004297 modified "2023-10-13" @default.
• W1838004297 title "Terminalia chebula Extract Acts as a Potential NF-κB Inhibitor in Human Lymphoblastic T Cells" @default.
• W1838004297 cites W1548219170 @default.
• W1838004297 cites W1581923494 @default.
• W1838004297 cites W1967838187 @default.
• W1838004297 cites W1969989426 @default.
• W1838004297 cites W1973862406 @default.
• W1838004297 cites W1982504977 @default.
• W1838004297 cites W1983771472 @default.
• W1838004297 cites W1985931135 @default.
• W1838004297 cites W1987938021 @default.
• W1838004297 cites W1990275638 @default.
• W1838004297 cites W1994786322 @default.
• W1838004297 cites W2001385809 @default.
• W1838004297 cites W2011347641 @default.
• W1838004297 cites W2011996641 @default.
• W1838004297 cites W2018011543 @default.
• W1838004297 cites W2019334036 @default.
• W1838004297 cites W2024991882 @default.
• W1838004297 cites W2030205619 @default.
• W1838004297 cites W2043892945 @default.
• W1838004297 cites W2052908553 @default.
• W1838004297 cites W2056533846 @default.
• W1838004297 cites W2063221399 @default.
• W1838004297 cites W2063270450 @default.
• W1838004297 cites W2066570551 @default.
• W1838004297 cites W2072298751 @default.
• W1838004297 cites W2072319732 @default.
• W1838004297 cites W2072692638 @default.
• W1838004297 cites W2073619176 @default.
• W1838004297 cites W2085278061 @default.
• W1838004297 cites W2090850776 @default.
• W1838004297 cites W2093495437 @default.
• W1838004297 cites W2106877484 @default.
• W1838004297 cites W2107077759 @default.
• W1838004297 cites W2108244474 @default.
• W1838004297 cites W2125535914 @default.
• W1838004297 cites W2136227893 @default.
• W1838004297 cites W2138885527 @default.
• W1838004297 cites W2158896327 @default.
• W1838004297 cites W2169150244 @default.
• W1838004297 cites W4238285497 @default.
• W1838004297 doi "https://doi.org/10.1002/ptr.3398" @default.
• W1838004297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21509843" @default.
• W1838004297 hasPublicationYear "2011" @default.
• W1838004297 type Work @default.
• W1838004297 sameAs 1838004297 @default.
• W1838004297 citedByCount "33" @default.
• W1838004297 countsByYear W18380042972012 @default.
• W1838004297 countsByYear W18380042972013 @default.
• W1838004297 countsByYear W18380042972014 @default.
• W1838004297 countsByYear W18380042972015 @default.
• W1838004297 countsByYear W18380042972016 @default.
• W1838004297 countsByYear W18380042972017 @default.
• W1838004297 countsByYear W18380042972018 @default.
• W1838004297 countsByYear W18380042972019 @default.
• W1838004297 countsByYear W18380042972020 @default.
• W1838004297 countsByYear W18380042972022 @default.
• W1838004297 countsByYear W18380042972023 @default.
• W1838004297 crossrefType "journal-article" @default.
• W1838004297 hasAuthorship W1838004297A5008244133 @default.
• W1838004297 hasAuthorship W1838004297A5018820360 @default.
• W1838004297 hasAuthorship W1838004297A5022176695 @default.
• W1838004297 hasAuthorship W1838004297A5030180145 @default.
• W1838004297 hasAuthorship W1838004297A5032840567 @default.
• W1838004297 hasAuthorship W1838004297A5033672171 @default.
• W1838004297 hasAuthorship W1838004297A5044914611 @default.
• W1838004297 hasAuthorship W1838004297A5049706294 @default.
• W1838004297 hasAuthorship W1838004297A5061441823 @default.
• W1838004297 hasAuthorship W1838004297A5074753836 @default.
• W1838004297 hasAuthorship W1838004297A5083515325 @default.
• W1838004297 hasAuthorship W1838004297A5085159256 @default.
• W1838004297 hasConcept C104317684 @default.
• W1838004297 hasConcept C123298856 @default.
• W1838004297 hasConcept C153911025 @default.
• W1838004297 hasConcept C179464577 @default.
• W1838004297 hasConcept C185592680 @default.
• W1838004297 hasConcept C203014093 @default.
• W1838004297 hasConcept C2776090121 @default.
• W1838004297 hasConcept C2777730290 @default.
• W1838004297 hasConcept C2778004101 @default.
• W1838004297 hasConcept C2778362808 @default.
• W1838004297 hasConcept C2779730028 @default.

• next